Abstract:
:The interstitial cells of Cajal (ICC) play an important role in the control of gut motility. The recognition that the ICC cell membrane harbors the c-kit receptor (CD117) sparked rapid advancement in ICC research on the gut and certain pathologies using immunochemical and molecular methods. The question arises whether ICC exist in the upper urinary tract (UUT) and trigger motility. The present study analyzed the distribution of the c-kit receptor in the normal human UUT compared with various species. Immunohistochemistry (alkaline-phosphatase-anti-alkaline-phosphatase technique, immunofluorescence) was applied on serial sections using monoclonal and polyclonal antibodies recognizing the c-kit receptor. C-kit staining was compared with standard endothelial, epithelial, neurogenic, histiocytic, mast cell, and smooth muscle markers, as well as a negative control. Normal proximal, middle, and distal ureter segments were analyzed in rodents, carnivores, porcines, cow, and humans. In all species the c-kit receptor was detected in either round or spindle-shaped cells. Because of their antigenic profile, the round cells were identified as mast cells occurring in all layers of the ureteral wall except the urothelium and were more frequent in humans. In contrast, the population of spindle-shaped cells was marked only by anti-c-kit receptor antibodies, thus resembling ICC. These ICC-like cells were found among the inner and outer smooth muscle layers and in the lamina propria of all species. In humans, spindle-shaped cells were also found vertically oriented within the urothelium. Our morphological data present for the first time the distribution of ICC in the UUT of various species. The ubiquitous distribution in the entire pyeloureteral complex provides strong evidence that ICC generate electrical pacemaker activity within the UUT as an intrinsic system. Animal studies may help to understand the physiological importance of these ICC-like cells. The significance of these findings needs to be evaluated by functional studies and investigations of certain congenital pathologies with disturbance of the urinary outflow.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Metzger R,Schuster T,Till H,Franke FE,Dietz HGdoi
10.1007/s00383-004-1314-4subject
Has Abstractpub_date
2005-03-01 00:00:00pages
169-74issue
3eissn
0179-0358issn
1437-9813journal_volume
21pub_type
杂志文章abstract::Neonates with congenital tracheal stenosis (CTS) sometimes develop respiratory distress and may be difficult to intubate. We used balloon tracheoplasty with a rigid bronchoscope for emergency airway management in neonates with symptomatic CTS. Herein, we describe the balloon tracheoplasty procedure and the early outco...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-014-3571-1
更新日期:2014-09-01 00:00:00
abstract::Clear cell sarcoma of the kidney (CCSK) is an uncommon neoplasm that accounts for almost 3 % of pediatric renal tumors. Cavoatrial tumor thrombosis is very rare and because of poor response to chemotherapy, invasive surgical interventions such as open heart surgery may be indicated. A 6-year-old girl with CCSK of righ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3160-0
更新日期:2012-11-01 00:00:00
abstract::Congenital obstructive uropathy is associated with significant morbidity and mortality in the human neonate. The pathophysiology of congenital obstructive uropathy is poorly understood. There are very few experimental models of prenatal obstruction of the urinary tract, except in the fetal lamb or inbred rats. Prenata...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-004-1322-4
更新日期:2005-03-01 00:00:00
abstract::The loss of esophageal length in long-gap esophageal atresia or obliteration of the esophageal lumen due to stricture may require major operative reconstruction. A number of procedures have been developed to allow anatomic replacement of the esophagus. The gastric transposition requires a single cervical anastomosis a...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-010-2736-9
更新日期:2010-12-01 00:00:00
abstract::We report a rare case of massive haematochezia due to hookworm infestation that required two laparotomies before the cause of bleeding could be diagnosed. The need to consider this parasite as a possible cause of gut bleeding in endemic countries is stressed, as early recognition may avoid unnecessary investigations a...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF00497827
更新日期:1996-06-01 00:00:00
abstract::Anorectal malformations (ARM) remain a significant birth defect with geographic variation in incidence, individual phenotypes and regional geographic subtypes. Although early studies indicated a low incidence in Black patients, there is a great paucity of knowledge as to the types, frequency and incidence of ARMs enco...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-008-2131-y
更新日期:2008-06-01 00:00:00
abstract::Inflammatory pseudotumors (IPT) are uncommon mass lesions arising most typically in the lungs of young adults. These tumors are so named because of the difficulty in distinguishing them preoperatively from malignant lesions. IPT are characterized histologically by localized fibrous proliferations with infiltration by ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830000518
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:The loss of normal anatomic barriers in neonates with congenital diaphragmatic hernia (CDH) can predispose children to gastroesophageal reflux (GER). In an attempt to improve post-operative feeding, we have added a modified anterior fundoplication to restore natural gastric and esophageal positioning. METHODS:...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2411-1
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:The aim of the German Network for Congenital Uro-REctal malformations (CURE-Net) is to collect data of affected patients with anorectal malformation (ARM) to investigate molecular causes, clinical implications and psychosocial outcome. The current issue was to examine the transition to adulthood in adults with ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3120-8
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:To describe a modification of PATIO repair for urethrocutaneous fistula repair and evaluate its outcome. METHODS:We studied 15 boys who underwent modified PATIO repair from Jan 2010 to Sept 2015. Parameters studied included age, type of hypospadias, age at first urethroplasty, hypospadias repair technique, ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-016-3983-1
更新日期:2017-01-01 00:00:00
abstract::Congenital lung lesions are diagnosed antenatally in the majority of cases. Postnatal management includes chest radiography and CT-scanning, followed by either surgical resection or CT surveillance. Pre-operatively, lesions are often "labelled" as CCAM (and the Stocker classification incorrectly applied), sequestratio...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2201-1
更新日期:2008-09-01 00:00:00
abstract::Intussusception is the commonest surgical complication of Henoch-Sch onlein purpura (HSP), occurring in 1.3%-13.6% of affected children. Colo-colic intussusception is a rare occurrence in HSP, with only three other reported cases. Intussusception in HSP almost always originates in the ileum (90%) or jejunum (7%), and ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830050478
更新日期:1998-12-01 00:00:00
abstract::Colonic interposition is a treatment option in childhood when esophageal replacement (ER) is necessary. We reviewed 18 children who underwent ER by colon between 1984 and 1999. There were 5 with esophageal atresia and 13 with corrosive esophagitis; 15 had long-term follow-up (mean 38 months). Three procedures were per...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830000422
更新日期:2000-01-01 00:00:00
abstract::Congenital/infantile fibrosarcoma (IFS) is a relatively rare form of fibrosarcoma diagnosed at birth or during early years of life and that differs from its adult counterpart because of a more favorable behavior. IFS is also known as cellular congenital mesoblastic nephroma, when it affects the kidney and is often but...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-015-3670-7
更新日期:2015-04-01 00:00:00
abstract::Incarcerated inguinal hernias in infants are commonly encountered. Reduction with intravenous sedation using morphine and related drugs carries risks of apnoea and/or respiratory arrest, especially in small, ex-premature babies who have an increased incidence of incarceration and thus opiate use is best avoided. Cauda...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1534-2
更新日期:2005-09-01 00:00:00
abstract::To determine the long-term outcome of congenital cystic adenomatoid malformation (CCAM), the records of all patients with CCAM treated in three Hungarian paediatric surgical centers between 1977 and 1996 were reviewed. Patients were followed for up to 20 years following diagnosis and treatment. In 20 patients CCAM was...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050593
更新日期:1999-07-01 00:00:00
abstract::Manual reduction with the index finger (modified Hutchinson's maneuver) enabling simple and safe manual reduction of infantile intussusception is described. The procedure was used in four patients, two boys and two girls, ranging in age from 2 to 15 months, as greater than normal compression was necessary and/or seros...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s003830050301
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:The optimal treatment for pediatric Graves' disease (GD) is controversial. Antithyroid drugs are often used initially, but they are associated with a high failure rate. Therefore alternative therapies have become important. In the present study, we analyze our institution's experience regarding the safety and e...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-012-3095-5
更新日期:2012-06-01 00:00:00
abstract::Traditionally, open repair of esophageal atresia (EA) with tracheoesophageal fistula (TEF) required thoracotomy. Innovations in minimal access surgery have created a thoracoscopic technique resulting in violation of the pleural space. Most pediatric surgeons favor an extrapleural approach for open repair. We present a...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-005-1366-0
更新日期:2005-04-01 00:00:00
abstract::The occurrence of a coexisting congenital diaphragmatic hernia (CDH) and esophageal atresia (EA) with distal tracheoesophageal fistula is extremely rare and is considered highly lethal. Only 19 cases of CDH with EA have been reported in the world literature to date. This is a very challenging clinical problem, and the...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s003830050448
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:Voltage-gated potassium ion channels have long been implicated in gastrointestinal motility. Recent studies have highlighted the role of voltage-gated channel subfamily G member 3 (KCNG3) and 4 (KCNG4) genes in the electrical functioning of interstitial cells of Cajal and PDGFRα+ cells of the mouse colon. We de...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-018-4394-2
更新日期:2019-02-01 00:00:00
abstract::Our case report details the clinical course and management of a neonate with acute life-threatening respiratory distress presenting soon after birth. She needed intubation and ventilation. A pericardial cyst was diagnosed after a CT scan and 2D echo investigation. As a temporizing procedure the fluid was tapped and th...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-003-0970-0
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND/AIM:Esophageal dilatation, gastroesophageal reflux, and intestinal obstruction have been demonstrated in CDH survivors. Abnormal esophageal and intestinal innervations were recently found in rats and babies with this disease. Our aim was to further characterize these malformations in embryos and fetal rats e...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-010-2788-x
更新日期:2011-02-01 00:00:00
abstract::Foreign-body (FB) aspirations account for a reasonable percentage of respiratory emergencies in young children. Whereas 67% of aspirated FBs are of organic origin, metallic-ferromagnetic FBs are observed less frequently. We report the use of a wire with a magnetic tip fitting into the working channel of a rigid bronch...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/BF01076970
更新日期:1997-07-01 00:00:00
abstract::The successful use of a combination of "patch, drain, and wait" (PDW) and home total parenteral nutrition (TPN) in the management of a case of acute, catastrophic midgut volvulus in a 2-year-11-month-old boy with near-total ischemia/necrosis of his small intestine is reported. The PDW approach to the highly effective ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:
更新日期:1997-03-21 00:00:00
abstract::Congenital arteriovenous fistulas are a rare cause of neck mass in children, but should be considered in the differential diagnosis of paediatric patients presenting with pulsatile neck masses even when there is no history of trauma. Balloon embolisation is the treatment of choice because of the high risk of surgical ...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-011-2918-0
更新日期:2011-12-01 00:00:00
abstract::Cryptorchidism is a common paediatric complaint and is traditionally managed surgically by orchidopexy. We aimed to prospectively review the success of the Bianchi high scrotal incision technique for performing orchidopexy in boys with palpable non-descended testis. A total of 206 orchidopexies were performed in 85 pa...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-008-2149-1
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Sacrococcygeal teratoma (SCT) is the most common congenital neoplasm in neonates. We wished to assess the long-term functional outcome of children undergoing SCT resection. METHODS:Records of neonates diagnosed with SCT from two surgeons' practices, and operated on between 1970 and 2006, were retrospectively r...
journal_title:Pediatric surgery international
pub_type: 杂志文章
doi:10.1007/s00383-009-2322-1
更新日期:2009-03-01 00:00:00
abstract:AIM:To determine if follow-up by consultant pediatric surgeons (CPS) affects morbidity due to incarceration (INC) in children with indirect inguinal hernia (IH). METHODS:We educate parents so they can identify possible INC and advise them to attend our emergency department anytime for immediate review by on-call CPS. ...
journal_title:Pediatric surgery international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00383-011-3005-2
更新日期:2012-01-01 00:00:00
abstract::Umbilical hernias occur frequently in children but complications are very rare and thus surgery is not routinely indicated. In this literature review, we report 19 cases of spontaneous evisceration of abdominal contents through umbilical hernias. Precipitating causes included umbilical ulceration or sepsis, crying, re...
journal_title:Pediatric surgery international
pub_type: 杂志文章,评审
doi:10.1007/s00383-012-3076-8
更新日期:2012-05-01 00:00:00