Abstract:
:To investigate the efficacy of single-dose intravitreal dexamethasone implantation in the treatment of persistent diabetic macular edema (DME) unresponsive to 3 consecutive ranibizumab injections over a period of 6 months. Forty-one patients with a previous history of treatment for DME including at least three consecutive intravitreal ranibizumab injections were enrolled in this retrospective study. Main outcome measures were change in best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure from baseline to 6th month. At the baseline, the mean CMT was 572.4 ± 123.1 μm which improved to 264.2 ± 114.4, 317.7 ± 141.7, 410.6 ± 169.1, and 382.8 ± 181.5 μm at the 1st, 3rd, 5th, and 6th month, respectively (p < 0.05). The preoperative mean BCVA was 0.85 ± 0.54 logMAR units which improved to 0.76 ± 0.5 (p = 0.08), 0.69 ± 0.4 (p = 0.02), 0.74 ± 0.4 (p = 0.284), and 0.72 ± 0.3 (p = 0.489) logMAR units at the 1st, 3rd, 5th, and 6th months, respectively. Additional injections were required for 13 (31 %) eyes at 3rd month and 14 (34 %) eyes at 5th month due to recurrence of macular edema. Intravitreal dexamethasone implantation caused a significant improvement of BCVA and reduction of CMT in the patients with persistent DME that were unresponsive to 3 consecutive ranibizumab injections. However, retreatment before 6 months in the majority of the patients was needed despite the beneficial effects after the index procedure.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Arıkan Yorgun M,Toklu Y,Mutlu M,Uysal BS,Çakmak HBdoi
10.1007/s10792-015-0155-6subject
Has Abstractpub_date
2016-08-01 00:00:00pages
531-9issue
4eissn
0165-5701issn
1573-2630pii
10.1007/s10792-015-0155-6journal_volume
36pub_type
杂志文章abstract:PURPOSE:To examine the retinal layers' changes and alterations in retinal microvasculature in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV). METHODS:Participants in this study were 103 patients with RRD, 85 macula off and 18 macula on, who were treated with PPV and gas ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01521-2
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To present the long-term results of therapeutic keratoplasty for microbial keratitis in moderate to advanced phases. METHODS:The medical records of 44 patients who underwent therapeutic keratoplasty for microbial keratitis at the ophthalmology clinic of a training and research hospital between June 2012 and Ma...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01538-7
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:This study investigated postoperative visual acuity and corneal higher-order aberrations following EX-PRESS or trabeculectomy. METHODS:Out of 56 eyes of 56 patients analyzed, 30 eyes were treated using trabeculectomy, while 26 eyes were treated with EX-PRESS. Visual acuity and corneal higher-order aberrations ...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1007/s10792-017-0685-1
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To evaluate the changes on optical coherence tomography angiography (OCTA) in macula-off rhegmatogenous retinal detachments (RRD) treated with pars plana vitrectomy (PPV) and silicone oil (SO) 5000-cSt tamponade. MATERIALS AND METHOD:Forty-five eyes with macula-off RRD treated with PPV and SO tamponade were en...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01516-z
更新日期:2020-12-01 00:00:00
abstract::To look for a correlation between or the effect of anisometropia amblyopia on retrobulbar blood flow parameters. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the ophthalmic artery (OA), central retinal artery (CRA), and temporal posterior ciliary artery (tPCA) were measured with color Doppler imagi...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9572-y
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To compare capillaries perfusion in macular areas at different layers and peripapillary region in radial peripapillary capillaries (RPC) between healthy subjects and subjects with obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence tomography angiography (OCTA). METHODS:Totally 16 ey...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01518-x
更新日期:2020-12-01 00:00:00
abstract::Acute and invasive fungal infections are usually seen in immunocompromised and debilitated patients. We report a young immunocompetent 28-year-old Indian male who presented with unilateral endogenous endophthalmitis in the left eye and was managed with pars plana vitreous surgery. The polymerase chain reaction from th...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-008-9235-1
更新日期:2009-08-01 00:00:00
abstract::We report an unusual case of disseminated cysticercosis having simultaneous intraocular and extraocular involvement. This 21-year-old male presented with recent loss of vision in one eye and history of a single seizure. Examination revealed intravitreal cysticercosis with exudative retinal detachment. Computed tomogra...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-005-8248-2
更新日期:2005-02-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00127638
更新日期:1983-02-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章,评审
doi:10.1007/s10792-017-0740-y
更新日期:2018-12-01 00:00:00
abstract:UNLABELLED:The purpose of this study is to evaluate the effect of trephination with free scleral auto-implant plug exposed to Mitomycin-C out of the eye, in surgical treatment of primary open-angle glaucoma (POAG), in comparison with efficacy of trabeculectomy with MMC (32 eyes with POAG of patients, younger than 55 ye...
journal_title:International ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00212952
更新日期:1996-01-01 00:00:00
abstract::In the original publication, first line of methods under the Abstract section was published incorrectly. ...
journal_title:International ophthalmology
pub_type: 已发布勘误
doi:10.1007/s10792-020-01327-2
更新日期:2020-04-01 00:00:00
abstract::Oestrus ovis or 'sheep botfly' causes common ophthalmomyiasis in warm climates. It is a self-limited infestation with symptoms such as foreign body sensation and/or tearing. The larvae can be observed in the conjunctiva and should be extracted with forceps. The development of larvae beyond the first stage does not occ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-012-9644-z
更新日期:2013-04-01 00:00:00
abstract::Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America. Although a large-scale vector control program has been highly successful in limiting transmission of infection in West Africa, there has not been a satisfactory form of treatment available for those already inf...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00136735
更新日期:1987-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01355-y
更新日期:2020-07-01 00:00:00
abstract::We report on a patient with an overhanging bleb several years following trabeculectomy surgery with mitomycin C. ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-011-9477-1
更新日期:2011-10-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-0910-6
更新日期:2019-05-01 00:00:00
abstract::The aim of this study is to determine the incidence of cystoid macular edema (CME) following repositioning and McCannel iris-suturing of dislocated intraocular lenses. This study is conducted in an urban private practice. A retrospective chart review was performed on consecutive patients who presented with posteriorly...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-014-9964-2
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To evaluate the long-term safety and efficacy of infliximab therapy for refractory uveitis associated with Behçet's disease (BD). METHODS:We prospectively enrolled six patients who failed to respond to conventional immunosuppressive treatment. Infliximab infusions (5 mg/kg) were administered at weeks 0, 2, 6, ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-006-9006-9
更新日期:2005-06-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01604-0
更新日期:2020-10-22 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00175263
更新日期:1996-01-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To investigate the changes in the anterior chamber volume (ACV) with swept-source optical coherence tomography (SS-OCT) after cataract surgery and the factors that influence these ACV changes. METHODS:This was a prospective cohort study. Fifty-one patients who underwent cataract surgery were enrolled. Their AC...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1012-1
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To describe a case of scattered toxicity of indocyanine green on the outer retina and retinal pigment epithelium (RPE) after indocyanine green (ICG) assisted membrane peeling for macular pucker. METHODS:A 61-year-old woman was examined by slit-lamp biomicroscopy, fluorescein angiography (FA), indocyanine green...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-007-9112-3
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To explore whether retrobulbar administration of nerve growth factor (NGF) can restore visual function of streptozotocin-induced diabetes rats. METHODS:A high-sucrose/high-fat diet and single injection of streptozotocin (STZ) were used in modeling diabetes. During week 13-15 after STZ injection, diabetic rats ...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-020-01537-8
更新日期:2020-12-01 00:00:00
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journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/BF00163559
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the use of Optical Coherence Tomography (OCT) in the diagnosis of macular edema (ME) in diabetic patients in comparison to indirect ophthalmoscopy (IO) and, in addition, to study the characteristics of these patients. METHODS:165 patients were randomly selected to join the study in 1998. Ophthal...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1023/b:inte.0000006784.52885.e9
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate rotational stability and visual and refractive outcomes of supplementary toric IOLs (Sulcoflex Toric 653T, Rayner Intraocular Lenses Ltd) for residual astigmatic refractive error in pseudophakic eyes. METHODS:A retrospective interventional case series was conducted in a single surgeon practice. Cha...
journal_title:International ophthalmology
pub_type: 杂志文章
doi:10.1007/s10792-018-1027-7
更新日期:2019-09-01 00:00:00