Abstract:
:PEGylation is a biochemical modification process of bioactive molecules with polyethylene glycol (PEG), which lends several desirable properties to proteins/peptides, antibodies, and vesicles considered to be used for therapy or genetic modification of cells. However, PEGylation of proteins is a complex process and can be carried out using more than one strategy that depends on the nature of the protein and the desired application. Proteins of interest are covalently conjugated or non-covalently complexed with inert PEG strings. Purification of PEGylated protein is another critical step, which is mainly carried out based on electrostatic interactions or molecular sizes using chromatography. Several PEGylated drugs are being used for diseases like anemia, kidney disease, multiple sclerosis, hemophilia and cancers. With the advancement and increased specificity of the PEGylation process, the world of drug therapy, and specifically cancer therapy could benefit by utilizing this technique to create more stable and non-immunogenic therapies. In this article we describe the structure and functions of PEGylation and how this chemistry helps in drug discovery. Moreover, special emphasis has been given to CCN-family proteins that can be targeted or used as therapy to prevent or block cancer progression through PEGylation technology.
journal_name
J Cell Commun Signaljournal_title
Journal of cell communication and signalingauthors
Gupta V,Bhavanasi S,Quadir M,Singh K,Ghosh G,Vasamreddy K,Ghosh A,Siahaan TJ,Banerjee S,Banerjee SKdoi
10.1007/s12079-018-0492-0subject
Has Abstractpub_date
2019-09-01 00:00:00pages
319-330issue
3eissn
1873-9601issn
1873-961Xpii
10.1007/s12079-018-0492-0journal_volume
13pub_type
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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