Abstract:
:Research over the past few years has highlighted the ability of the unfolded protein response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under both physiological and pathological conditions. The endoplasmic reticulum (ER) adapts to endogenous and exogenous stressors by expanding its protein-folding capacity and by stimulating protective processes such as autophagy and antioxidant responses. Although it is clear that severe ER stress can elicit cell death, several recent studies have shown that low levels of ER stress may actually be beneficial to cells by eliciting an adaptive UPR that 'preconditions' the cell to a subsequent lethal insult; this process is called ER hormesis. The findings have important implications for the treatment of a wide variety of diseases associated with defective proteostasis, including neurodegenerative diseases, diabetes, and cancer. Here, we review the physiological and pathological functions of the ER, with a particular focus on the molecular mechanisms that lead to ER hormesis and cellular protection, and discuss the implications for disease treatment.
journal_name
J Cell Commun Signaljournal_title
Journal of cell communication and signalingauthors
Mollereau B,Manié S,Napoletano Fdoi
10.1007/s12079-014-0251-9subject
Has Abstractpub_date
2014-12-01 00:00:00pages
311-21issue
4eissn
1873-9601issn
1873-961Xjournal_volume
8pub_type
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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doi:10.1007/s12079-015-0306-6
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-015-0281-y
更新日期:2015-03-01 00:00:00
abstract::It is well-established that the expression of CCN family of matricellular proteins is altered in essentially all cancers and, hence, targeting these proteins may be a novel therapeutic approach to treating these diseases. For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appe...
journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-012-0189-8
更新日期:2013-06-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-011-0133-3
更新日期:2011-12-01 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-011-0129-z
更新日期:2011-08-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-013-0207-5
更新日期:2013-12-01 00:00:00
abstract::The Rsu1 protein contributes to cell adhesion and migration via its association with the adaptor complex of Integrin linked kinase (ILK), PINCH, and Parvin (IPP), which binds to the cytoplasmic domain of β1 integrins joining integrins to the actin cytoskeleton. Rsu1 binding to PINCH in the IPP complex is required for ...
journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-018-00504-4
更新日期:2019-09-01 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-012-0183-1
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-013-0210-x
更新日期:2014-03-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-017-0432-4
更新日期:2018-03-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-020-00600-4
更新日期:2021-01-04 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章,评审
doi:10.1007/s12079-018-0492-0
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abstract::Hepatocyte exosomes (ExoHep) are proposed to mediate physiological or pathophysiological signaling in a variety of hepatic target cells. ExoHep were purified from the medium of primary mouse hepatocytes or AML12 cells and characterized as ~100 nm nanovesicles that were positive for proteins commonly found in exosomes ...
journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-017-0421-7
更新日期:2018-03-01 00:00:00