Abstract：
PURPOSE:To identify potential metabolic biomarkers for distinguishing malignant and benign thyroid nodules in children and adolescents using a metabolomics approach. METHODS:A total of 96 consecutive patients (median age 14.29 ± 2.31 years, range 9-18 years) who underwent thyroidectomy and 40 healthy controls were enrolled. Patients were assigned to the papillary thyroid carcinoma and benign thyroid adenoma groups according to postoperative pathologic biopsy. Plasma samples were preoperatively collected, and multivariate analysis was performed to identify differential metabolites. RESULTS:Papillary thyroid carcinoma could be distinguished not only from healthy serum but also from benign thyroid adenoma according to the metabolic profiles. A total of 17 metabolites were identified. Compared with those from benign thyroid adenoma patients and healthy controls, the metabolites from papillary thyroid carcinoma patients, including leucine, lactate, alanine, glycine, acetate, lysine and choline, were increased, while glucose was decreased. CONCLUSION:The metabolomics method based on proton nuclear magnetic resonance has great potential for identifying papillary thyroid carcinoma in children and adolescents. Lactate and glycine may be used as potential serum markers for the diagnosis of papillary thyroid carcinoma.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Zhou Q,Zhang LY,Xie C,Zhang ML,Wang YJ,Liu GHdoi
10.1007/s00383-019-04584-0subject
Has Abstractpub_date
2020-02-01 00:00:00pages
145-153issue
2eissn
0179-0358issn
1437-9813pii
10.1007/s00383-019-04584-0journal_volume
36pub_type
杂志文章abstract：PURPOSE:Laparoscopic-assisted anorectoplasty (LAARP) is considered to benefit the patients with vesico-prostatic fistula. The aim of this study is to present the details of our LAARP technique for improving the short- and long-term outcomes in the patients with high and intermediate types of anorectal malformations (AR...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04614-x
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:Primary spontaneous pneumothorax (PSP) is managed in accordance with the adult British Thoracic Society (BTS) guidelines due to lack of paediatric evidence and consensus. We aim to highlight the differences and provide a best practice surgical management strategy for PSP based on experience of two major paediat...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3787-8
更新日期：2015-12-01 00:00:00
abstract：:The interstitial cells of Cajal (ICC) play an important role in the control of gut motility. The recognition that the ICC cell membrane harbors the c-kit receptor (CD117) sparked rapid advancement in ICC research on the gut and certain pathologies using immunochemical and molecular methods. The question arises whether...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-004-1314-4
更新日期：2005-03-01 00:00:00
abstract：INTRODUCTION:Management of oesophageal atresia (OA) and trachea-oesophageal fistula (TOF) in babies of low birth weight is challenging especially when associated with other anomalies. Birth weight of <1500 g has previously formed part of a classification system designed to predict outcome, alongside the cardiac status ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3851-4
更新日期：2016-06-01 00:00:00
abstract：:Recurrent or chronic abdominal pain can be a challenging problem when conventional diagnostic studies fail to identify the cause. It is estimated that up to one-third of children suffer from abdominal pain, and in this population recurrent pain can be even more challenging. Although recurrent right lower quadrant (RLQ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1632-1
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:The aim of the German Network for Congenital Uro-REctal malformations (CURE-Net) is to collect data of affected patients with anorectal malformation (ARM) to investigate molecular causes, clinical implications and psychosocial outcome. The current issue was to examine the transition to adulthood in adults with ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3120-8
更新日期：2012-08-01 00:00:00
abstract：:We present the first two cases of acute neonatal appendicitis operated on through the laparoscopic approach. Acute neonatal appendicitis is uncommon and rarely considered by clinicians when assessing the neonatal acute abdomen. Our two cases demonstrate the potential value of diagnostic laparoscopy in the acute neonat...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-011-2972-7
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:We assessed the impact of intestinal transplantation on Japanese pediatric patients with intestinal failure with data from the Japanese intestinal transplant registry. METHODS:Standardized forms were sent to all known intestinal transplantation programs, requesting information on transplants performed bet...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-013-3392-7
更新日期：2013-10-01 00:00:00
abstract：:There are few publications about urolithiasis of the new born baby and infant (UNI). The UNI represents 20% of the pediatric urolithiasis. The etiologies in this age group are chiefly dominated by the urinary-tract infections and metabolic abnormalities. The purpose of this paper was to investigate the epidemiological...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-1889-7
更新日期：2007-04-01 00:00:00
abstract：:Glicentin, the main component of enteroglucagon, has trophic effects on intestinal mucosa. It may also have an inhibitory effect on extraintestinal invasion of enteric bacteria. We have established an in vitro bioassay system for determining the effects of recombinant human glicentin on bacterial internalization by co...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1895-9
更新日期：2007-06-01 00:00:00
abstract：INTRODUCTION:Objectively evaluating the lack of bowel control (fecal incontinence) continues to be a challenge. Many have attempted to measure the severity of fecal incontinence and to evaluate its impact on the quality of life by developing standardized scoring systems. Some of these systems have been validated but no...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-016-3909-y
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Experience with male cloaca (MC), a single opening in perineum for passage of urine and meconeum is described. METHODS:Cases of MC were ambispectively studied, prospectively from July 2007 to April 2015 and retrospectively for last three decades. RESULTS:Seven cases of MC were identified, between the ages of ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3738-4
更新日期：2015-08-01 00:00:00
abstract：:Since January 2006, robotic assistance has been used for performing minimal invasive laparoscopic fundoplications in children. These patients were compared with those operated on with either the open surgical technique or the laparoscopic procedure. The first six children operated on with a fundoplication using the op...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1817-2
更新日期：2007-02-01 00:00:00
abstract：:With widespread use of antenatal ultrasound, an increasing number of urinary-tract lesions are being detected, and the clinician is called upon to make management decisions. Parenchymal lesions of the kidney pose a special challenge because of the associated risk of the occurrence of malignancy. A case of an antenatal...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0833-0
更新日期：2003-04-01 00:00:00
abstract：:The management of Hirschsprung's disease (HD) has made dramatic strides over the last 20 years. Research into the embryological development and migration of ganglion cell has enabled a greater understanding of the pathogenesis of the disease. Coupled with new techniques in surgery, such as laparoscopy-assisted pull-th...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-005-1551-1
更新日期：2005-10-01 00:00:00
abstract：:In contrast to adults, calcium carbonate gallstones are relatively common in children. Their pathogenesis is poorly understood. Cystic duct obstruction promotes calcium carbonate formation in bile and increases gallbladder mucin production. We tested the hypothesis that mucin producing epithelial cells would be increa...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1867-5
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Currently, there are two well-established methods of bowel lengthening in patients with short bowel syndrome (SBS)-longitudinal intestinal lengthening and tailoring (LILT) and serial transverse enteroplasty (STEP) [1-4]. Both procedures may carry a high reported morbidity and mortality of 30.2% and 14.4%, re...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04767-0
更新日期：2021-01-01 00:00:00
abstract：:The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01371914
更新日期：1997-01-01 00:00:00
abstract：AIM OF THE STUDY:Liver retraction during laparoscopic fundoplication is important for obtaining an optimal space. Several methods have been developed, but the risks and benefits are unclear. We compared three different approaches and evaluated their safety and utility. METHODS:Forty-three neurologically impaired patie...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04646-8
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine if there is a difference between complications for totally implantable central venous catheters (ports) and tunnelled external central venous catheters (external CVCs) that result in early removal of the central venous catheter (CVC) in children and adolescents with acute ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3213-4
更新日期：2012-12-01 00:00:00
abstract：:Pharyngeal perforations are uncommon in children and are usually secondary to instrumentation or external penetrating injuries. A delay in management can lead to life-threatening complications such as retropharyngeal abscess, mediastinitis, and airway compromise. We report three children who had pharyngeal perforation...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1447-0
更新日期：2005-06-01 00:00:00
abstract：:Bronchogenic cyst (BC), which develops from abnormal budding of the tracheal diverticulum or ventral foregut, is a congenital bronchopulmonary malformation. Localization of the BC varies depending on the level of the abnormal budding. Thoracic or abdominal-sited diaphragmatic lesions are the rarest presentations of th...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-008-2187-8
更新日期：2008-08-01 00:00:00
abstract：:Confirmation of the clinical diagnosis of Hirschsprung's disease on standard rectal suction biopsy requires demonstration of aganglionosis in 60 adequate serial sections of submucosa. Positive staining for acetylcholinesterase (AChE), demonstrating an increase in nerve fibres within the lamina propria, muscularis muco...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050237
更新日期：1998-01-01 00:00:00
abstract：:Congenital lumbar hernia (CLH) is a rare anomaly with only 45 cases reported in the English-language literature. This paper describes nine patients with CLH treated in our unit. Unusual features included the relatively high incidence of inferior lumbar hernia, presentation at the age of 6 years in one case, and an ass...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050048
更新日期：2000-01-01 00:00:00
abstract：:Polyps in gastrointestinal tract are mostly benign and result from hamartomas or lymphoid hyperplasia of submucosa. They usually occur as isolated lesions in children and are referred to as juvenile polyps. Multiple polyps with inherited origin are called polyposis and can be seen as a part of the syndrome. The polyps...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-020-04621-3
更新日期：2020-04-01 00:00:00
abstract：:The incidence of gastroschisis appears to be rising in developed nations, with epidemiological studies indicating association with young maternal age and smoking. Is there an association between maternal smoking and the development of complicated gastroschisis? A retrospective population-based review of all cases of g...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1926-6
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3833-6
更新日期：2016-03-01 00:00:00
abstract：:The presacral cystic teratoma in an infant is reported. The cyst consisted solely of central nervous system tissue. This pathologic finding is extremely rare. A review of the literature reveals no previous report of a teratoma arising in this manner. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0831-2
更新日期：2002-12-01 00:00:00
abstract：PURPOSE:To evaluate early postoperative results in a case controlled study following clinical use of stem cells in extrahepatic biliary atresia (EHBA). METHODS:From July 2005 to March 2008, 30 cases of suspected EHBA were divided in two groups in an intervention study. Group A received autologous mononuclear bone marr...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2712-4
更新日期：2011-01-01 00:00:00
abstract：:It is unknown whether noncomplicated acute appendicitis cause bacterial translocation. In this study, we aimed to test development of the bacterial translocation in the patients who were operated for acute appendicitis. In this prospective study, 10 control patients who underwent elective operations because of other r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1899-5
更新日期：2007-06-01 00:00:00
