[Skin as an immune system].

Abstract:

:Skin consists of three structurally and functionally distinct compartments containing resident and nonresident cells. These cells cooperative with humoral pathway of immune system in defence of healthy skin. Resident and nonresident cells are able to initiate inflammatory or immune processes of skin, although interstitial reactions (activation by bacteria, immunoglobulin or complement) also take place in such processes. In normal conditions nonresident cells can migrate through vascular endothel, however, PMN granulocytes and B lymphocytes cannot. Resident and nonresident cells of skin are capable of exerting a wide range of immunomodulatory effects, among them keratinocytes are of distinguished significance producing arachidon metabolites and IL-1 as well. Activated skin cells might induce chemotactic migration of distinct white blood cells normally absent or only a few cells being present in healthy skin. Cell migration into the interstitial space of skin is mediated by adhesion molecules expressed on cell surface of migrating cells, vascular endothel cells and on keratinocytes. Composition and density of adhesion molecules vary by type of stimuli, therefore various cytokines might induce distinct reactions mediated by certain population of cells. In addition, initiation and progress of immune- or inflammatory reactions are determined by the involved cell-populations as well. Normal regulation provides appropriate control and termination of the reaction, however, uncontrolled regulation results in development of pathological state.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Hunyadi J,Szabó I,Simon M Jr

subject

Has Abstract

pub_date

1994-12-11 00:00:00

pages

2749-54

issue

50

eissn

0030-6002

issn

1788-6120

journal_volume

135

pub_type

杂志文章
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    authors: Ruszty L,Hidas I,Iványi J,Dudás M,Molnár S

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    authors: Balázs M,Baksa J,Faller J

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  • [Dietary and pharmacological aspects of eosinophilic esophagitis].

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    doi:

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  • [Possibilities of the use of lymphoscintigraphy in head and neck surgery: introductory studies].

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    doi:

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  • [Subacute cutaneous lupus erythematosus based on a study of 15 cases].

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    doi:

    authors: Marschalkó M,Dobozy E,Daróczy J,Gyimesi E,Horváth A

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  • [Acute dissection of the ascending aorta diagnosed by two-dimensional echocardiography].

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    doi:

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  • [Otosclerosis. 2nd part. Diagnosis].

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  • [Reconstruction of the mandible using a vascularized graft from the iliac bone].

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    doi:

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  • [Budapest physicians practicing alternative medicine (based on a September 1991 survey)].

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  • [Cerebral blood flow studied by SPECT and transcranial Doppler sonography in subarachnoid hemorrhage].

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    doi:

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    doi:

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    doi:

    authors: Baksa J

    更新日期:1991-02-24 00:00:00

  • [Biological markers reflecting peripheral effects of thyroid hormones in autonomous thyroid adenoma].

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    pub_type: 杂志文章

    doi:

    authors: Földes J,Németh J,Bános C,Tarján G,Büki B

    更新日期:1991-09-08 00:00:00

  • [Bacterial biofilms and medical practice].

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    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kétyi I

    更新日期:1989-11-12 00:00:00

  • [Intraoperative evaluation of the function of the saphenous vein as coronary graft, visualized by myocardial contrast echocardiography].

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    doi:

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  • [Bicentennial of catalase research, 1818-2018].

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