What kind of a life for a scientific journal?

abstract：:Cell adhesion and migration are complex processes that require integrin activation, the formation and dissolution of focal adhesion (FAs), and linkage of actin cytoskeleton to the FAs. The IPP (ILK, PINCH, Parvin) complex regulates FA formation via binding of the adaptor protein ILK to β1 integrin, PINCH and parvin. T...

journal_title：Journal of cell communication and signaling

authors： Gonzalez-Nieves R,Desantis AI,Cutler ML

更新日期：2013-12-01 00:00:00

abstract：:Mitogen activated protein kinases (MAPKs) play an important role in activation, differentiation and proliferation of macrophages. Macrophages, upon activation, produce large amounts of nitric oxide that inhibit the growth of variety of microorganisms and tumor cells. This nitric oxide which is known to interfere with ...

journal_title：Journal of cell communication and signaling

authors： Narang H,Dhariwala FA,Krishna M

更新日期：2007-12-01 00:00:00

abstract：:Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epi...

journal_title：Journal of cell communication and signaling

authors： Fiaturi N,Russo JW,Nielsen HC,Castellot JJ Jr

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to investigate the effects of homocysteine (Hcy), a risk factor for cardiovascular diseases, hypertension, stroke and obesity, on expression of CD36 that regulates uptake of oxidized low-density lipoprotein (Ox-LDL) by adipocytes and differentiation of 3T3-L1 cells to adipocytes. Cell viabili...

journal_title：Journal of cell communication and signaling

authors： Mentese A,Alver A,Sumer A,Demir S

更新日期：2016-03-01 00:00:00

abstract：:Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyr...

journal_title：Journal of cell communication and signaling

authors： Yelamanchi SD,Jayaram S,Thomas JK,Gundimeda S,Khan AA,Singhal A,Keshava Prasad TS,Pandey A,Somani BL,Gowda H

更新日期：2016-03-01 00:00:00

abstract：:Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic domain. These adjacent domains bind to extracellular matrix proteins (type I collagen, fibronectin, tenascin-C, and laminin γ2), and BM...

journal_title：Journal of cell communication and signaling

authors： Kudo A,Kii I

更新日期：2018-03-01 00:00:00

abstract：:Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are treated using similar chemotherapy regimes. In this review we look at the role of the CCN family of matricellular proteins and indicate their role in nine haematologi...

journal_title：Journal of cell communication and signaling

authors： Wells JE,Howlett M,Cheung LC,Kees UR

更新日期：2015-09-01 00:00:00

abstract：:Erlotinib is an oral tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) pathway. Although our previous study has proved the efficacy of Erlotinib in head and neck squamous cell carcinoma (HNSCC), it has also demonstrated poor clinical response rates and disappointing results in clinical trials for HN...

journal_title：Journal of cell communication and signaling

authors： Zheng Y,Song A,Zhou Y,Zhong Y,Zhang W,Wang C,Ding X,Du Y,Zhang W,Li G,Wu H,Wu Y,Song X

更新日期：2020-12-01 00:00:00

abstract：:The Rsu1 protein contributes to cell adhesion and migration via its association with the adaptor complex of Integrin linked kinase (ILK), PINCH, and Parvin (IPP), which binds to the cytoplasmic domain of β1 integrins joining integrins to the actin cytoskeleton. Rsu1 binding to PINCH in the IPP complex is required for ...

journal_title：Journal of cell communication and signaling

authors： Kim YC,Gonzalez-Nieves R,Cutler ML

更新日期：2019-09-01 00:00:00

abstract：:Extracellular molecules coordinate the multiple signaling pathways spatiotemporally to exchange information between cells during development. Understanding the regulation of these signal molecule-dependent pathways elucidates the mechanism of intercellular crosstalks. CCN2/CTGF is one of the CCN family members that bi...

journal_title：Journal of cell communication and signaling

authors： Ohta K,Aoyama E,Ahmad SAI,Ito N,Anam MB,Kubota S,Takigawa M

更新日期：2019-03-01 00:00:00

abstract：:UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. This family of receptors can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, wher...

journal_title：Journal of cell communication and signaling

authors： Bhat SA,Gurtoo S,Deolankar SC,Fazili KM,Advani J,Shetty R,Prasad TSK,Andrabi S,Subbannayya Y

更新日期：2019-03-01 00:00:00

abstract：:Pancreatitis is an inflammatory condition of the pancreas which, in its chronic form, involves tissue destruction, exocrine and endocrine insufficiency, increased risk of pancreatic cancer, and an extensive fibrotic pathology which is due to unrelenting collagen deposition by pancreatic stellate cells (PSC). In respon...

journal_title：Journal of cell communication and signaling

authors： Charrier A,Chen R,Chen L,Kemper S,Hattori T,Takigawa M,Brigstock DR

更新日期：2014-06-01 00:00:00

abstract：:In breast cancer cells, the linoleic acid (LA), an ω-6 essential polyunsaturated fatty acid, induces a variety of biological processes, including migration and invasion. Extracellular vesicles (EVs) are structures released by normal and malignant cells into extracellular space, and their function is dependent on their...

journal_title：Journal of cell communication and signaling

authors： Leal-Orta E,Ramirez-Ricardo J,Cortes-Reynosa P,Galindo-Hernandez O,Salazar EP

更新日期：2019-06-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF-1) is the first FGF family member, and it induces proliferation of fibroblasts and other types of the cells. However, recent studies are uncovering unexpected functions of this molecule. Our previous study redefined this growth factor as a catabolic molecule produced in cartilage upon m...

journal_title：Journal of cell communication and signaling

authors： Elseoudi A,Nishida T,Mizukawa T,Hattori T,Kawata K,Taha EA,Takigawa M,Kubota S

更新日期：2021-01-04 00:00:00

abstract：:The Fifth International Workshop on the CCN Family of Genes was held in Toronto October 18-22, 2008. This bi-annual workshop provides a unique opportunity for the presentation and discussion of cutting edge research in the CCN field. The CCN family members have emerged as extracellular matrix associated proteins which...

journal_title：Journal of cell communication and signaling

authors： Irvine AE,Perbal B,Yeger H

更新日期：2008-12-01 00:00:00

abstract：:Tumor cells release extracellular vesicles (EVs) into the tumor microenvironment that may facilitate malignant progression and metastasis. Breast carcinoma EVs express high levels of the thrombospondin-1 and signal regulatory protein-α receptor CD47, which is the target of several experimental therapeutics currently i...

journal_title：Journal of cell communication and signaling

authors： Kaur S,Elkahloun AG,Singh SP,Arakelyan A,Roberts DD

更新日期：2018-03-01 00:00:00

abstract：:Glutamine (gln) metabolism has emerged as a cancer therapeutic target in past few years, however, the effect of gln-deprivation of bCSCs remains elusive in breast cancer. In this study, effect of glutamine on stemness and differentiation potential of bCSCs isolated from MCF-7 and MDAMB-231 were studied. We have shown ...

journal_title：Journal of cell communication and signaling

authors： Jariyal H,Gupta C,Andhale S,Gadge S,Srivastava A

更新日期：2021-01-28 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat accumulates in the liver of patients without a prior history of alcohol abuse. The most severe form, nonalcoholic steatohepatitis (NASH), often leads to hepatic fibrosis and cirrhosis with ensuing complications. To date, there is no pharmacologic tr...

journal_title：Journal of cell communication and signaling

authors： Wu W,Hu X,Zhou X,Klenotic PA,Zhou Q,Lin Z

更新日期：2018-03-01 00:00:00

abstract：:Hepatoblastoma (HB) is one of the most common liver malignancies in children, while the molecular basis of the disease is largely unknown. Therefore, this study aims to explore the key genes and molecular mechanisms of the pathogenesis of HB using a bioinformatics approach. The gene expression dataset GSE131329 was us...

journal_title：Journal of cell communication and signaling

authors： Aghajanzadeh T,Tebbi K,Talkhabi M

更新日期：2020-10-13 00:00:00

abstract：:The expression of the CCN family of matricellular proteins is highly dysregulated in connective tissue pathologies such as fibrosis and highly metastatic cancers. Strategies targeting members of this family, especially CCN2, are under development as novel therapeutic approaches to highly metastatic cancers such as pan...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2016-06-01 00:00:00

abstract：:We recently reported that transgenic mice with cardiac-restricted overexpression of CCN2/CTGF have substantially increased tolerance towards ischemia/reperfusion injury. The purpose of this study was to investigate to what extent fully differentiated cardiac myocytes are direct targets of CCN2, and to resolve the sign...

journal_title：Journal of cell communication and signaling

authors： Moe IT,Pham TA,Hagelin EM,Ahmed MS,Attramadal H

更新日期：2013-03-01 00:00:00

abstract：:Human bronchial epithelial cells exposed to synthetic double-stranded RNA (poly I:C) exhibited increased IL-6 and RANTES secretion and TLR2 expression that was inhibited following TLR3 silencing. Increased NF-κB and Stat3 phosphorylation were detected after poly I:C exposure and pretreatment with neutralizing antibody...

journal_title：Journal of cell communication and signaling

authors： Melkamu T,Kita H,O'Grady SM

更新日期：2013-06-01 00:00:00

abstract：:The growth regulating factor CTGF/CCN-2 is an integral factor in growth and development, connective tissue maintenance, wound repair and cell cycle regulation. It has recently been reported that CTGF/CCN-2 is involved in very early development having been detected in early notochord formation in zebrafish using CTGF/C...

journal_title：Journal of cell communication and signaling

authors： Erwin WM

更新日期：2008-12-01 00:00:00

abstract：:Inflammation is a crucial component in the pathogenesis of many vascular diseases, such as atherosclerosis and diabetes. Inflammasomes are intracellular signalling complexes whose activation promotes inflammation. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) is a patte...

journal_title：Journal of cell communication and signaling

authors： Kinnunen K,Piippo N,Loukovaara S,Hytti M,Kaarniranta K,Kauppinen A

更新日期：2017-09-01 00:00:00

abstract：:Connexin43 (Cx43) gap junctions expressed in astrocytes can significantly impact neuronal survival in stroke. However, little is known regarding Cx43 spatial and temporal expression during the initial stages of brain ischemia. Using immunohistochemistry and Western blot analysis, we examined Cx43 spatial and temporal ...

journal_title：Journal of cell communication and signaling

authors： Freitas-Andrade M,She J,Bechberger J,Naus CC,Sin WC

更新日期：2018-03-01 00:00:00

abstract：:Fibrotic diseases are a significant cause of mortality. It is being increasingly appreciated that the cellular microenvironment plays a key role in promoting pathological fibrosis. A previous Bits and Bytes described an elegant series of experiments published by Bruce Riser and colleagues (Am J Pathol. 2009: 174:1725-...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2015-03-01 00:00:00

abstract：:The lectin from Canavalia ensiformis (Concanavalin-A, ConA), one of the most abundant lectins known, enables one to mimic biological lectin/carbohydrate interactions that regulate extracellular matrix protein recognition. As such, ConA is known to induce membrane type-1 matrix metalloproteinase (MT1-MMP) which express...

journal_title：Journal of cell communication and signaling

authors： Sina A,Proulx-Bonneau S,Roy A,Poliquin L,Cao J,Annabi B

更新日期：2010-03-01 00:00:00

abstract：:It is well-established that the expression of CCN family of matricellular proteins is altered in essentially all cancers and, hence, targeting these proteins may be a novel therapeutic approach to treating these diseases. For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appe...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2013-06-01 00:00:00

abstract：:The CCN family of proteins consists of six members with conserved structural features. These proteins play several roles in the physiology and pathology of cells. Among the pathological roles of the CCN family, one of the most important and controversial ones is their role in the expansion and metastasis of cancer. Up...

journal_title：Journal of cell communication and signaling

authors： Ohgawara T,Kubota S,Kawaki H,Kurio N,Abd El Kader T,Hoshijima M,Janune D,Shimo T,Perbal B,Sasaki A,Takigawa M

更新日期：2011-12-01 00:00:00

abstract：:Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase ac...

journal_title：Journal of cell communication and signaling

authors： Zibara K,Zeidan A,Bjeije H,Kassem N,Badran B,El-Zein N

更新日期：2017-03-01 00:00:00