Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure.

Abstract:

:Serum concentrations of soluble interleukin 2 receptor (IL-2R) were measured in 65 hemodialysis patients and compared with serum levels of beta 2-microglobulin and tissue polypeptide antigen (TPA). Elevated IL-2R levels, found in 85% of examined patients, correlated with elevated TPA serum concentrations (p less than 0.05). Patients with high IL-2R levels were significantly younger (p less than 0.05) than patients with low levels. Primary renal disease and residual renal function had no significant influence on TPA or IL-2R serum concentrations. In 16 patients with carpal tunnel syndrome, increased serum concentrations of IL-2R (p less than 0.005) and TPA (p less than 0.001) were found. We conclude that a non-specific dialysis-induced activation of epithelial and lymphoid cells rather than a specific immune response could explain the concomitant elevation of IL-2R and TPA serum concentrations in hemodialyzed patients. Patients with pronounced cell turnover, reflected by elevated IL-2R and TPA levels, may show an increased susceptibility to dialysis-associated amyloidosis.

journal_name

Nephron

journal_title

Nephron

authors

Walz G,Kunzendorf U,Josimovic-Alasevic O,Preuschoff L,Schwarz A,Keller F,Asmus G,Offermann G,Diamantstein T,Distler A

doi

10.1159/000186125

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

157-61

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

56

pub_type

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