[Laboratory evaluation of immunological dysfunctions in primary immunodeficiency diseases].

Abstract:

:In primary immunodeficiencies, the malfunction of the immune system is caused by genetic alterations. The physician proposes the most probable diagnosis based on symptoms, clinical signs, the family history and the results of the pathogen identification. To confirm this clinical suspicion, it is essential that the immunological malfunction be tested using in vitro diagnostic procedures. This paper summarizes the screening, confirmatory and disease-specific laboratory methods capable of testing the antibody response, the T cells, the phagocytic function, the complement system and other components of the innate immune system. The genetic tests necessary to make the final diagnosis are beyond the scope of this publication. Orv Hetil. 2018; 159(49): 2087-2094. :Absztrakt: A primer immunhiányos betegségekben az immunrendszer hibás működését genetikai eltérés okozza. A kezelőorvos a klinikai tünetek, jelek, a családi anamnézis és a kórokozó-kimutatás eredményei alapján veti fel a lehetséges diagnózisokat. A gyanú igazolásához nagy segítséget ad, ha az érintett immunológiai funkció in vitro diagnosztikai módszerekkel tesztelhető. A közlemény az antitestválasz, a T-sejtek, a phagocytafunkció, a komplementszisztéma és a veleszületett immunrendszer egyéb elemeinek vizsgálatára alkalmas szűrő, megerősítő és betegségspecifikus laboratóriumi módszereket foglalja össze, nem taglalva a végső diagnózist megadó genetikai teszteket. Orv Hetil. 2018; 159(49): 2087–2094.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Nagy G

doi

10.1556/650.2018.31261

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2087-2094

issue

49

eissn

0030-6002

issn

1788-6120

journal_volume

159

pub_type

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