Abstract：
PURPOSE:To describe and evaluate the value of nutritional supplements in the management of age-related macular degeneration (AMD) through a review of the current literature. METHODS:An extensive literature search was performed, and key research articles exploring AREDS and AREDS-2 formulations, genetics, omega fatty acids, calcium and folic acid in high-risk women were reviewed. PubMed and Web of Science databases were used for generating articles to review. RESULTS:The AREDS and AREDS-2 trials, while difficult to validate, show support for antioxidant supplementation in reducing AMD progression in Caucasian populations. While genetic guided personalized medicine has been studied mainly with complement factor H and age-related maculopathy susceptibility 2 risk alleles, the data have not been reproducible. Women at a higher risk of cardiovascular disease may benefit from antioxidant therapies in preventing AMD. Omega 3 fatty acid supplementation has been widely supported through observational studies; however, randomized controlled trials have not shown benefit in disease progression. Calcium exposure has been linked to increased mechanisms in cell death and may be detrimental to older individuals with AMD. CONCLUSION:The data regarding nutritional supplements in preventing AMD progression are inconclusive, and therefore recommendations should be based on risk factors and demographic data.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Mukhtar S,Ambati BKdoi
10.1007/s10792-019-01140-6subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2975-2983issue
12eissn
0165-5701issn
1573-2630pii
10.1007/s10792-019-01140-6journal_volume
39pub_type
杂志文章,评审abstract：PURPOSE:To compare stage of visual field loss (VFL) and age at diagnosis between patients with different types of glaucoma with regard to glaucoma screening and driving ability. METHODS:In a cross-sectional study of 1988 consecutive patients with different types of glaucoma VFL at diagnosis and age at diagnosis were a...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0477-7
更新日期：2018-04-01 00:00:00
abstract：:This paper builds on results of a previous paper on the prevalence of trachomatous visual impairment as the foundation for assessing the global burden of trachomatous blindness and low vision: approximately 2.9 million cases of trachomatous blindness and 3.8 million low visioned corresponding to a global prevalence of...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00130921
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To evaluate the accuracy of an advanced manual corneal astigmatic marking method for toric intraocular lens (IOL) implantation. METHODS:From 52 patients, 52 eyes with cataracts and corneal astigmatism were included. The target axis of the toric IOL was marked with the new manual marking method preoperatively a...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01498-y
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:The aim of this prospective study is to verify, in terms of both early postoperative complications and intraocular pressure (IOP) outcomes, the performance of a scleral flap removable suture. MATERIALS AND METHODS:Sixty-six patients that underwent trabeculectomy were randomly divided into two groups: in t...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-008-9245-z
更新日期：2009-10-01 00:00:00
abstract：:After glaucoma filtering surgery subconjunctival injection of human recombinant tissue plasminogen activator may promote the function of glaucoma filter bleb and increase outflow facility. It can also increase postoperative complications, such as corneal damage. The aim of our research was to determine corneal endothe...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00156413
更新日期：1995-01-01 00:00:00
abstract：:We describe the first two cases of diffuse unilateral subacute neuroretinitis (DUSN) in the UK successfully treated with albendazole. Two patients are described who presented with unilateral reduction in vision, with clusters of yellow-white retinal lesions fading and reappearing in new locations of the fundus over a ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9358-z
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:The quality of cataract surgery delivered in sub-Saharan Africa (SSA) is a significant constraint to achieving the elimination of avoidable blindness. No published reports from routine SSA cataract services attain the WHO benchmarks for visual outcomes; poor outcomes (<6/60) often comprise 20% in published case...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0599-y
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy and safety of the bilateral simultaneous XEN (BISIXEN) surgery in open-angle glaucoma patients. METHODS:Retrospective analysis of a prospective data base conducted on uncontrolled glaucoma patients who underwent BISIXEN surgery. Primary endpoint measure was the incidence of sight-thr...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01640-w
更新日期：2021-01-02 00:00:00
abstract：:To investigate the efficacy of single-dose intravitreal dexamethasone implantation in the treatment of persistent diabetic macular edema (DME) unresponsive to 3 consecutive ranibizumab injections over a period of 6 months. Forty-one patients with a previous history of treatment for DME including at least three consecu...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-015-0155-6
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To investigate the diurnal fluctuations of macular vessel density (VD) in primary open-angle glaucoma (POAG) and healthy subjects using optical coherence tomography angiography. METHODS:A total of 22 POAG eyes and 15 healthy eyes were included in this study. Macular VD, intraocular pressure, and blood pressure...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01408-2
更新日期：2020-09-01 00:00:00
abstract：:A 71-year-old man presented with a large disciform scar in the right eye and hard (nodular) as well as soft (granular) drusen scattered throughout the posterior pole of the left eye. A large serous pigment epithelial detachment was evident in the drusen area of the left fundus. Six months later a tear of the retinal p...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00139344
更新日期：1987-06-01 00:00:00
abstract：PURPOSE:To investigate the changes in ocular higher-order aberrations (HOA) after trabeculectomy using mitomycin-C (MMC). METHODS:We retrospectively reviewed data for 63 eyes from 63 glaucoma patients who had undergone MMC augmented trabeculectomy. We measured intraocular pressure (IOP), refractive errors, anterior ch...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0802-1
更新日期：2019-01-01 00:00:00
abstract：:Clinical trials are often used to evaluate the efficacy of a given treatment. The results of clinical trials however do not always agree with a clinician's experience or intuition. The merits and demerits of Clinical Trials versus Intuition are discussed by using the laser photocoagulation trials of Proliferative Diab...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00159835
更新日期：1986-05-01 00:00:00
abstract：PURPOSE:To describe the incidence of, and risk factors associated with, diabetic retinopathy in diabetic persons assessed at a Saudi diabetes centre. METHODS:Five hundred and two patients with diabetes mellitus assessed by our service were studied. There were 174 patients (34.7%) with insulin-dependent diabetes mellit...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006240928938
更新日期：1998-01-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) is altered in several neurodegenerative diseases, the association between serum IGF-1 levels and glaucoma has not been evaluated. This study was designed to evaluate whether serum IGF-1 levels are different in patients with Pseudoexfoliation (PEX) with or without glaucoma. The stud...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0271-y
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:To compare the actual depth of the tunnel created with femtosecond laser for intracorneal ring segment (ICRS) implantation with the target depth in keratoconus patients. METHODS:In this mix design study, eligible keratoconus patients were identified through chart review. The inclusion criterion was a history o...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0595-2
更新日期：2018-08-01 00:00:00
abstract：:To evaluate the efficacy of 25-ga pars plana vitrectomy (PPV) and 25-ga PPV combined with phacoemulsification surgery for managing ciliary block (malignant) glaucoma. The medical records of 11 eyes, in nine consecutive patients with malignant glaucoma were retrospectively reviewed to determine the efficacy of 25-ga PP...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-9974-0
更新日期：2015-08-01 00:00:00
abstract：:Primary lacrimal sac melanoma is an extremely rare clinical entity with fewer than 25 cases reported in the literature. We present a well-documented case of lacrimal sac melanoma with anterior lacrimal crest infiltration and discuss the clinical, radiological and histopathological features along with surgical challeng...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9743-5
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:Ibopamine is used when performing provocative tests, thanks to its pharmacological property of increasing ocular pressure in eyes with outflow system impairment. This study summarizes the latest results that we have achieved with reference to its clinical-diagnostic use. METHODS:175 (250 eyes) POAG patients, 1...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00212962
更新日期：1996-01-01 00:00:00
abstract：:To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveiti...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0239-y
更新日期：2017-02-01 00:00:00
abstract：:Sensorineural hearing loss is the most common disease associated with systemic retinitis pigmentosa (RP). We have conducted an epidemiological study to assess the correlation of age at onset of visual symptoms and hearing loss associated with RP. Epidemiological data was derived from a questionnaire-based study of pat...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-005-2035-y
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:To evaluate the learning curve of non-penetrating glaucoma surgery (NPGS). METHODS:The study included 32 eyes of 27 patients' (20 male and 7 female) with medically uncontrolled glaucoma. Non-penetrating glaucoma surgeries performed by trainees under control of an experienced surgeon between 2005 and 2007 at ou...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0691-3
更新日期：2018-10-01 00:00:00
abstract：:The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00163552
更新日期：1990-10-01 00:00:00
abstract：:The purpose is to report a case of Candida interface infection after deep anterior lamellar keratoplasty (DALK). A 23-year-old female patient underwent DALK surgery in the left eye for keratoconus. Four weeks after the surgery, she presented with asymptomatic white-cream colored deposits at the graft-host interface. E...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-012-9545-1
更新日期：2012-08-01 00:00:00
abstract：:The purpose of this study is to investigate whether subconjunctival and/or intrastromal Bevacizumab injections could help to prevent graft failure in high-risk keratoplasties. Twenty seven eyes of 27 patients, affected by high immune rejection risk and corneal neovascularization, were involved in this prospective inte...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-014-9938-4
更新日期：2015-04-01 00:00:00
abstract：:The purpose of this study was to investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography instruments, namely: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0306-4
更新日期：2017-06-01 00:00:00
abstract：:In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00202776
更新日期：1987-02-01 00:00:00
abstract：PURPOSE:To evaluate rotational stability and visual and refractive outcomes of supplementary toric IOLs (Sulcoflex Toric 653T, Rayner Intraocular Lenses Ltd) for residual astigmatic refractive error in pseudophakic eyes. METHODS:A retrospective interventional case series was conducted in a single surgeon practice. Cha...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-1027-7
更新日期：2019-09-01 00:00:00
abstract：:We report the immunopathology and histopathology of a patient with Terson syndrome. The design was an observational case-report. Histopathology and immunohistochemical staining for endoglin (CD105) of an eye from a patient with subarachnoid haemorrhage and Terson syndrome was performed. Immunohistology revealed high p...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-010-9343-6
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:To determine whether gene polymorphisms which are associated with age-related macular degeneration (AMD) influence treatments' response and specifically the antioxidant supplementation in dry AMD patients, as well as the anti-vascular endothelial growth factor (anti-VEGF) therapy in neovascular AMD patients. M...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-019-01274-7
更新日期：2020-04-01 00:00:00
