Abstract:
BACKGROUND:Computed tomography (CT) annular measurements are predictive of paravalvular regurgitation after transcatheter aortic valve replacement (TAVR) which is a predictor of mortality and morbidity. OBJECTIVES:To demonstrate the rationale and potential implications of new CT sizing recommendations for TAVR. METHODS:The CT sizing recommendations aim to ensure routine transcatheter heart valve (THV) oversizing of the aortic annular area [(THV external area/systolic annular area - 1) × 100; range, 1%-20%; target, 10%-15%]. Consecutive patients (n = 120) underwent CT before TAVR with balloon-expandable valves sized by transesophageal echocardiography (TEE). Retrospectively, the CT-recommended THV size was compared with the actual size implanted. RESULTS:Compared with TEE, application of the newly developed CT-based sizing recommendations would have led to implantation of a larger valve in 33.3% (40/120), no change in valve size in 55.8% (67/120), and a smaller valve in 10.8% (13/120). In patients when CT recommended a larger valve, the incidence of at least moderate paravalvular regurgitation was 25% (10/40) compared with 4.5% (3/67; P < 0.01) when both TEE and CT recommendations were in agreement. Using diastolic versus systolic CT measurements results in 20% of patients receiving smaller THVs. TEE sizing resulted in 33.3% (40/120) of valves being undersized (THV area < CT systolic annular area) with a mean annular oversizing of 9.4% ± 17.4% (range: -21.5% to 65.9%) without annular rupture. In contrast, the CT sizing recommendations results in mean annular oversizing of 13.9% ± 8.0% (range, 1.3%-29.8%). CONCLUSION:These CT sizing recommendations enable standardized moderate overexpansion of the aortic annulus. Clinical outcomes from these recommendations are being prospectively assessed in a multicenter trial.
journal_name
J Cardiovasc Comput Tomogrjournal_title
Journal of cardiovascular computed tomographyauthors
Willson AB,Webb JG,Freeman M,Wood DA,Gurvitch R,Thompson CR,Moss RR,Toggweiler S,Binder RK,Munt B,Cheung A,Hague C,Ye J,Leipsic JAdoi
10.1016/j.jcct.2012.10.002subject
Has Abstractpub_date
2012-11-01 00:00:00pages
406-14issue
6eissn
1934-5925issn
1876-861Xpii
S1934-5925(12)00357-7journal_volume
6pub_type
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of cardiovascular computed tomography
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更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2008.09.002
更新日期:2008-11-01 00:00:00
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journal_title:Journal of cardiovascular computed tomography
pub_type: 共识发展会议,杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2019.11.003
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更新日期:2013-09-01 00:00:00
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