Abstract:
OBJECTIVES:Late contrast enhancement visualizes myocardial infarction, but the contrast to noise ratio (CNR) is low using conventional CT. The aim of this study was to determine if spectral CT can improve imaging of myocardial infarction. MATERIALS AND METHODS:A canine model of myocardial infarction was produced in 8 animals (90-min occlusion, reperfusion). Later, imaging was performed after contrast injection using CT at 90 kVp/150 kVpSn. The following reconstructions were evaluated: Single energy 90 kVp, mixed, iodine map, multiple monoenergetic conventional and monoenergetic noise optimized reconstructions. Regions of interest were measured in infarct and remote regions to calculate contrast to noise ratio (CNR) and Bhattacharya distance (a metric of the differentiation between regions). Blinded assessment of image quality was performed. The same reconstruction methods were applied to CT scans of four patients with known infarcts. RESULTS:For animal studies, the highest CNR for infarct vs. myocardium was achieved in the lowest keV (40 keV) VMo images (CNR 4.42, IQR 3.64-5.53), which was superior to 90 kVp, mixed and iodine map (p = 0.008, p = 0.002, p < 0.001, respectively). Compared to 90 kVp and iodine map, the 40 keV VMo reconstructions showed significantly higher histogram separation (p = 0.042 and p < 0.0001, respectively). The VMo reconstructions showed the highest rate of excellent quality scores. A similar pattern was seen in human studies, with CNRs for infarct maximized at the lowest keV optimized reconstruction (CNR 4.44, IQR 2.86-5.94). CONCLUSIONS:Dual energy in conjunction with noise-optimized monoenergetic post-processing improves CNR of myocardial infarct delineation by approximately 20-25%.
journal_name
J Cardiovasc Comput Tomogrjournal_title
Journal of cardiovascular computed tomographyauthors
Sandfort V,Palanisamy S,Symons R,Pourmorteza A,Ahlman MA,Rice K,Thomas T,Davies-Venn C,Krauss B,Kwan A,Pandey A,Zimmerman SL,Bluemke DAdoi
10.1016/j.jcct.2017.02.003subject
Has Abstractpub_date
2017-01-01 00:00:00pages
171-178issue
3eissn
1934-5925issn
1876-861Xpii
S1934-5925(17)30039-4journal_volume
11pub_type
杂志文章abstract::We present a case that demonstrates myocardial fibrosis detected on a cardiac computed tomography study performed for the evaluation of chest pain in a patient with hypertrophic cardiomyopathy. We describe the correlation between echocardiographic strain imaging, quantitative positron emission tomography, and computed...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2013.12.019
更新日期:2014-03-01 00:00:00
abstract::Computed tomography (CT) plays an important role in the workup of patients who are candidates for implantation of a catheter-based aortic valve, a procedure referred to as transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR). Contrast-enhanced CT imaging provides information ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.jcct.2012.11.002
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Catheter ablation (CA) is an established therapy for selected patients with atrial fibrillation (AF), but predictors of CA ablation outcome are still not fully elucidated. The aim of the study was to identify structural and morphological parameters from computed tomography (CT) as predictors of successful CA ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2018.06.005
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Randomized trials have shown favorable clinical outcomes for coronary CT angiography (CTA) in patients with suspected acute coronary syndrome (ACS). Our goal was to estimate the cost-effectiveness of coronary CTA as compared to alternative management strategies for ACP patients over lifetime. METHODS:Markov...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2019.06.008
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To review the imaging features of coronary artery-to-pulmonary artery fistula (CPAF) on CT coronary angiography (CTCA) and evaluate its diagnostic performance compared with coronary catheter angiography (CCA) and transthoracic echocardiography (TTE). MATERIALS AND METHODS:We retrospectively reviewed with a d...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2018.10.013
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to test the diagnostic accuracy of myocardial CT perfusion (CTP) imaging using color and gray-scale image analysis. BACKGROUND:Current myocardial CTP techniques have varying diagnostic accuracy and are prone to artifacts that impair detection. This study evaluated the diagnost...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2011.10.006
更新日期:2011-11-01 00:00:00
abstract::Pulmonary artery intramural hematoma is a very rare condition that can occur isolated or in patients with aortic dissection, usually of Stanford type A. We present a rare case of pulmonary artery intramural hematoma associated with a Stanford type B aortic dissection in an 85-year-old man. ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2015.05.004
更新日期:2015-09-01 00:00:00
abstract::Perivascular adipose tissue (PVAT) surrounding the human coronary arteries, secretes a wide range of adipocytokines affecting the biology of the adjacent vascular wall in a paracrine way. However, we have recently found that PVAT also behaves as a sensor of signals coming from the vascular wall, to which it reacts by ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,评审
doi:10.1016/j.jcct.2019.03.006
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:There is concern regarding the administration of iodinated contrast to patients with impaired renal function because of the increased risk of contrast-induced nephropathy. OBJECTIVE:Evaluate image quality and feasibility of a protocol with a reduced volume of iodinated contrast and utilization of dual-energ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcct.2014.06.003
更新日期:2014-07-01 00:00:00
abstract::Magnetic particle imaging (MPI) is a new medical imaging technique which performs a direct measurement of magnetic nanoparticles, also known as superparamagnetic iron oxide. MPI can acquire quantitative images of the local distribution of the magnetic material with high spatial and temporal resolution. Its sensitivity...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2012.04.007
更新日期:2012-05-01 00:00:00
abstract::We present an illustrative case of a very rare complication of saphenous bypass: a huge aneurysm that severely compresses the right-heart cavities. ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2017.02.005
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Myocardial fibrosis (MF) occurs in up to 80% of subjects with asymptomatic or mildly symptomatic hypertrophic cardiomyopathy (HCM) and can constitute an arrhythmogenic substrate for re-entrant, life-threatening ventricular arrhythmias in predisposed persons. OBJECTIVE:The aim was to investigate whether MF d...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2013.04.002
更新日期:2013-05-01 00:00:00
abstract::Myocardial bridging describes the clinical entity whereby a segment of coronary artery is either partially or completely covered by surrounding myocardium. It represents the most frequent congenital coronary anomaly and has an estimated prevalence of ≤13% on angiographic series. With the emergence of cardiac computed ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jcct.2011.10.015
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The optimization of myocardial CT perfusion (CTP) assessment remains inconsistent and uncertain. Our aim was to explore the superior analysis selection and incremental improvement of myocardial blood flow (MBF) assessment on CTP in diagnosing hemodynamically significant coronary artery disease (CAD). METHOD...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2020.01.010
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Data are limited on using 64-slice multidetector computed tomography (MDCT) as a gatekeeper to cardiac catheterization in patients with mild abnormalities on myocardial perfusion stress imaging (MPI). OBJECTIVE:We compared the rate of invasive coronary angiography (ICA) within 6 months after finding mildly ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2008.09.002
更新日期:2008-11-01 00:00:00
abstract::Cardiac CT offers several approaches to establish the hemodynamic severity of coronary artery obstructions. Dynamic myocardial perfusion CT (MPICT) is based on serial CT imaging to measure the inflow of contrast medium into the myocardium and calculate absolute measures of myocardial perfusion. This review describes t...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,评审
doi:10.1016/j.jcct.2019.09.003
更新日期:2020-01-01 00:00:00
abstract::In this article, we review the current status and discuss potential further improvements and limitations of system parameters relevant for cardiac CT, in particular spatial resolution, temporal resolution, and volume coverage. ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,评审
doi:10.1016/j.jcct.2009.04.004
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:There have been no reports about the diagnostic ability of coronary computed tomography angiography (CTA) in evaluating collateral channels used for retrograde chronic total occlusion (CTO) percutaneous coronary intervention (PCI). OBJECTIVE:We investigated the ability and diagnostic accuracy of coronary CT...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2016.01.003
更新日期:2016-03-01 00:00:00
abstract:AIMS:Fractional flow reserve (FFR) pullback allows to assess the distribution of pressure loss along the coronary vessels. FFR derived from CT (FFRCT) provides a virtual pullback curve that may also aid in the assessment of the distribution of epicardial coronary resistance in the non-invasive setting. The present stud...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2019.09.004
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To investigate the anatomical features related to the failure of cryoballoon (CB) ablation for atrial fibrillation (AF) on pre-procedural CT images. METHODS:We retrospectively analyzed CT images of 100 patients with AF who had undergone a first CB ablation at our institution between June 2016 and April 2017...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2018.11.005
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Sudden cardiac death is the leading cause of death among firefighters in the United States. Fire departments commonly maintain physical examination protocols, often with exercise stress testing, to detect risk of coronary heart disease. OBJECTIVE:We sought to determine whether coronary calcium detected by e...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2012.07.003
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Coronary computed tomography angiography (CCTA) left ventricle (LV) volumes have prognostic value. LV measurements however can differ depending on post-processing software. Two common methods are the contour (CON) or attenuation (ATT) based methods. This study aims to determine differences in LV volume measu...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2019.08.003
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Most unexpected cardiovascular events occur in persons at intermediate risk of coronary artery disease (10%-20% 10-year risk). Coronary artery calcium (CAC) has been shown to be highly specific for atherosclerosis, occurring only in the intima of the coronary arteries. Evidence shows that elevated coronary c...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jcct.2007.10.001
更新日期:2007-12-01 00:00:00
abstract::We present the case of a neonate with pulmonary atresia and persistent bilateral patent ductus arteriosus imaged by gated multidetector CT. Traditionally, these patients have been assessed preoperatively with invasive angiocardiography or with cardiovascular magnetic resonance under sedation. Our case illustrates that...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2015.03.008
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Computed tomography (CT) annular measurements are predictive of paravalvular regurgitation after transcatheter aortic valve replacement (TAVR) which is a predictor of mortality and morbidity. OBJECTIVES:To demonstrate the rationale and potential implications of new CT sizing recommendations for TAVR. METHO...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2012.10.002
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Risk assessment in the extensive calcified plaque phenotype has been limited by small sample size. OBJECTIVE:We studied all-cause mortality rates among asymptomatic patients with markedly elevated Agatston scores > 1000. METHODS:We studied a clinical cohort of 44,052 asymptomatic patients referred for coro...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcct.2013.12.002
更新日期:2014-01-01 00:00:00
abstract::A 41-year-old male with prior history of aortic root replacement for infectious endocarditis was found to have a pseudoaneurysm in the fibrous continuity between the aortic and mitral valves: the so called "mitral-aortic intervalvular fibrosa." Preoperative cardiac-gated computed tomographic angiography and intraopera...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2011.03.006
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:When coronary calcium scoring is performed in patients with suspected coronary artery disease, a separate noncontrast scan is acquired before contrast-enhanced coronary CT angiography (CTA). OBJECTIVE:Our aim was to develop and validate an automated method for calculating the coronary calcium score (CCS) fr...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcct.2015.06.001
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:To determine the predictive value of volumetrically measured lung perfusion defects (PDvol) and right ventricular dysfunction on dual-energy computed tomography angiography (DE-CTA) for predicting all cause mortality in patients suspected of pulmonary embolism (PE) but without evident thromboembolic clot on ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcct.2017.04.005
更新日期:2017-01-01 00:00:00
abstract::Here, we report about a 34-year-old man with tuberous sclerosis. During routine surveillance, a CT scan of the chest incidentally showed a low-attenuation streak within the left ventricle. Cardiac magnetic resonance imaging confirmed intramyocardial lipid deposition within the left ventricle. Tuberous sclerosis is an ...
journal_title:Journal of cardiovascular computed tomography
pub_type: 杂志文章
doi:10.1016/j.jcct.2013.06.249
更新日期:2013-07-01 00:00:00