[Pharmacokinetic analysis of high-dose methotrexate treatments in children with hematologic malignancies].

Abstract:

UNLABELLED:Monitoring the pharmacokinetic parameters of different anticancer drugs is necessary because they might have several side effects. AIM:Pharmacokinetic and toxicity evaluation of high-dose methotrexate treatments in children with acute lymphoblastic leukemia. PATIENTS AND METHODS:43 children (28 boys, 15 girls, mean age: 7.03 years) in 147 cases were treated with 5 g/m2/24h MTX according to ALL-BFM 1995 and 2002 protocols. Methotrexate and 7-hydroxi-methotrexate levels were measured with high pressure liquid chromatography at 24, 36, 48 hours. Authors registered the development of hepatotoxicity, nephrotoxicity, grade III/IV oral mucositis. RESULTS:Therapeutic methotrexate serum concentrations (30-100µmol/l) were achieved in 72.5% of the cases. Repeated treatments resulted similar serum levels. Hepatotoxicity and hypoproteinemia occurred in 17% and in 48.9% of the cases. There was significant correlation between serum 7-hydroxi-methotrexate and creatinine levels (p<0.05). CONCLUSION:5 g/m2 methotrexate resulted reliable therapeutic serum levels with mild and reversible toxicity. 7-hydroxi-methotexate measurements might be more useful than methotrexate levels to detect toxicity.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Csordás K,Eipel O,Hegyi M,Csóka M,Pap E,Kovács G

doi

10.1556/OH.2011.29143

subject

Has Abstract

pub_date

2011-10-02 00:00:00

pages

1609-17

issue

40

eissn

0030-6002

issn

1788-6120

pii

V4428546W1141775

journal_volume

152

pub_type

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