Abstract：
INTRODUCTION:Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. AIMS:To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. METHODS:Fifty-two persons who fulfilled the PACE (Personal Assessment and Crisis Evaluation) criteria of ultra-high risk for psychosis participated in the study. Low-dose antipsychotic treatment (haloperidol or risperidone, 0.5-2 mg/day) was provided for 6 months together with psychoeducation and supportive psychotherapy. Participants were assessed at baseline, 6 months, and 12 months. Antidepressive therapy was provided as needed. RESULTS:Forty-two persons completed the study from whom 3 (7.1%) developed schizophrenia during the 6-month treatment period. New psychotic episodes were not observed during the 6-month follow-up period. Side effects were mild and transient, appearing in the first 4 weeks of treatment. The participants were satisfied with the treatment. CONCLUSIONS:Given that without a specific treatment, 30-60% of persons with ultra-high risk develop frank psychosis, low-dose antipsychotic treatment seems to be effective in the prevention or delay of psychosis.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Kéri S,Kelemen O,Janka Zsubject
Has Abstractpub_date
2006-02-05 00:00:00pages
201-4issue
5eissn
0030-6002issn
1788-6120journal_volume
147pub_type
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