[Insulin-like growth factor receptor, hepatocyte-derived growth factor receptor and telomerase expression in ulcerative colitis].

Abstract:

BACKGROUND:The risk of colorectal carcinoma development is elevated in chronic, longstanding ulcerative colitis. The changes of such regenerative and immortalizing pathways caused by the inflammatory process that are proved to be carcinogenic in other human tissues have not been fully and uniformly described. Aim of the study was to describe the expression alterations of regenerative signal receptors and cell aging inhibitory systems within colonic crypts considering the histological activity of the disease. MATERIALS AND METHODS:I-type insulin-like growth factor receptor (IGF1R), hepatocyte derived growth factor receptor (HGFR), telomerase reverse transcriptase (TERT) and telomerase associated protein (TP-1) expression were evaluated immunohistochemically on formalin fixed paraffin embedded biopsy specimen from 10 mild, 10 moderate, and 10 severe active inflammation of ulcerative colitis and from 10 normal colonic tissue. RESULTS:In mild inflammation all observed parameter showed significantly elevated protein expression in protein level compared to normal (p <0.005). In moderately active inflammation only IGF1R expression was significantly higher compared to normal and to mild inflammation (p <0.005). There were no regenerative signal expression alteration in severe inflammation compared to normal, and epithelial telomerase expression was not detectable in these cases. CONCLUSION:The expression of regenerative signal receptors and immortalizing factors is elevated in mildly (and moderately) inflamed ulcerative colitis. This phenomenon let the genetically defected epithelial cells to pathologically survive and proliferate, so thus favours the development of tumors.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Sipos F,Molnár B,Zágoni T,Miheller P,Tulassay Z

subject

Has Abstract

pub_date

2006-09-24 00:00:00

pages

1835-41

issue

38

eissn

0030-6002

issn

1788-6120

journal_volume

147

pub_type

杂志文章
  • [Therapy of mental states at high risk for psychosis: preliminary results from Hungary].

    abstract:INTRODUCTION:Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. AIMS:To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. METHODS:Fifty-two persons who fulfilled t...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kéri S,Kelemen O,Janka Z

    更新日期:2006-02-05 00:00:00

  • [What influences the rate of complications during phase II. residential cardiac rehabilitation after coronary events?].

    abstract:AIM:The authors sought to investigate the occurrence of complications and adverse events among patients participating in phase II. Residential cardiac rehabilitation program after coronary event (myocardial infarction, transluminal coronary angioplasty or coronary artery bypass graft operation) and determine the factor...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Simon A,Berényi I,Tiringer I,Veress G

    更新日期:2006-04-16 00:00:00

  • [Laparoscopic surgery in tubal pregnancy].

    abstract::The author accounts about twenty patients operated on tubal pregnancy established on ultrasonic and laparoscopy. He refers the history of the methods of surgical interventions and the difficulties of the diagnosis nowadays. He makes known the technics of the laparoscopical operation and the operated patients' postoper...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Tóth Ferenc Z

    更新日期:1993-01-24 00:00:00

  • [Papillary renal cell carcinoma].

    abstract::The authors present a case of a papillary type renal cell carcinoma. The tumor is mostly discovered accidentally; a histopathological evaluation is indispensable for an exact diagnosis. Because of a better prognosis, differentiation of this tumor type from the classic variant of renal cell carcinoma is necessary, howe...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Glasz T,Rusz A,Doros A,Schaff Z

    更新日期:2001-08-12 00:00:00

  • [Activity of neutral endopeptidase in serum of patients with primary biliary cirrhosis].

    abstract::Neutral endopeptidase (neprilysin; EC 3.4.24.11) is present in the brush border membrane, for example in the bile ducts. We investigated serum neprilysin activity and its correlation with cholestatic markers in patients with primary biliary cirrhosis. Sera of 39 patients with primary biliary cirrhosis (37 females, 2 m...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Horvát-Karajz K,Csepregi A,Nemesánszky E,Tulassay Z,Selmeci L,Szalay F

    更新日期:2000-04-30 00:00:00

  • [Skin as an immune system].

    abstract::Skin consists of three structurally and functionally distinct compartments containing resident and nonresident cells. These cells cooperative with humoral pathway of immune system in defence of healthy skin. Resident and nonresident cells are able to initiate inflammatory or immune processes of skin, although intersti...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Hunyadi J,Szabó I,Simon M Jr

    更新日期:1994-12-11 00:00:00

  • [The role of gastrointestinal ulcer in the differential diagnosis of low back pain].

    abstract::The authors call on attention for the differential diagnostical problems of low back pain and the importance of the Head zones by describing one case. A patient was admitted to hospital with severe symptoms of low back pain. In her previous medical history there were musculo-skeletal problems for many years in additio...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Schneider F,Böröcz I,Lakatos T

    更新日期:2001-12-16 00:00:00

  • [Morbidity, demography and life style of Hungarian medical doctors 25 years after graduation].

    abstract:UNLABELLED:The health status and social circumstances of medical professionals have been studied worldwide. However, there are only a few published studies pertaining to these topics in the countries of the former Eastern block. The present paper aimed at charting the state of health, the medical career path and some s...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2009.28566

    authors: Rurik I,Kalabay L

    更新日期:2009-03-22 00:00:00

  • [Mainz pouch II, a modified method of ureterosigmoidostomy].

    abstract::The authors applied a new method, the low pressure ureterosigmoidostomy, namely the Mainz pouch II. The essence of the operation was a reverse "U" shape opening of the sigma, detubularization, then suturing together, so a diverticulum like cavity was created, and the ureters were implanted here. The detubularization b...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Pajor L,Romics I,Kelemen Z,Frang D

    更新日期:1996-03-31 00:00:00

  • [A case of numerous foreign bodies found in the esophagus and the right main bronchus].

    abstract::The authors report about the elimination of foreign bodies fixed in the oesophagus and aspirated into the right main bronchus. They discuss the diagnostic work and the ways of its elimination. They emphasize the importance of cooperation between the endoscopist and the surgeon. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Vass G,Réfi M,Juhász M

    更新日期:1992-07-12 00:00:00

  • [History of the therapy of pernicious anemia].

    abstract::Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of liver against anaemia in clinical studies. ...

    journal_title:Orvosi hetilap

    pub_type: 历史文章,杂志文章

    doi:10.1556/OH.2013.29743

    authors: Jeney A

    更新日期:2013-11-03 00:00:00

  • [Public health control of hyperhomocysteinemia and its consequences].

    abstract::The etiological role of hyperhomocysteinemia in the origin of neural-tube defects was proved, therefore a mandatory flour folic acid fortification program was introduced in the USA since January 1, 1998. In Hungary one kind of breads was fortified with folic acid, vitamin B12 and vitamin B6. The Hungarian randomised c...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Czeizel E,Kalina A

    更新日期:2003-10-05 00:00:00

  • [Epilepsy surgery in childhood: theory and practice].

    abstract::1-1.5% of the Hungarian child population has epilepsy, and around 20% of them produces seizures in spite of modern antiepileptic drugs. A part of the pharmaco-resistant children may benefit from surgical removal of the epileptogenic focus. Presurgical evaluation has been developed a lot since the progress of neuroimag...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Fogarasi A,Neuwirth M,Gyorsok Z,Czirják S,Vajda J,Bognár L

    更新日期:2003-11-30 00:00:00

  • [Vitamin D metabolism and osteoporosis in systemic sclerosis].

    abstract::In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2017.30816

    authors: Szamosi S,Horváth Á,Szekanecz Z,Szűcs G

    更新日期:2017-08-01 00:00:00

  • [Restricted antibody diversity after bone marrow transplantation--homogeneous immunoglobulins].

    abstract::After bone marrow transplantation, a prolonged dysregulation of humoral immunity, including restricted electrophoretic heterogeneity of serum immunoglobulins and the appearance of homogeneous immunoglobulin components, can be observed. The current study was undertaken to characterize further and define the posttranspl...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Puskás E,Hajdu M,Barta A,Sipos A,Uher F,Pálóczi K

    更新日期:2001-02-11 00:00:00

  • [Anesthesiologic and intensive care requirements in liver transplantation].

    abstract::The complex anaesthesia and intensive care of liver transplantation require special instruments beside expert's knowledge. We monitorize the haemodynamics invasively during the operation and immediately afterward. In the later period of intensive care we prefer the noninvasive haemodynamic monitoring techniques. The t...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Bobek I,Járay J,Perner F

    更新日期:1996-10-20 00:00:00

  • [Cirrhosis and cholelithiasis. Laparoscopic or open cholecystectomy?].

    abstract:UNLABELLED:Recently laparoscopic cholecystectomy has become the standard operation in case of cholelithiasis. The range of contraindications has decreased, a previous abdominal surgery, a severe cholecystitis or gravidity are not self-evident contraindications any more. The advantages and benefits of laparoscopic inter...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2008.28450

    authors: Déry L,Galambos Z,Kupcsulik P,Lukovich P

    更新日期:2008-11-09 00:00:00

  • [Incidence of type 2 diabetes among oral cancer patients in Hungary].

    abstract:INTRODUCTION:Data proves that Hungary has a leading role in the statistics of oral cancer and patients living with type 2 diabetes. AIM:Our aim was to understand the statistical correlation between oral cancer and metabolic disorder (diabetes mellitus and impaired fasting glucose) due to the valuable data from the Sem...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31076

    authors: Bányai D,Végh D,Vaszilkó M,Végh Á,Ács L,Rózsa N,Hermann P,Németh Z,Ujpál M

    更新日期:2018-05-01 00:00:00

  • [Isolation of free DNA from archived serum samples suitable for molecular genetic studies].

    abstract:INTRODUCTION:Collected and archived serum samples could be important sources for genetic studies, once DNA suitable for molecular genetic studies could be obtained from them. METHODS:DNA was isolated from 54 archived sera samples, collected previously from the participants of a Hungarian allergy study, with commercial...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Nagy B,Tarja L,Bán Z,Andrásofszky Z,Papp G,Lázár L,Nékám K,Papp Z,Réthy LA

    更新日期:2004-11-21 00:00:00

  • [Effectivity of the Nissen fundoplication and the influencing factors of the success. Results at the Medical Centre of Pécs depending on the indications and symptoms].

    abstract:INTRODUCTION:Gastroesophageal reflux disease is one of the most common gastrointestinal diseases in developed countries. Besides the conservative modalities, surgery plays an increasing role in the treatment of the disease. AIM:Our aim was to investigate and compare the surgical and 6-month follow-up data of patients ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31056

    authors: Varjú P,Horváth ÖP,Papp A,Gede N,Czimmer J

    更新日期:2018-06-01 00:00:00

  • [Study of skeletal features in congenital hypodontia].

    abstract:INTRODUCTION:The incidence of congenital hypodontia is increasing in daily practice. Early diagnosis of this dental disorder and the associated skeletal malocclusions is crucial for successful and stable final rehabilitation. AIM:Comparison of cephalometric findings of patients with hypodontia of 1-4 teeth with the me...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2019.31288

    authors: Mártha IK,Cămărășan A,Pop SI,Kerekes Máthé B

    更新日期:2019-02-01 00:00:00

  • [Obstructive sleep apnea--its clinical significance, and the role of general practitioners in its treatment and care].

    abstract::It is has been widely studied and proved that obstructive sleep apnea is a risk factor for cardiovascular diseases, especially hypertension, myocardial infarction and stroke. It is also important to be aware that, due to sleep apnea, hypersomnia increases the risk of accidents and the prevalence of neuropsychiatric co...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2010.28948

    authors: Torzsa P,Kalabay L,Adám A,Novák M,Mucsi I

    更新日期:2010-10-17 00:00:00

  • [Importance of secondary conditions in rehabilitation medicine].

    abstract::The author interprets disability on the basis of the "International Classification of Functioning, Disability and Health (ICF)". In this review the applied method is a purpose oriented, restricted survey of continuously increasing articles published during the last two decades. Definition and interpretation of seconda...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2012.29504

    authors: Kullmann L

    更新日期:2012-12-09 00:00:00

  • [Effectiveness of pentoxifylline and of bio-electromagnetic therapy in lower limb obliterative arterial disease].

    abstract:INTRODUCTION:There are limited therapeutic options to improve microcirculation. AIM:The question of the study was to investigate any potential beneficial effect of bio-electro-magnetic-regulation therapy on microcirculation in patients suffering from obliterative peripheral arterial disease including the circulation o...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2013.29693

    authors: Bernát SI

    更新日期:2013-10-20 00:00:00

  • [Cost/benefit calculations of meticillin-resistant Staphylococcus aureus screening methods and their practical importance].

    abstract::Nosocomial infections are the main cause of extra charges in health care and they relate to patient safety, as well. About 30 percent of healthcare-associated infections can be prevented effectively with infection control and adequate screening methods. Currently, meticillin-resistant Staphylococcus aureus is the main...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2010.28869

    authors: Knausz M,Kaproncai G,Rozgonyi F

    更新日期:2010-05-30 00:00:00

  • [Unilateral Sertoli-cell androblastoma in the ovary of a young woman].

    abstract::The authors present a case of a Sertoli-cell type androblastoma of the ovary. The tumor is mainly seen in young women and is mostly discovered through hormonal dysfunctions linked to it. Histopathological evaluation is indispensable for an exact diagnosis. Because of its rarity, there is little experience with the tum...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Istók R,Langmár Z,Szabó I,Glasz T,Székely E,Bánhidy F,Acs N,Paulin F,Magyar E,Schaff Z

    更新日期:2004-03-28 00:00:00

  • [Neuropeptide-containing nerve fibers in the gallbladder].

    abstract::With the use of different antisera and Avidin-Biotin-Peroxidase technique, several immunopositive nerve fibers were observed in the wall of the gallbladder of the cat. A large amount of neuropeptide Y, substance P, somatostatin, vasoactive intestinal polypeptide immunoreactive nerve fibers were found in all layers. Th...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Fehér E,Fodor M,Szentpály O,Koncz E,Fehér J

    更新日期:1993-01-24 00:00:00

  • [The importance of "free" nucleic acids in the non-invasive diagnostics].

    abstract::There is a great interest to determine the physiological role of "free" nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiolog...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2016.30621

    authors: Nagy B,Csanádi Z,Póka R

    更新日期:2016-11-01 00:00:00

  • [Drug therapy of gastroesophageal reflux (a prospective controlled clinical trial)].

    abstract::One year follow up(1.5, 3, 6, 12 months) study was established to examine the role of several classes of drugs in the treatment of reflux disease in 40 patients on the basis of objective control parameters (pH-metry, endoscopy, histology). The therapy was initiated, respectively, the different stage of severity (Savar...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:

    authors: Wittmann T,Rosztóczy A,Fehér A,Jármay K,Oláh T,Szendrényi V,Kiss I

    更新日期:1998-05-03 00:00:00

  • [Tyrosine kinase inhibitor STI571: new possibility in the treatment of chronic myeloid leukemia].

    abstract::Chronic myeloid leukemia shown to be associated with the Ph translocation,--characterised as a t(9;22)--, joins the bcr and abl genes and leads to expression of chimeric BCR-ABL protein with enhanced tyrosine kinase (TK) activity. This increased TK activity leads to malignant transformation by interference with the co...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Molnár L,Losonczy H

    更新日期:2002-10-20 00:00:00