Abstract:
UNLABELLED:Statin therapy is the cornerstone of anti-atherosclerotic treatment, and it considered obligatory in the secondary prevention of atherosclerotic diseases. Rosuvastatin is well-known and efficacious lipid-lowering agent. Generic drugs are more frequently used instead of its ancestors. Generic rosuvastatin forms have been approved recently to the Central European market, but their safety and efficacy have not been previously examined in cerebrovascular patient populations. PATIENTS AND METHODS:109 patients with documented ischaemic cerebrovascular events were included in our study. 20 mg generic rosuvastatin significantly decreased total cholesterol (5.47 vs. 3.88 mmol/l, p<0.01), low-density lipoprotein (3.16 vs. 1.84 mmol/l, p<0.01) and trigliceride levels (1.77 vs. 1.33 mmol/l, p<0.05, and there was a non-significant high-density lipoprotein increasing tendency (1.27 vs. 1.36 mmol/l, p = 0.08). There was also a significant decrease in high-sensitive C-reactive protein levels (3.73 vs. 2.82 mg/l, p<0.05). Overall, 30% decrease in total cholesterol, 42% decrease in low-density lipoprotein, 25% decrease in trigliceride and high-sensitive C-reactive protein and 9% increase in high-density lipoprotein levels were observed. CONCLUSIONS:The generic rosuvastatin studied by the authors proved to be safe and efficacious lipid-lowering agent. Based on these short term results, in daily practice, generic rosuvastatin treatment seems to be cost-effective for the treatment of patients with ischemic cerebrovascular disease.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Szapáry L,Fehér Gdoi
10.1556/OH.2012.29390subject
Has Abstractpub_date
2012-06-03 00:00:00pages
857-60issue
22eissn
0030-6002issn
1788-6120pii
D6JJ4TPGJ27J4589journal_volume
153pub_type
杂志文章相关文献
ORVOSI HETILAP文献大全abstract::The advances in molecular genetic methods has lead to the discovery of the genetic alterations that underlie the etiology of most diseases previously held to be idiopathic. Targeted genetic examination of a pediatric male patient showing a normal intellect, an extended area of skin hypopigmentation, and suffering from...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31404
更新日期:2019-05-01 00:00:00
abstract::L. J. Thénard and J. L. Gay-Lussac discovered hydrogen peroxide in 1818. Later, Thénard noticed that animal and plant tissues decompose hydrogen peroxide. The substance which is responsible for this reaction was named as catalase by O. Loew in 1900. The catalase enzyme was regarded as a diagnostic and a tumour marker ...
journal_title:Orvosi hetilap
pub_type: 历史文章,杂志文章
doi:10.1556/650.2018.31096
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Neoadjuvant therapy has improved outcomes for patients with locally advanced rectal cancer. AIM AUTHORS: We studied the degree of histopathological regression after radiotherapy regimens commonly used in their clinical practice, and its effect on the pathology of by clinically founded T3-T4 rectal cancer. P...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-22 00:00:00
abstract::The authors present their experience with the endoscopic kidney stone removal in pediatric patients. They treated 55 children under 14 with this method. If the stone was large they used ultrasonic disintegration. On the basis of their own experience and the technical literature they assert that most of the pediatric k...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1989-08-27 00:00:00
abstract::The endothelium is a major regulator of vascular tone, releasing vasoconstrictive (endothelin, cyclooxigenase-dependent factors, including prostanoids and oxygen free radicals) and vasodilating (endothelium--derived nitric oxid, endothelium--derived hyperpolarizing factor) mediators. These biologically active substanc...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2001-08-05 00:00:00
abstract:INTRODUCTION:The authors report about the efficacy of inserted tympanostomy tube in children with serous otitis media. AIM:The aim of the authors was to assess the status of eardrum, the function of Eustachian tube and hearing level 10 years after the use of tympanostomy tube. METHOD:Patients filled out a questionnai...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2015.30291
更新日期:2015-11-15 00:00:00
abstract::Inherited errors of metabolism are rare genetic disorders characterized by diverse clinical and biochemical phenotypes. The complexity of signs and symptoms often presents a challenge for both clinicians and laboratory specialists. In many cases, prevention of permanent neurological symptoms or death in patients prese...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2017.30899
更新日期:2017-12-01 00:00:00
abstract::In the report on 35 CT-guided fine needle transthoracic biopsies the authors show the relevance of invasive radiological methods in tumor diagnostics. The results are compared with those published in the literature. CT-guided transthoracic biopsy is of crucial importance in final diagnosis of certain thoracic diseases...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-06-27 00:00:00
abstract:INTRODUCTION:The high prevalence of morbidity among female physicians in Hungary is well documented, however, little is known about the prevalence of that in certain age groups. AIMS:To assess the prevalence of somatic and psychiatric morbidity in two age cohorts (Cohort 1: age 24-43 and Cohort 2: age 44-76) of female...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2013.29521
更新日期:2013-01-06 00:00:00
abstract::The author report on the first implantations of gliding prosthesis performed without sticking in Hungary. Gliding prostheses of Hungarian product were used. Thirty operations have been carried out so far. The technique and results will be discussed in a later publication on the basis of higher number of cases. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1989-07-16 00:00:00
abstract::Developments in the fields of laser technology and application have significantly broadened its clinical use over the past two decades. As lasers became more smaller, more reliable and less expensive, dermatology will benefit new laser-based therapeutic and diagnostic methods. Relevant laser systems and their clinical...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-04-30 00:00:00
abstract::Two cases of intramural hematoma arising in the duodenum and the stomach are reported. Both patients were male, aged 40 and 58 years, and suffered from chronic pancreatitis. Hematoma of the duodenal wall may have resulted from the acute exacerbation of the chronic pancreatitis in the first patient. As to the second ca...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1998-12-06 00:00:00
abstract::The authors observed ischaemic damages in jejunal loops used for esophageal reconstruction with full or partial regeneration. In addition to the case reports, they discuss the cause, the mechanism, the possible prevention and correction of this rare complication. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1997-11-23 00:00:00
abstract::Generalized (systemic) secondary amyloidosis was a post mortem finding recorded in 28 patients (25.2%) by amyloid specific Congored staining according to Romhányi, from 111 randomized autopsy cases with rheumatoid arthritis. Amyloidosis was present most frequently in the gastro-intestinal tract, the heart, kidney, thy...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-11-21 00:00:00
abstract::The rarely described gastric micropneumatosis is caused by accumulating air in the mucus membrane. It may associate mainly with Helicobacter pylori positive atrophic gastritis or with pneumatosis due to gas producing bacteria or non-infectious causes. In our case the disorder was diagnosed in a 69 years old patient, t...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2007.27959
更新日期:2007-04-29 00:00:00
abstract::There is a great interest to determine the physiological role of "free" nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiolog...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2016.30621
更新日期:2016-11-01 00:00:00
abstract::Improvement of muscle mass and force which got depleted by inactivity or pathological processes is one of the aims and also a prerequisite of a rehabilitative intervention. Metabolically active larger and stronger muscles diminish the cardiovascular risk, permit the aerobic preventive and rehabilitative activities and...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-09-18 00:00:00
abstract::Due to the rapidly increasing number of end-stage renal disease patients and the high costs of their treatment, all the aspects of kidney disease that may significantly affect clinical outcome (quality of life mortality) deserve increasing attention. It has been established and accepted that in addition to clinical/so...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2009.28586
更新日期:2009-03-29 00:00:00
abstract:UNLABELLED:The authors summarize the present knowledge on arrhythmogenic right ventricular cardiomyopathy/dysplasia. Limited data are available about natural history of asymptomatic patients with arrhythmogenic right ventricle cardiomyopathy/dysplasia, who have a ventricular tachycardia during exercise test. A 25-year ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2010.28995
更新日期:2010-12-26 00:00:00
abstract:UNLABELLED:In daily practice mycotic infections of the CNS have become more and more frequent. The main causes are the wide-ranging use of corticosteroids, immunosuppressive, cytostatic drugs and antibiotics, the spreading of AIDS, the increasing number of surviving immature newborns. To illustrate the diagnostic diffi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2009.28657
更新日期:2009-07-19 00:00:00
abstract::Primary liver cancer is the fifth most common cancer worldwide. Hepatocellular carcinoma accounts for 85-90% of primary liver cancers. Distribution of hepatocellular carcinoma shows variations among geographic regions and ethnic groups. Males have higher liver cancer rates than females. Hepatocellular carcinoma occurs...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2008.28313
更新日期:2008-03-23 00:00:00
abstract::The authors discuss the role of nuclear medicine techniques in the modern diagnostics of breast cancer, including the methods currently used in Hungary and the future possibilities. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2012.29256
更新日期:2012-01-08 00:00:00
abstract::A total of 171 pleural needle biopsies were carried out in 123 patients with pleural effusion. The sensitivity of the method proved to be 51% for malignant diseases and 75% for tuberculotic pleurisy, respectively. Performing biopsy simultaneously with the cytological examination of the pleural fluid, malignancy was pr...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-11-14 00:00:00
abstract:INTRODUCTION:Transfer is a planned movement of patients and their medical records from one provider to another. Only a few data are available from real life in inflammatory bowel disease patients in this topic. AIM:Our aim was to retrospectively evaluate the results of the transfer of our patients without longitudinal...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2018.31198
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The risk of colorectal carcinoma development is elevated in chronic, longstanding ulcerative colitis. The changes of such regenerative and immortalizing pathways caused by the inflammatory process that are proved to be carcinogenic in other human tissues have not been fully and uniformly described. Aim of th...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-09-24 00:00:00
abstract::The authors made diagnosis of valvar pulmonary stenosis in a 1-day old neonate. The severe stenosis was treated by means of pulmonary balloon valvuloplasty at the age of 4 days. The initial suprasystemic pressure in the right ventricle decreased to normal after the procedure. Transluminal balloon valvuloplasty is an e...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-04-07 00:00:00
abstract:UNLABELLED:Monitoring the pharmacokinetic parameters of different anticancer drugs is necessary because they might have several side effects. AIM:Pharmacokinetic and toxicity evaluation of high-dose methotrexate treatments in children with acute lymphoblastic leukemia. PATIENTS AND METHODS:43 children (28 boys, 15 gi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2011.29143
更新日期:2011-10-02 00:00:00
abstract::Anxiety frequently develops in human life and it is usually useful for the organism. Anxiety helps accomodation to the social environment, however, it may be harmful when it is intensive and long-lasting. It can also cause psychosomatic diseases. Anxiety may present itself as mild or moderate stress, psychosomatic dis...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2014.29925
更新日期:2014-06-01 00:00:00
abstract::The paper gives an introduction to the basis and quality control of a relatively new imaging method. First the different kinds of SPECT instruments, and then the aspects of diagnostic application are described. Details are given on examinations of the central nervous system, the abdomen, the hearth and the skeletal sy...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-19 00:00:00
abstract::In Szabolcs-Szatmár county between January 1 1983 and December 31, 1987, 465 new cases of adult malignant haematologic diseases were registered by authors. The authors present the yearly distribution of cases, and analyse the main types and characteristics of the disease entity. According to their data the epidemiolog...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1990-02-25 00:00:00