Abstract:
:Resistance to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid dysgenesis. We report a case with both thyroid gland ectopy and resistance to thyroid hormone and, thus, a reduced capacity to produce and respond to thyroid hormone. The patient presented at 2 years of age with developmental delay, dysmorphic features, and elevation in both thyroxine and thyrotropin. We document her response to therapy with thyroxine, with particular regard to her growth and development. Persistent elevation of thyrotropin is commonly recognized during treatment of congenital hypothyroidism. Resistance to thyroid hormone may be an important additional diagnosis to consider in cases where thyrotropin remains persistently elevated.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Heather N,Hall K,Neas K,Potter H,Wiltshire Edoi
10.1542/peds.2011-0634subject
Has Abstractpub_date
2012-03-01 00:00:00pages
e817-20issue
3eissn
0031-4005issn
1098-4275pii
peds.2011-0634journal_volume
129pub_type
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