New insights into the pathogenesis of Hirschsprung's associated enterocolitis.

Abstract:

:The management of Hirschsprung's disease (HD) has made dramatic strides over the last 20 years. Research into the embryological development and migration of ganglion cell has enabled a greater understanding of the pathogenesis of the disease. Coupled with new techniques in surgery, such as laparoscopy-assisted pull-through and the transanal pull-through, this knowledge has led to improved outcomes for children with HD. However, although our appreciation of Hirschsprung's associated enterocolitis and its aetiology has increased, there are continued references in the literature to a multitude of theories of pathogenesis. The purpose of this review is to delineate the theories and demonstrate the evidence supporting or otherwise contradicting each other.

journal_name

Pediatr Surg Int

authors

Murphy F,Puri P

doi

10.1007/s00383-005-1551-1

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

773-9

issue

10

eissn

0179-0358

issn

1437-9813

journal_volume

21

pub_type

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