Abstract：
:Lipiodol, a stable iodine addition product of fatty ethyl esters derived from poppyseed oil, has been used as a vehicle for targeted cytotoxic or radiotherapeutic treatment in adults with unresectable hepatocellular carcinoma and in a few children with advanced hepatoblastoma (HB). Prolonged retention of lipiodol by the cancer cells might enable more effective targeted therapy to advanced, multifocal, or metastatic HB. To investigate the uptake and cytotoxic efficacy of beta and Auger electron-emitting radioconjugates on HB cells, monolayers of HB (C3a, Hep Tow1) and normal human hepatocyte cell lines were exposed to lipiodol131 (L131), lipiodol125 (L125), or a cocktail of both isotopes. Uptake of radioactivity was assessed autoradiographically using phosphoimages and the cytotoxicity assessed by trypan blue exclusion and clonogenic assay. The uptake of the different radioconjugates was identical in both HB cell lines. The "cocktail" of both radioactive lipiodols caused the greatest cytotoxicity to HB C3a, and HepTow1. L125 alone had a similar level of uptake and cytotoxicity as L131. Radioactive iodine alone did not show any cytotoxicity on any of the liver cell lines in culture for up to 72 h. These experimental results provide support for a clinical strategy of combinations ("cocktails") of radioconjugates in targeted radiotherapy in patients with HB.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Towu E,Boxer G,Begent R,Zweit J,Spitz L,Hobbs K,Winslet Mdoi
10.1007/s003830100004subject
Has Abstractpub_date
2001-11-01 00:00:00pages
609-13issue
8eissn
0179-0358issn
1437-9813journal_volume
17pub_type
杂志文章abstract：:A review of 100 consecutive cases of congenital diaphragmatic hernia (CDH) treated at our institute focusing on the efficacy of protocolized management (PM) was conducted. Of the 100 cases, 14 who became symptomatic more than 24 h after birth, and seven with fatal anomalies (four cardiac and three chromosomal) were ex...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1759-8
更新日期：2006-11-01 00:00:00
abstract：:A neonate with a constellation of unusual congenital deformities associated with pulmonary agenesis is reported. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050603
更新日期：1999-07-01 00:00:00
abstract：:Endoscopic management is the accepted form of treatment for posterior urethral valves (PUV). The Nd:YAG laser has been in clinical use for many decades, but has been used only sporadically for ablating PUV. In this study, PUV were diagnosed by micturating cystourethrogram (MCU). In the 9-month period beginning March 1...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050018
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To compare the effect of home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis. METHODS:This was a randomized controlled trial of patients aged 4-17 with surgically treated perforated appendicitis from January 2011...
journal_title：Pediatric surgery international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00383-018-4343-0
更新日期：2018-12-01 00:00:00
abstract：:Retrocaval ureter is a relatively rare anomaly that usually manifests in the third or fourth decades. Symptoms are due to ureteric obstruction, either extrinsic by the abnormal inferior vena cava (IVC), or intrinsic ureteric hypoplasia. Surgery is needed for symptomatic cases and involves transection and relocation of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1038-x
更新日期：2004-02-01 00:00:00
abstract：:The management of a critical airway in infants and toddlers with congenital tracheal stenosis (CTS) continues to be an enormous challenge to the surgeon. Until recently, this condition often proved fatal. Improvements in surgical techniques, anesthetic management, and postoperative critical care have resulted in succe...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830050028
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:Rats are common intruders into human settlements. Apart from their role as disease vectors, they can also cause bite injuries. We describe the clinical course of a series of children with rat bites, and characterise the injures. METHODS:A retrospective review of hospital records of children admitted for rat bi...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-020-04799-6
更新日期：2021-01-21 00:00:00
abstract：PURPOSE:Intestinal perforation (IP) is a fatal complication in extremely low birth weight infants (ELBWI). We started administrating enteral miconazole (MCZ) to ELBWI in 2002. Since then, the incidence of IP has significantly decreased. The aim of this study was to elucidate the prophylactic effect of MCZ for the treat...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3946-6
更新日期：2016-10-01 00:00:00
abstract：:The first description diaphragmatic hernia appeared in 1575. In 1848, Bochdalek described congenital diaphragmatic hernia (CDH) occurring through a posterolateral defect. Successful surgical treatment of CDH in an infant was first performed in 1902, whereas the first neonate operated within 24 hours of life was report...
journal_title：Pediatric surgery international
pub_type： 历史文章,杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:The Thomsen-Friedenreich cryptantigen (TCA) is located on the surface of all red cells, but is concealed by a layer of neuraminic acid. When bacteria that produce neuraminidase disrupt this coating, the TCA can be exposed and activated. If blood products containing antibody to the TCA are subsequently administered, ha...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050488
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3833-6
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:Injury severity scoring tools allow systematic comparison of outcomes in trauma research and quality improvement by indexing an expected mortality risk for certain injuries. This study investigated the predictive value of the empirically derived ICD9-derived Injury Severity Score (ICISS) compared to expert c...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3900-7
更新日期：2016-07-01 00:00:00
abstract：:Accessory hepatic tissue, unlike accessory splenic and pancreatic tissue, is rare and has a limited and almost exclusively sub diaphragmatic distribution. Fewer than ten cases of intrathoracic ectopic liver have been reported so far in the literature. This paper reports a case that caused a diagnostic dilemma. ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830000520
更新日期：2001-07-01 00:00:00
abstract：:The use of a silo for temporary coverage of exposed viscera for newborns with gastroschisis has allowed gradual reduction of the externalized intestine into the abdominal cavity. However, there has not been an easy way to monitor blood perfusion to the intestine within the silo other than with visual examination. In a...
journal_title：Pediatric surgery international
pub_type： 临床试验,杂志文章
doi：10.1007/s00383-006-1726-4
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVES:Both aquaporin (AQP) 1 and the stem-cell factor/C-kit system seem to have a definite role in testis function, but very few studies have been reported in humans, especially in the paediatric age group. With the present study we wanted to investigate the expression of these proteins to better delineate their r...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-003-1125-z
更新日期：2004-04-01 00:00:00
abstract：:A 6-year-old girl presented with intractable constipation. On investigation, she was found to have an association of anorectal stenosis, anterior sacral defect, and anterior meningocoele (Currarino's triad). The meningocoele was excised and a Duhamel pull-through procedure performed after resection of a massively dist...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s003830050362
更新日期：1998-07-01 00:00:00
abstract：:An infant with a large-bowel obstruction due to Salmonella B enterocolitis is presented. The clinical and radiologic findings were suggestive of Hirschsprung's disease with total colonic aganglionosis. Due to further deterioration, an ileostomy was performed. Pathologic examination disclosed ganglia in the colon. At l...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003839900332
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:Since DX/HA was approved by the Food and Drug Administration in 2001 as an acceptable tissue-augmenting substance for subureteral injection, endoscopic treatment has become increasingly popular for treating vesicoureteral reflux (VUR). However, most paediatric urologists still continue to recommend ureteral rei...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2650-1
更新日期：2010-10-01 00:00:00
abstract：:We describe the case of a 4-year-old boy with a unilateral right-sided Wilms tumor with stromal predominance and teratoid features, which was localized to the kidney and hence, was completely resected. The pediatric surgeon and pathologist, both should be aware of this rare appearance of nephroblastoma so as to avoid ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-009-2333-y
更新日期：2009-03-01 00:00:00
abstract：:The management of Hirschsprung's disease (HD) has made dramatic strides over the last 20 years. Research into the embryological development and migration of ganglion cell has enabled a greater understanding of the pathogenesis of the disease. Coupled with new techniques in surgery, such as laparoscopy-assisted pull-th...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-005-1551-1
更新日期：2005-10-01 00:00:00
abstract：:Juvenile papillomatosis (JP) is a rare benign, proliferative breast tumor in children. We observed a 9-year-old girl with a large soft-tissue mass at the lower outer quadrant of the left breast. Ultrasonography showed an ill-defined, inhomogeneous mass with numerous small, hypoechoic areas. The tumor was completely ex...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830000462
更新日期：2001-03-01 00:00:00
abstract：PURPOSE:Determining the integrity of the pancreatic duct is important in high-grade pancreatic trauma to guide decision making for operative vs non-operative management. Computed tomography (CT) is generally an inadequate study for this purpose, and magnetic resonance cholangiopancreatography (MRCP) is sometimes obtain...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-018-4309-2
更新日期：2018-09-01 00:00:00
abstract：:For the assessment of germ-cell maturation of the seminiferous tubules, DNA flowcytometry is a rapid and sensitive method. Phosporus 31P magnetic resonance spectroscopy (MRS) is a non-invasive alternative that demonstrates the metabolic status of the testis, reflecting the type and relative proportion of germ cells in...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830100602
更新日期：2001-05-01 00:00:00
abstract：:Hepatogastric fistula secondary to amebic liver abscess is extremely rare. Only three pediatric cases have been reported in the English literature. Percutaneous drainage of abscess along with parenteral metronidazole can prevent the need for extensive surgical intervention. Timely intervention is usually followed by c...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1743-3
更新日期：2006-10-01 00:00:00
abstract：INTRODUCTION:The Morgagni hernia (MH) accounts for 3-4% of congenital diaphragmatic hernias. There is a paucity of data regarding this rare defect. The purpose of this study is to describe the characteristics of children with MH, surgical approaches for repair, and patient outcomes. METHODS:Pediatric patients (ages 0-...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-017-4078-3
更新日期：2017-07-01 00:00:00
abstract：:Sixty-seven patients with resected Wilms' tumour>1.0 kg are reported. Surgery in this group is difficult, may result in the sacrifice of adjacent structures, and frequently upstages the patient. Mortality is related to tumour burden. Whilst there is little agreement on the therapeutic implications of failure to respon...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1678-8
更新日期：2006-05-01 00:00:00
abstract：:Nonoperative management is acceptable treatment for minor pancreatic injuries. However, management of major pancreatic duct injury in children remains controversial. We present our experience in treating isolated pancreatic duct injury. We describe the cases of three male patients treated for complete pancreatic duct ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3570-2
更新日期：2014-09-01 00:00:00
abstract：:To determine the incidence of cystic fibrosis (CF) in neonates with intestinal obstruction (NIO) secondary to meconium ileus (MI), jejunoileal atresia (JA), meconium plug syndrome (MPS), volvulus (V), and meconium peritonitis (MP) and analyze the correlation of ultrasonographic (US) signs with CF in NIO with a prenata...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0781-8
更新日期：2003-04-01 00:00:00
abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas comprise a group of indolent B-cell non-Hodgkin lymphomas (NHL), which are rare in pediatric age. The clinical presentation of MALT lymphomas varies according to the location of the lymphoma. We report on a case of MALT lymphoma involving the appendix in a 6-year-old ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1957-z
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:Voltage-gated potassium ion channels have long been implicated in gastrointestinal motility. Recent studies have highlighted the role of voltage-gated channel subfamily G member 3 (KCNG3) and 4 (KCNG4) genes in the electrical functioning of interstitial cells of Cajal and PDGFRα+ cells of the mouse colon. We de...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4394-2
更新日期：2019-02-01 00:00:00
