Abstract:
BACKGROUND:As efforts intensify to intervene early among those at risk for psychosis, examination of the relationship between presenting psychopathology and long-term functional outcome may guide treatment decision-making and offer a means to prevent or reduce chronic disability. METHODS:Data were collected through the Early Detection and Intervention for the Prevention of Psychosis Program (EDIPPP), a multisite national trial testing the efficacy of an early intervention for youth at risk of developing psychosis. Participants were followed prospectively and completed comprehensive evaluations at 6, 12, and 24 months, including the Structured Interview for Prodromal Syndromes (SIPS) and the Global Social and Role Functioning Scales. The present analyses included 327 participants and examined the relationships between baseline symptoms and longitudinal global social and role functioning using a linear mixed modeling approach. RESULTS:Higher baseline negative symptoms and deteriorated thought process predicted worse social and role functioning in the follow-up period. The effect of negative symptoms on social functioning, however, was moderated by positive symptoms, and the relationship between positive symptoms and social functioning changed over time. Baseline positive symptoms, distress, and level of symptom severity were not predictors of either social or role functioning. CONCLUSIONS:Baseline negative symptoms and thought disorder appear to predict functional outcome for up to two years among adolescents and young adults at risk for psychosis. Developing effective interventions to target these symptoms may be critical to promote functional recovery among those experiencing attenuated symptoms or a first episode of psychosis.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Burton CZ,Tso IF,Carrión RE,Niendam T,Adelsheim S,Auther AM,Cornblatt BA,Carter CS,Melton R,Sale TG,Taylor SF,McFarlane WRdoi
10.1016/j.schres.2019.07.048subject
Has Abstractpub_date
2019-10-01 00:00:00pages
157-162eissn
0920-9964issn
1573-2509pii
S0920-9964(19)30328-7journal_volume
212pub_type
临床试验,杂志文章,多中心研究abstract:OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.08.009
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00091-8
更新日期:2001-10-01 00:00:00
abstract::We tested the hypothesis that the expression of schizophrenic psychopathology is dependent on the stage of adolescent development. The study had a retrospective design, using high-quality case-note material of cases of schizophrenia at first admission. Patients with onset of illness between the age of 11 and 21 years ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)00020-9
更新日期:1995-01-01 00:00:00
abstract::Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(97)00068-6
更新日期:1997-10-30 00:00:00
abstract::Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.12.489
更新日期:2008-04-01 00:00:00
abstract::Individuals with psychotic illnesses are known to have a reduced fertility. It is unclear whether this is due to biological or social factors. Most fertility studies have been conducted in chronic schizophrenia, where confounders like medication and hospitalisation make this difficult to elicit. A less severe reductio...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.007
更新日期:2014-07-01 00:00:00
abstract::An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spon...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.06.028
更新日期:2011-11-01 00:00:00
abstract::Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudde...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.011
更新日期:2014-05-01 00:00:00
abstract::Previous research demonstrates that people with schizophrenia have abnormally 'restricted' visual scanpaths to face and facial expression stimuli, which appear to be diagnostically specific to schizophrenia [Schizophr. Res. 55 (2002) 159; Biol. Psychiatry 52 (2002) 338]. This study examined the familial transmission o...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00094-x
更新日期:2004-03-01 00:00:00
abstract::It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.12.854
更新日期:2006-04-01 00:00:00
abstract::Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2007.12.468
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2012.07.019
更新日期:2012-10-01 00:00:00
abstract::Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia prodrome [McGlashan et al., Schizophr. Res. (2003); Miller et al., Schizophr. Res. (2003)] performed at levels intermediate to population norms and data reported for ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.08.007
更新日期:2004-04-01 00:00:00
abstract::Numerous genetic and postmortem studies link N-methyl-d-aspartate receptor (NMDAR) dysfunction with schizophrenia, forming the basis of the popular glutamate hypothesis. Neuronal NMDAR abnormalities are consistently reported from both basic and clinical experiments, however, non-neuronal cells also contain NMDARs, and...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.10.004
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:We aimed to examine the association between illicit substance use and age at onset in psychotic disorders in an Australian cohort. METHODS:Retrospectively acquired information on substance use during the year prior to illness onset was collected from 1642 participants enrolled in the Australian National 201...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.003
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2009.03.004
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:People with schizophrenia have an increased risk of premature mortality compared to the general population. We aimed to quantify which types of causes of death contributed to the excess mortality, and to examine whether there has been an increase in the excess mortality among persons with schizophrenia in th...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.11.003
更新日期:2019-04-01 00:00:00
abstract::The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00201-8
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood. METHODS:We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic schizophrenia patient...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.021
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.03.016
更新日期:2019-07-01 00:00:00
abstract::Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00161-3
更新日期:1999-03-01 00:00:00
abstract:AIM:To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. METHODS:Individually linked health data in Denmark (2000-2012), Finland (2005-2014), Iceland (2004-2017), Norway (2005-2015), Sweden (2006-2015), Germany (2006-2015), Australia (New South Wales...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.03.048
更新日期:2020-06-01 00:00:00
abstract::Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors m...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2010.04.015
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been e...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.04.007
更新日期:2011-07-01 00:00:00
abstract::Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00130-4
更新日期:2001-03-30 00:00:00
abstract:BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including sui...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.02.001
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.06.027
更新日期:2015-10-01 00:00:00
abstract::Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.05.016
更新日期:2008-09-01 00:00:00
abstract::Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.12.007
更新日期:2012-03-01 00:00:00
abstract::In schizophrenia, clinical, familial and biological characteristics according to age at onset (AAO) suggest that AAO is a valid candidate symptom for genetic studies. However, none of the various thresholds used to define AAO subgroups in schizophrenia has been validated. We aim to define different AAO subtypes by adm...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.02.002
更新日期:2004-11-01 00:00:00