Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic?

Abstract:

:Fibrotic diseases are a significant cause of mortality. It is being increasingly appreciated that the cellular microenvironment plays a key role in promoting pathological fibrosis. A previous Bits and Bytes described an elegant series of experiments published by Bruce Riser and colleagues (Am J Pathol. 2009: 174:1725-34) that showed that CCN3 (nov) antagonizes the fibrogenic effects of CCN2.and hence could represent a novel anti-fibrotic therapy. They have continued their excellent work and have recently used the ob/ob mouse as a model of obesity and diabetic nephropathy to show that CCN3 could block the induction of profibrotic gene expression, fibrosis and loss of kidney function (Am J Pathol. 2014;184:2908-21). Also, reversal of fibrosis was observed. Thus this paper provides strong evidence that CCN3 may be used as a novel therapy to treat diabetes caused by obesity.

journal_name

J Cell Commun Signal

authors

Leask A

doi

10.1007/s12079-015-0281-y

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

97-8

issue

1

eissn

1873-9601

issn

1873-961X

journal_volume

9

pub_type

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