Growth and development in a child with resistance to thyroid hormone and ectopic thyroid gland.

Abstract:

:Resistance to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid dysgenesis. We report a case with both thyroid gland ectopy and resistance to thyroid hormone and, thus, a reduced capacity to produce and respond to thyroid hormone. The patient presented at 2 years of age with developmental delay, dysmorphic features, and elevation in both thyroxine and thyrotropin. We document her response to therapy with thyroxine, with particular regard to her growth and development. Persistent elevation of thyrotropin is commonly recognized during treatment of congenital hypothyroidism. Resistance to thyroid hormone may be an important additional diagnosis to consider in cases where thyrotropin remains persistently elevated.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Heather N,Hall K,Neas K,Potter H,Wiltshire E

doi

10.1542/peds.2011-0634

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

e817-20

issue

3

eissn

0031-4005

issn

1098-4275

pii

peds.2011-0634

journal_volume

129

pub_type

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