Abstract:
:Mice lacking the pro-adhesive matricellular protein connective tissue growth factor (CTGF/CCN2) display an embryonic lethal phenotype due to defects in bone and cartilage. However, the specific role of CCN2 in skin development is unknown. Here, we generated mice deleted for CCN2 in the entire body (using a cre/lox system in which CCN2 is deleted in the entire body due to the presence of a constitutively expressed cre recombinase). We found that CCN2 was not required for the development of skin as defined by skin thickness measurements, trichrome staining and immunostaining with anti-CD31 (to detect endothelial cells) and anti-α-SMA (to detect smooth muscle cells and pericytes) antibodies. Thus, although recently we have shown that CCN2 is required for fibrogenesis in postnatal mice, CCN2 is not required for skin development during embryogenesis.
journal_name
J Cell Commun Signaljournal_title
Journal of cell communication and signalingauthors
Liu S,Leask Adoi
10.1007/s12079-011-0129-zsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
179-82issue
3eissn
1873-9601issn
1873-961Xjournal_volume
5pub_type
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