Proteasome inhibitors in cancer therapy.

abstract：:Because of differences in the downstream signaling patterns of its pathways, the role of the human epidermal growth factor family of receptors (HER) in promoting cell growth and survival is cell line and context dependent. Using two model cell lines, we have studied how the regulatory interaction network among the key...

journal_title：Journal of cell communication and signaling

authors： Speth Z,Islam T,Banerjee K,Resat H

更新日期：2017-12-01 00:00:00

abstract：:Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase ac...

journal_title：Journal of cell communication and signaling

authors： Zibara K,Zeidan A,Bjeije H,Kassem N,Badran B,El-Zein N

更新日期：2017-03-01 00:00:00

abstract：:The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and transduced by various intracellular signal pathways is modulated by the IGF Binding Proteins (IGFBPs). Among all the IGFBPs, IGFBP-2 has been implicated in the regulation of IGF activity in most tissue and organs. Besides b...

journal_title：Journal of cell communication and signaling

authors： Yau SW,Azar WJ,Sabin MA,Werther GA,Russo VC

更新日期：2015-06-01 00:00:00

abstract：:Tumor cells release extracellular vesicles (EVs) into the tumor microenvironment that may facilitate malignant progression and metastasis. Breast carcinoma EVs express high levels of the thrombospondin-1 and signal regulatory protein-α receptor CD47, which is the target of several experimental therapeutics currently i...

journal_title：Journal of cell communication and signaling

authors： Kaur S,Elkahloun AG,Singh SP,Arakelyan A,Roberts DD

更新日期：2018-03-01 00:00:00

abstract：:The expression of the CCN family of matricellular proteins is highly dysregulated in connective tissue pathologies such as fibrosis and highly metastatic cancers. Strategies targeting members of this family, especially CCN2, are under development as novel therapeutic approaches to highly metastatic cancers such as pan...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2016-06-01 00:00:00

abstract：:Erlotinib is an oral tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) pathway. Although our previous study has proved the efficacy of Erlotinib in head and neck squamous cell carcinoma (HNSCC), it has also demonstrated poor clinical response rates and disappointing results in clinical trials for HN...

journal_title：Journal of cell communication and signaling

authors： Zheng Y,Song A,Zhou Y,Zhong Y,Zhang W,Wang C,Ding X,Du Y,Zhang W,Li G,Wu H,Wu Y,Song X

更新日期：2020-12-01 00:00:00

abstract：:Mice lacking the pro-adhesive matricellular protein connective tissue growth factor (CTGF/CCN2) display an embryonic lethal phenotype due to defects in bone and cartilage. However, the specific role of CCN2 in skin development is unknown. Here, we generated mice deleted for CCN2 in the entire body (using a cre/lox sys...

journal_title：Journal of cell communication and signaling

authors： Liu S,Leask A

更新日期：2011-08-01 00:00:00

abstract：:It is well-established that the expression of CCN family of matricellular proteins is altered in essentially all cancers and, hence, targeting these proteins may be a novel therapeutic approach to treating these diseases. For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appe...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2013-06-01 00:00:00

abstract：:The discovery of the gap junction structure, its functions and the family of the "connexin" genes, has been basically ignored by the major biological disciplines. These connexin genes code for proteins that organize to form membrane-associated hemi-channels, "connexons", co-join with the connexons of neighboring cells...

journal_title：Journal of cell communication and signaling

authors： Trosko JE

更新日期：2011-03-01 00:00:00

abstract：:Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyr...

journal_title：Journal of cell communication and signaling

authors： Yelamanchi SD,Jayaram S,Thomas JK,Gundimeda S,Khan AA,Singhal A,Keshava Prasad TS,Pandey A,Somani BL,Gowda H

更新日期：2016-03-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat accumulates in the liver of patients without a prior history of alcohol abuse. The most severe form, nonalcoholic steatohepatitis (NASH), often leads to hepatic fibrosis and cirrhosis with ensuing complications. To date, there is no pharmacologic tr...

journal_title：Journal of cell communication and signaling

authors： Wu W,Hu X,Zhou X,Klenotic PA,Zhou Q,Lin Z

更新日期：2018-03-01 00:00:00

abstract：:We recently reported that transgenic mice with cardiac-restricted overexpression of CCN2/CTGF have substantially increased tolerance towards ischemia/reperfusion injury. The purpose of this study was to investigate to what extent fully differentiated cardiac myocytes are direct targets of CCN2, and to resolve the sign...

journal_title：Journal of cell communication and signaling

authors： Moe IT,Pham TA,Hagelin EM,Ahmed MS,Attramadal H

更新日期：2013-03-01 00:00:00

abstract：:Hepatocyte exosomes (ExoHep) are proposed to mediate physiological or pathophysiological signaling in a variety of hepatic target cells. ExoHep were purified from the medium of primary mouse hepatocytes or AML12 cells and characterized as ~100 nm nanovesicles that were positive for proteins commonly found in exosomes ...

journal_title：Journal of cell communication and signaling

authors： Chen L,Chen R,Kemper S,Brigstock DR

更新日期：2018-03-01 00:00:00

abstract：:In breast cancer cells, the linoleic acid (LA), an ω-6 essential polyunsaturated fatty acid, induces a variety of biological processes, including migration and invasion. Extracellular vesicles (EVs) are structures released by normal and malignant cells into extracellular space, and their function is dependent on their...

journal_title：Journal of cell communication and signaling

authors： Leal-Orta E,Ramirez-Ricardo J,Cortes-Reynosa P,Galindo-Hernandez O,Salazar EP

更新日期：2019-06-01 00:00:00

abstract：:Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic domain. These adjacent domains bind to extracellular matrix proteins (type I collagen, fibronectin, tenascin-C, and laminin γ2), and BM...

journal_title：Journal of cell communication and signaling

authors： Kudo A,Kii I

更新日期：2018-03-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) and connective tissue growth factor (CTGF) have been described to induce the production of extracellular matrix (ECM) proteins and have been reported to be increased in different fibrotic disorders. Skeletal muscle fibrosis is a common feature of Duchenne muscular dystrophy (...

journal_title：Journal of cell communication and signaling

authors： Mezzano V,Cabrera D,Vial C,Brandan E

更新日期：2007-12-01 00:00:00

abstract：:The Kallikrein Kinin System (KKS) is a vasoactive peptide system with known functions in the maintenance of tissue homeostasis, renal function and blood pressure. The main effector peptide of KKS is Bradykinin (BK). This ligand has two receptors: a constitutive B2 receptor (B2R), which has been suggested to have anti-...

journal_title：Journal of cell communication and signaling

authors： Acuña MJ,Salas D,Córdova-Casanova A,Cruz-Soca M,Céspedes C,Vio CP,Brandan E

更新日期：2018-09-01 00:00:00

abstract：:Glutamine (gln) metabolism has emerged as a cancer therapeutic target in past few years, however, the effect of gln-deprivation of bCSCs remains elusive in breast cancer. In this study, effect of glutamine on stemness and differentiation potential of bCSCs isolated from MCF-7 and MDAMB-231 were studied. We have shown ...

journal_title：Journal of cell communication and signaling

authors： Jariyal H,Gupta C,Andhale S,Gadge S,Srivastava A

更新日期：2021-01-28 00:00:00

abstract：:Inflammation is a crucial component in the pathogenesis of many vascular diseases, such as atherosclerosis and diabetes. Inflammasomes are intracellular signalling complexes whose activation promotes inflammation. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) is a patte...

journal_title：Journal of cell communication and signaling

authors： Kinnunen K,Piippo N,Loukovaara S,Hytti M,Kaarniranta K,Kauppinen A

更新日期：2017-09-01 00:00:00

abstract：:The growth regulating factor CTGF/CCN-2 is an integral factor in growth and development, connective tissue maintenance, wound repair and cell cycle regulation. It has recently been reported that CTGF/CCN-2 is involved in very early development having been detected in early notochord formation in zebrafish using CTGF/C...

journal_title：Journal of cell communication and signaling

authors： Erwin WM

更新日期：2008-12-01 00:00:00

abstract：:The Fifth International Workshop on the CCN Family of Genes was held in Toronto October 18-22, 2008. This bi-annual workshop provides a unique opportunity for the presentation and discussion of cutting edge research in the CCN field. The CCN family members have emerged as extracellular matrix associated proteins which...

journal_title：Journal of cell communication and signaling

authors： Irvine AE,Perbal B,Yeger H

更新日期：2008-12-01 00:00:00

abstract：:Key pathways like insulin signaling, AMP activated kinase (AMPK) activation and inflammatory signaling are involved in the complex pathological network of hepatic insulin resistance. Our aim is to investigate whether grape seed proanthocyanidins (GSP) and metformin (MET) target any of these pathways in insulin resista...

journal_title：Journal of cell communication and signaling

authors： Yogalakshmi B,Bhuvaneswari S,Sreeja S,Anuradha CV

更新日期：2014-03-01 00:00:00

abstract：:Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epi...

journal_title：Journal of cell communication and signaling

authors： Fiaturi N,Russo JW,Nielsen HC,Castellot JJ Jr

更新日期：2018-03-01 00:00:00

abstract：:Fibrotic diseases are a significant cause of mortality. It is being increasingly appreciated that the cellular microenvironment plays a key role in promoting pathological fibrosis. A previous Bits and Bytes described an elegant series of experiments published by Bruce Riser and colleagues (Am J Pathol. 2009: 174:1725-...

journal_title：Journal of cell communication and signaling

authors： Leask A

更新日期：2015-03-01 00:00:00

abstract：:In June 2015, Thomson Reuters informed our publisher Springer that the Journal of Cell Communication and Signaling, the official journal of the International CCN Society, « had been selected for coverage in Thomson Reuter's products and services. Beginning with V. 1 (1) 2007, this publication would be indexed and abst...

journal_title：Journal of cell communication and signaling

authors： Perbal B

更新日期：2015-09-01 00:00:00

abstract：:We have recently identified several novel ATP-independent inhibitors that target the extracellular signal-regulated kinase-2 (ERK2) protein and inhibit substrate phosphorylation. To further characterize these compounds, we describe the use of C. elegans as a model organism. C. elegans is recognized as a versatile and ...

journal_title：Journal of cell communication and signaling

authors： Chen F,Mackerell AD Jr,Luo Y,Shapiro P

更新日期：2008-12-01 00:00:00

abstract：:Mitogen activated protein kinases (MAPKs) play an important role in activation, differentiation and proliferation of macrophages. Macrophages, upon activation, produce large amounts of nitric oxide that inhibit the growth of variety of microorganisms and tumor cells. This nitric oxide which is known to interfere with ...

journal_title：Journal of cell communication and signaling

authors： Narang H,Dhariwala FA,Krishna M

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to investigate the effects of homocysteine (Hcy), a risk factor for cardiovascular diseases, hypertension, stroke and obesity, on expression of CD36 that regulates uptake of oxidized low-density lipoprotein (Ox-LDL) by adipocytes and differentiation of 3T3-L1 cells to adipocytes. Cell viabili...

journal_title：Journal of cell communication and signaling

authors： Mentese A,Alver A,Sumer A,Demir S

更新日期：2016-03-01 00:00:00

abstract：:CCN3 is a member of the CCN family of cell growth and differentiation regulators that play key roles during embryonic development, and are associated with severe human pathologies. The level of CCN genes' expression is of prognostic value in several types of tumors. In the present manuscript, we report the isolation a...

journal_title：Journal of cell communication and signaling

authors： Lazar N,Manara C,Navarro S,Bleau AM,Llombart-Bosch A,Scotlandi K,Planque N,Perbal B

更新日期：2007-09-01 00:00:00

abstract：:Fibroblast growth factor 1 (FGF-1) is the first FGF family member, and it induces proliferation of fibroblasts and other types of the cells. However, recent studies are uncovering unexpected functions of this molecule. Our previous study redefined this growth factor as a catabolic molecule produced in cartilage upon m...

journal_title：Journal of cell communication and signaling

authors： Elseoudi A,Nishida T,Mizukawa T,Hattori T,Kawata K,Taha EA,Takigawa M,Kubota S

更新日期：2021-01-04 00:00:00