Abstract:
:Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of liver against anaemia in clinical studies. After oral administration of liver (45-50 g per day) for 45 patients with anaemia perniciosa improvement of the hematological status was demonstrated. Consequently, for proving the therapeutic value of liver therapy Whipple, Minot and Murphy received Nobel price in 1934. The isolation of the antianemic factor from the liver has been succeeded in 1948 and designated as vitamin B12. At the same time Lucy Wills applied yeast for the treatment of pregnant women with anemia related to undernourishment. The conclusions of this study inspired the discovery of folate. The detailed investigation of the mode of action of vitamin B12 and folate enriched our knowledge in the area of pathophysiology and extended the clinical application of these two drugs. :A kivéreztetett kísérleti állatok vérregenerációját Whipple a nyers máj, Jeney és Jobling pedig a máj vizes kivonatának adagolásával tudta fokozni. A májetetés terápiás hatékonyságát Minot és Murphy 45, anaemia perniciosás betegen 1926-ban igazolták. Whipple, Minot és Murphy a májterápia sikeres alkalmazásáért 1934-ben Nobel-díjban részesült. A B12-vitaminnak elnevezett hatóanyagot 1948-ban sikerült májból kivonni. Lucy Wills ugyanezen években alultáplált, terhes asszonyok anaemiáját kedvezően tudta befolyásolni élesztőkivonattal, ami a folsav felfedezéséhez vezetett. Mindkét gyógyszer hatásmódjának tanulmányozása jelentősen gazdagította patofiziológiai ismereteinket, továbbá újabb terápiás alkalmazásokat tárt fel. Orv. Hetil., 2013, 154, 1754–1758.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Jeney Adoi
10.1556/OH.2013.29743subject
Has Abstractpub_date
2013-11-03 00:00:00pages
1754-8issue
44eissn
0030-6002issn
1788-6120pii
387J6XL5JN145X57journal_volume
154pub_type
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