Abstract:
:Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis of the enzyme is regulated by interleukin 1 and tumor necrosis factor a. These inflammatory cytokines play a role in diabetes and vascular disease. An increase in vascular mechanical forces, that play a role in atherogenesis, also increase the synthesis of EL. There is expression of EL in endothelial cells, macrophages and muscle cells of atherosclerotic lesions of coronary arteries of humans. This evidence leads to the suspicion that EL plays a role in atherogenesis. There are also higher plasma levels of EL in subjects with type 2 diabetes, who are especially susceptible to the development of vascular lesions. Therefore the inhibition of EL could play an important role in HDL metabolism and could be a new therapeutic strategy for the prevention of atherosclerosis.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Pierart Z C,Serrano L Vdoi
10.4067/S0034-98872012000300015subject
Has Abstractpub_date
2012-03-01 00:00:00pages
373-8issue
3eissn
0034-9887issn
0717-6163pii
S0034-98872012000300015journal_volume
140pub_type
杂志文章,评审abstract:BACKGROUND:There is close association between maltreatment during pregnancy and child abuse after birth. AIM:To compare anthropometric growth and use of health services of children whose mothers suffered maltreatment with children coming from families without domestic violence. SUBJECTS AND METHODS:A longitudinal stu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::On 17-19 May 2006, the World Health Organization (WHO) and the March of Dimes Birth Defects Foundation held a meeting in Geneva: The Management of Birth Defects and Haemoglobin Disorders. Meeting participants included 18 experts from developing and industrialized countries, including the author and nine staff from WHO...
journal_title:Revista medica de Chile
pub_type:
doi:10.4067/s0034-98872007000600018
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Psychological problems are a frequent cause of consultation in primary care outpatient clinics. AIM:To report the results for Santiago de Chile of the World Health Organisation multicentric collaborative study on Psychological Symptoms in General Health Care. PATIENTS AND METHODS:The results of 1453 patien...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-01 00:00:00
abstract::We report a 35 years old female presenting with a right wrist pain. Physical examination was normal but, on a hand X ray examination, multiple dense para-articular bone foci were observed. Studying the rest of the skeleton, similar alterations were found in pelvis, knees, ankles, feet, shoulders and elbows. Osteopoiki...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Psychiatric disorders that appear during childhood or adolescence should be a public health priority. AIM:To report the results of a national representative survey in the Latin American region examining the prevalence of DSM-IV psychiatric disorders in children and adolescents. MATERIAL AND METHODS:Subject...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000400005
更新日期:2012-04-01 00:00:00
abstract::In the context of a festschrift to commemorate the 125th anniversary of the Revista Médica de Chile, "radiography" of the journal has been depicted using several scientometric indicators. Among the mainstream journals in the category of Medicine, General & Internal and taking into account the wide editorial coverage a...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::To be successful, modern medical acts require the participation of several professionals and assistants and, as such, there has been a steady trend from individual medicine to the collective practice of the profession. This format raises issues in determining when a medical professional or other practitioner is liable...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000500016
更新日期:2011-05-01 00:00:00
abstract::The model of epidemiological transition proposed by Omram explains the changes in disease patterns in communities. In societies with a high level of development this model has been complemented with the study of the post transition process. In this context, the emergence of allergic diseases, asthma and subsequently, ...
journal_title:Revista medica de Chile
pub_type: 社论
doi:10.4067/s0034-98872006000600001
更新日期:2006-06-01 00:00:00
abstract::One hundred and twenty consecutive patients with liver cirrhosis and ascites were prospectively studied in order to analyze the frequency, clinical and bacteriological features, recurrence, and prognosis of spontaneous bacterial peritonitis (SBP). Two variants of SBP were defined: culture positive SBP and culture nega...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::We report a 74-year-old male with liver metastases from a neuroendocrine tumor (NET) of unknown origin. Conventional imaging studies with ultrasound, computed tomography colonoscopy and Positron emission tomography-computed tomography (PET/CT) with 18Fluor odeoxyglucose did not identify the site of origin of the prima...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000400012
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Community-acquired pneumonia (CAP) that requires hospitalization, is a common and serious disease. A permanent assessment in specialized centers, to define therapeutic guidelines according to local epidemiological factors, is mandatory. AIM:To study the etiology of CAP requiring hospital admission. PATIENT...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Cerebral vasodilators (CVD) account for 1.6% of the annual expenditure on drugs in Chile. Two kinds are typified: what we have called orthodox CVD and calcium-channel blockers. They have two main uses in neurology: firstly, in acute ischaemic stroke where orthodox CVD (buflomedil, codergocrine mesylate, and nicergolin...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract::ANCA (anti-neutrophil cytoplasmic antibodies) associated vasculitis or AAV are a group of diseases with predominant inflammation of small vessels and the presence of detectable ANCA in serum. Due to these common features, it is considered that AAV share pathogenic mechanisms. Consequently, a similar therapeutic approa...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013000600011
更新日期:2013-06-01 00:00:00
abstract::We performed real time echotomographic studies in 203 patients with a clinical diagnosis of obstructive jaundice. All patients were operated on and a diagnosis of choledocholithiasis was established in 125. The same diagnosis had been made by echo in 69 of them for a 63% sensitivity rate. The specificity was 92% and t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::An increased life expectancy is associated to a nation's progress. Life expectancy at birth is 78 years in developed countries, 72 in Latin America, 70 in China, 63 in Eastern Europe and 51 in Africa. Chile is the Latin American country with the higher increment in life expectancy, reaching 75 years at birth, during t...
journal_title:Revista medica de Chile
pub_type: 社论
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Self-efficacy refers to people's expectations about personal resources available for goal achievement. Higher self-efficacy expectations are correlated with higher academic performance. AIM:To analyze the psychometric properties of the Academic Behavior Self-Efficacy Scale (ABSES) and to describe Self-effic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700914
更新日期:2019-07-01 00:00:00
abstract::An analysis of the interaction of evolutionary factors such as migration, mutation, selection random drift, and consanguinity upon the genome of Easter islanders is attempted. As many primitive populations, the Easter islanders genome has at least 2/3 of genetic loci in an isogenic state. The HLA system is reduced; ot...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:In 1992, a consensus conference defined the terms systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock. Since then, numerous reports have validated the prognostic usefulness of these operative definitions. AIM:To evaluate if sepsis severity criteria, as defined by the Conse...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::In the last decades there has been an important decrease in infant mobidity and mortality, but these achievements are not equally distributed across the whole population. Children are one of the most susceptible groups due to their unique vulnerabilities to environmental factors. Unhealthy environments, indoor polluti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000100016
更新日期:2009-01-01 00:00:00
abstract::We studied 501 prostitutes from the northern and eastern areas of Santiago in november and december, 1987. HIV infection was studied by the HIV antibody and also by HIV antigen. At that time no positive reactors were found. Prostitutes from the northern area were older, of a lower socioeconomic background and less pro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Chronic inflammatory demyelinating polyneuropathy is a heterogeneous disease characterized by symmetrical motor and sensitive alterations, absence of tendon reflexes and increased cerebrospinal fluid protein levels. We report 6 patients with the disease, (three males) aged 41 to 70 years old. Four had the classical pr...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in t...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract::The association of hyperthyroxinemia and euthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 micrograms/dl (N 6.1-12.5), a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::Glucocorticoids (cortisol in humans) are essential for numerous biological functions. Among critically ill patients, therapy with cortisol has gained strength in recent years, but clinical results have been mixed. A series of events, that may explain the diversity of clinical responses, occur from the synthesis of cor...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872017000200011
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Despite the low frequency of thyroid nodules (TN) in children, one of every four is malignant. Fine-needle aspiration cytology (FNAC) has a high accuracy detecting thyroid cancer. AIM:To evaluate the performance of FNAC in TN in Chilean children to detect thyroid cancer. PATIENTS AND METHODS:The pathologic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000300007
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Medical care of HIV infected and AIDS patients may represent an important economical burden for public hospitals. AIM:To assess direct and indirect costs of medical care for HIV infected and AIDS patients in public hospitals of the Metropolitan Region of Chile. MATERIAL AND METHODS:Between August 1994 and ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Oral cancer in Chile corresponds approximately to 1.6% of all cancer cases. There are few studies about oral epithelial dysplasia and oral squamous cell carcinoma in the Chilean population. AIM:To determine the frequency of hyperkeratosis, mild, moderate and severe oral epithelial dysplasia, in situ carcino...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000200004
更新日期:2016-02-01 00:00:00
abstract::We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant ge...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::Papillary serous carcinoma with low malignant potential, similar to those described in the ovary, can also originate in the peritoneum. Characteristically they show peritoneal spread without involvement of the ovary and, if present, it corresponds to a superficial implant similar to those seen in the rest of the perit...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::This article reports verbatim the National Development Plan for 1978-1983, issued by the Office of the President of the Chilean Republic, and by the Office of National Planning. The document states that an increase in population would be desirable; however, action toward such goal is to be taken by individual couples...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00