Abstract：
:ObjectiveTo assess the feasibility of dual energy CT (DECT) to derive myocardial extracellular volume (ECV) and detect myocardial ECV differences without a non-contrast acquisition, compared to single energy CT (SECT). MethodsSubjects (n = 35) with focal fibrosis (n = 17), diffuse fibrosis (n = 10), and controls (n = 9) underwent non-contrast and delayed acquisitions to calculate SECT-ECV. DECT-ECV was calculated using the delayed acquisition and the derived virtual non-contrast images. In the control and diffuse fibrotic groups, the entire myocardium of the left ventricle was used to calculate ECV. Two ROIs were placed in the focal fibrotic group, one in normal and one in fibrotic myocardium. ResultsMedian ECV was 33.4% (IQR, 30.1-37.4) using SECT and 34.9% (IQR, 31.2-39.2) using DECT (p = 0.401). For both techniques, focal and diffuse fibrosis had significantly higher ECV values (all p < 0.021) than normal myocardium. There was no systematic bias between DECT and SECT (p = 0.348). SECT had a higher radiation dose (1.1 mSv difference) than DECT (p < 0.001). ConclusionECV can be measured using a DECT approach with only a delayed acquisition. The DECT approach provides similar results at a lower radiation dose compared to SECT.
journal_name
J Cardiovasc Comput Tomogrjournal_title
Journal of cardiovascular computed tomographyauthors
van Assen M,De Cecco CN,Sahbaee P,Eid MH,Griffith LP,Bauer MJ,Savage RH,Varga-Szemes A,Oudkerk M,Vliegenthart R,Schoepf UJdoi
10.1016/j.jcct.2018.10.011subject
Has Abstractpub_date
2019-01-01 00:00:00pages
81-84issue
1eissn
1934-5925issn
1876-861Xpii
S1934-5925(18)30166-7journal_volume
13pub_type
杂志文章abstract：BACKGROUND:There is concern regarding the administration of iodinated contrast to patients with impaired renal function because of the increased risk of contrast-induced nephropathy. OBJECTIVE:Evaluate image quality and feasibility of a protocol with a reduced volume of iodinated contrast and utilization of dual-energ...
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