Abstract:
:CCN proteins play crucial roles in development, angiogenesis, cell motility, matrix turnover, proliferation, and other fundamental cell processes. Early embryonic lethality in CCN5 knockout and over-expressing mice led us to characterize CCN5 distribution in early development. Previous papers in this series showed that CCN5 is expressed widely in mice from E9.5 to adult; however, its distribution before E9.5 has not been studied. To fill this gap in our knowledge of CCN5 expression in mammals, RT-PCR was performed on preimplantation murine embryos: 1 cell, 2 cell, 4 cell, early morula, late morula, and blastocyst. CCN5 mRNA was not detected in 1, 2, or 4 cell embryos. It was first detected at the early morula stage and persisted to the preimplantation blastocyst stage. Immunohistochemical staining showed widespread CCN5 expression in post-implantation blastocysts (E4.5), E5.5, E6.5, and E7.5 stage embryos. Consistent with our previous study on E9.5 embryos, this expression was not limited to a particular germ layer or cell type. The widespread distribution of CCN5 in early embryos suggests a crucial role in development.
journal_name
J Cell Commun Signaljournal_title
Journal of cell communication and signalingauthors
Myers RB,Rwayitare K,Richey L,Lem J,Castellot JJ Jrdoi
10.1007/s12079-012-0176-0subject
Has Abstractpub_date
2012-12-01 00:00:00pages
217-23issue
4eissn
1873-9601issn
1873-961Xjournal_volume
6pub_type
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of cell communication and signaling
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更新日期:2011-08-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章,评审
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journal_title:Journal of cell communication and signaling
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更新日期:2018-09-01 00:00:00
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journal_title:Journal of cell communication and signaling
pub_type: 杂志文章
doi:10.1007/s12079-015-0281-y
更新日期:2015-03-01 00:00:00
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journal_title:Journal of cell communication and signaling
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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更新日期:2007-12-01 00:00:00
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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journal_title:Journal of cell communication and signaling
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00