CCN5 Expression in mammals. III. Early embryonic mouse development.

Abstract:

:CCN proteins play crucial roles in development, angiogenesis, cell motility, matrix turnover, proliferation, and other fundamental cell processes. Early embryonic lethality in CCN5 knockout and over-expressing mice led us to characterize CCN5 distribution in early development. Previous papers in this series showed that CCN5 is expressed widely in mice from E9.5 to adult; however, its distribution before E9.5 has not been studied. To fill this gap in our knowledge of CCN5 expression in mammals, RT-PCR was performed on preimplantation murine embryos: 1 cell, 2 cell, 4 cell, early morula, late morula, and blastocyst. CCN5 mRNA was not detected in 1, 2, or 4 cell embryos. It was first detected at the early morula stage and persisted to the preimplantation blastocyst stage. Immunohistochemical staining showed widespread CCN5 expression in post-implantation blastocysts (E4.5), E5.5, E6.5, and E7.5 stage embryos. Consistent with our previous study on E9.5 embryos, this expression was not limited to a particular germ layer or cell type. The widespread distribution of CCN5 in early embryos suggests a crucial role in development.

journal_name

J Cell Commun Signal

authors

Myers RB,Rwayitare K,Richey L,Lem J,Castellot JJ Jr

doi

10.1007/s12079-012-0176-0

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

217-23

issue

4

eissn

1873-9601

issn

1873-961X

journal_volume

6

pub_type

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