Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

abstract：:To study the significance of dynamic evolution of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and intestinal fatty acid-binding protein (I-FABP) levels in neonatal necrotizing enterocolitis (NEC). A total of 45 NEC child patients, 45 non-NEC child patients and 45 healthy newborns were enrolled. After t...

journal_title：Experimental and therapeutic medicine

authors： Li Z,Sheng L

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to validate the feasibility of modified frontolateral partial laryngectomy without tracheotomy using animal experiments. The glottic area before and after surgery of 6 excised canine larynges and 10 canine larynges in vivo were compared to observe whether the glottic area following modified f...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Dong P,Sun Z,Xie J

更新日期：2013-02-01 00:00:00

abstract：:Pulmonary embolism may escape prompt diagnosis since clinical symptoms and signs are nonspecific. The occurrence of syncope as the sole initial symptom in a previously healthy patient with no predisposing factors to embolism and no hemodynamic instability is extremely rare, which may have been a factor in the delayed ...

journal_title：Experimental and therapeutic medicine

authors： Jiang AG,Lu HY

更新日期：2013-05-01 00:00:00

abstract：:The incidence of oral squamous cell carcinoma (OSCC) is continuously increasing while its survival rate has not notably improved. There is a pressing need for improved understanding of the genetic regulation of OSCC tumorigenesis and progression. In this study, the function of miR-448 in the regulation of OSCC growth ...

journal_title：Experimental and therapeutic medicine

authors： Shen L,Liu L,Ge L,Xie L,Liu S,Sang L,Zhan T,Li H

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to summarize the clinical characteristics and experiences of misdiagnoses of cerebral venous thrombosis (CVT). A total of 18 patients with CVT who received treatment between September 2009 and August 2011 were enrolled. Of the patients, 13 were females and 5 were males with an average age of 39...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Sun X,Liu H

更新日期：2012-11-01 00:00:00

abstract：:Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. Afte...

journal_title：Experimental and therapeutic medicine

authors： Liu J,DU C,Wang Y,Yu Z

更新日期：2015-02-01 00:00:00

abstract：:The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combinati...

journal_title：Experimental and therapeutic medicine

authors： Wu J,Wang W,Shao Q,Xiao G,Cheng J,Yuan Y,Zhang M

更新日期：2014-09-01 00:00:00

abstract：:Glucocorticoids are a class of steroid hormones commonly used for the treatment of hematological malignancies due to their ability to induce apoptosis in lymphoid cells. An understanding of the critical steps in glucocorticoid-induced apoptosis is required to identify sources of drug resistance. Previously, we found t...

journal_title：Experimental and therapeutic medicine

authors： Tome ME,Lee K,Jaramillo MC,Briehl MM

更新日期：2012-02-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is closely associated with organ injury. The aim of the present study was to investigate the change of ALDH2 expression in a rat model of sepsis-induced acute renal injury, and to observe the effect of ALDH2 inhibition on the kidney. A model of sepsis syndrome was establi...

journal_title：Experimental and therapeutic medicine

authors： Hu JF,Wang HX,Li HH,Hu J,Yu Y,Gao Q

更新日期：2017-09-01 00:00:00

abstract：:The present study aimed to investigate the effect of triptolide (TL) on ulcerative colitis (UC) and explore the potential association between the therapeutic effects of TL and IL-1β expression using a 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS)-induced mouse model to simulate human UC. A total of 70 BALB/c female...

journal_title：Experimental and therapeutic medicine

authors： Zhang H,Gong C,Qu L,Ding X,Cao W,Chen H,Zhang B,Zhou G

更新日期：2016-09-01 00:00:00

abstract：:The current study mainly evaluated the plasma level of microRNA (miR)-136 in knee osteoarthritis (KOA) patients and determined if miR-136 could be used as a potential biomarker to screen KOA patients from healthy controls. It was demonstrated that plasma miR-136 was significantly decreased in the plasma of KOA patient...

journal_title：Experimental and therapeutic medicine

authors： Wan L,Zhao Q,Niu G,Xiang T,Ding C,Wang S

更新日期：2018-10-01 00:00:00

abstract：:Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance in human OVC remains unclear. Th...

journal_title：Experimental and therapeutic medicine

authors： Niu YC,Tong J,Shi XF,Zhang T

更新日期：2020-08-01 00:00:00

abstract：:Erythropoietin (EPO), a glycoprotein originally known for its important role in the stimulation of erythropoiesis, has recently been shown to have significant protective effects in animal models of kidney and intestinal ischemia-reperfusion injury (IRI). However, the mechanism underlying these protective effects remai...

journal_title：Experimental and therapeutic medicine

authors： Rong R,Xijun X

更新日期：2015-08-01 00:00:00

abstract：:Tartrate-resistant acid phosphatase 5b (TRACP 5b) has been used as a biomarker of bone resorption and cancer metastasis. TRACP 5b has also been suggested to be a reliable marker of osteoclast number. In this study, the correlation of TRACP 5b level and osteoclast-like cell number was investigated in RAW 264.7 cells tr...

journal_title：Experimental and therapeutic medicine

authors： Lv Y,Wang G,Xu W,Tao P,Lv X,Wang Y

更新日期：2015-01-01 00:00:00

abstract：:Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TMZ to improve diasto...

journal_title：Experimental and therapeutic medicine

authors： Zhao Y,Li S,Quan E,Zhang H,Wu Y,Luo Y,Peng L,Wang J,Zhu J,Liu J

更新日期：2019-08-01 00:00:00

abstract：:The present study determined the expression of microRNA (miR)-663 in hypertrophic scar (HS) tissues and investigate the regulatory mechanisms of miR-663 in HS. A total of 51 patients diagnosed with HS between December 2013 and February 2016 were included in the present study. HS tissues (experimental group) and HS-adj...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Zhao T,Xie X,Yu D,Wu L,Yu W,Sun W

更新日期：2018-08-01 00:00:00

abstract：:The programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1), are also involved in regulation of the PD-1/PD-L1 signaling pathway. In the present study, the expression l...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Xiao Y,Su M,Zhang R,Ding J,Hao X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00

abstract：:Kawasaki disease (KD) is the leading cause of acquired heart disease in pediatric patients in developed countries. Coronary artery aneurysms and myocardial infarction may occur if the disease remains untreated. An estimated 10-20% of KD patients do not respond to intravenous gamma globulin (IVIG), and thus, alternativ...

journal_title：Experimental and therapeutic medicine

authors： Dai N,Zhao C,Kong Q,Li D,Cai Z,Wang M

更新日期：2019-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2017.4943.]. ...

journal_title：Experimental and therapeutic medicine

authors： Li S,Xu G,Gao F,Bi J,Huo R

更新日期：2018-10-01 00:00:00

abstract：:Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). This study was carried out to investigate the correlation between the expression or activity of P-gp i...

journal_title：Experimental and therapeutic medicine

authors： Zhang B,Shi Y,Lei TC

更新日期：2012-10-01 00:00:00

abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...

journal_title：Experimental and therapeutic medicine

authors： Cai MM,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:MicroRNAs (miRs), a class of small non-coding RNAs, function as key regulators in gene expression through binding to the 3'-untranslated region (UTR) of their target mRNA, which further leads to translational repression or mRNA degradation. Recently, miR-138 has been found to have a tumor suppressive role in a variety...

journal_title：Experimental and therapeutic medicine

authors： Yuan Z,Mo H,Mo L,He J,Wu Z,Lin X

更新日期：2017-06-01 00:00:00

abstract：:FRMD7 mutations are associated with X-linked idiopathic congenital nystagmus (ICN); however, the underlying mechanisms whereby mutations of FRMD7 lead to ICN remain unclear. In a previous study, the first FRMD7 splice variant (FRMD7-S) was cloned and identified, and FRMD7-S was hypothesized to play a significant role ...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Pu J,Zhang B

更新日期：2014-10-01 00:00:00

abstract：:It is firmly established that smoking is a risk factor of cardiovascular disease, stroke and peripheral vascular disease. Although smoking alters the hemostatic process, the influence of smoking on human platelet activation remains controversial. For patients undergoing surgery, cessation of smoking prior to the proce...

journal_title：Experimental and therapeutic medicine

authors： Kito Y,Iida M,Tanabe K,Onuma T,Tsujimoto M,Nagase K,Tokuda H,Iwama T,Kozawa O,Iida H

更新日期：2019-11-01 00:00:00

abstract：:The purpose of the present study was to assess the effects of single-session dietary counseling on salt restriction in Japanese cardiology outpatients as assessed using spot urine measurements. A total of 72 patients (73±11 years old, including 30 females) who visited a cardiology outpatient clinic and had a salt inta...

journal_title：Experimental and therapeutic medicine

authors： Yamasaki T,Sadanaga T,Hirota S

更新日期：2015-07-01 00:00:00

abstract：:The aim of the present study was to investigate whether magnolol, the essential component of the traditional Chinese medicine, Magnolia officinalis, can pass through liver X receptor α (LXRα), to subsequently play an important role in the lipid metabolic balance. Using a HepG2 human hepatoma cell line, mammalian cellu...

journal_title：Experimental and therapeutic medicine

authors： Xie NA,Hu C,Guo A,Liang H,DU P,Yin G

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to investigate the association between metabolic syndrome (MS) and vascular endothelial cell dysfunction (ECD) in adolescents. Sixty obese pediatric inpatients at the General Hospital of Tianjin Medical University from February 2011 to February 2012 were included. Among these, 30 patients wer...

journal_title：Experimental and therapeutic medicine

authors： Wei Y,Liu G,Yang J,Zheng R,Jiang L,Bao P

更新日期：2013-06-01 00:00:00

abstract：:Hypertension is a very common cardiovascular disorder, however, the molecular mechanism underlying this disease remains poorly understood. Recently, an increasing number of studies have demonstrated that mitochondrial (mt)DNA mutations serve important roles in the pathogenesis of hypertension. The current study report...

journal_title：Experimental and therapeutic medicine

authors： Lin L,Cui P,Qiu Z,Wang M,Yu Y,Wang J,Sun Q,Zhao H

更新日期：2019-03-01 00:00:00

abstract：:Radiation pneumonitis is a clinical problem with a high incidence. Once the onset of radiation pneumonitis has occurred, the administration of antioxidants and anti-inflammatory agents is the most commonly used method of clinical treatment. Quercetin (Que) is a common flavonoid, with potent anti-inflammatory and anti-...

journal_title：Experimental and therapeutic medicine

authors： Qin M,Chen W,Cui J,Li W,Liu D,Zhang W

更新日期：2017-12-01 00:00:00