Zinc protoporphyrin levels have added value in the prediction of low hemoglobin deferral in whole blood donors.

Abstract:

BACKGROUND:Increased zinc protoporphyrin (ZPP) levels can indicate iron deficiency and may be predictive for low hemoglobin (Hb) deferral in blood donors. Prediction models for Hb deferral in whole blood donors have already been developed. In this study, we examined if addition of ZPP to these prediction models improves risk estimation of Hb deferral. STUDY DESIGN AND METHODS:This study included 4598 Dutch whole blood donors. Information on ZPP levels measured at the previous visit was added to the existing prediction models to estimate the risk of Hb deferral. Models were compared using the following measures: concordance (c)-statistic, continuous net reclassification improvement (NRI), and clinical net benefit (NB). RESULTS:Seventy-six male donors (2.9%) and 69 female donors (3.5%) were deferred because of a low Hb level. Previous ZPP level was associated with risk of Hb deferral (odds ratio for interquartile range of previous ZPP level, men 2.0 [95% confidence interval {CI}, 1.7-2.3]; women 2.2 [95% CI, 1.9-2.4]) in a multivariable risk model. Addition of ZPP into the models resulted in an increase of the c-statistic from 0.93 to 0.94 for men and from 0.80 to 0.85 for women. The added value of ZPP was confirmed by measures of clinical usefulness. NRI for men was 0.42, and for women, 0.56. At relevant threshold probabilities between 10 and 15%, NB was higher for models considering ZPP. CONCLUSION:This study shows that ZPP measurements obtained at the previous visit may have added value in the risk prediction of Hb deferral in whole blood donors.

journal_name

Transfusion

journal_title

Transfusion

authors

Baart AM,de Kort WL,Moons KG,Atsma F,Vergouwe Y

doi

10.1111/j.1537-2995.2012.03957.x

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

1661-9

issue

8

eissn

0041-1132

issn

1537-2995

journal_volume

53

pub_type

临床试验,杂志文章
  • The antiglobulin reaction with native and enzyme-modified red cells.

    abstract::The quantity of anti-IgG bound at equilibrium to cell-bound anti-D failed to increase with enzymatic modification of intact red blood cells. This contrasts with results obtained by immunoelectronmicroscopy with unsealed red blood cell ghosts. Ghosts derived from enzyme-modified, anti-D-sensitized intact red blood cell...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1980.20480260268.x

    authors: Rearden A,Masouredis SP

    更新日期:1980-07-01 00:00:00

  • The Brazilian experience of nucleic acid testing to detect human immunodeficiency virus, hepatitis C virus, and hepatitis B virus infections in blood donors.

    abstract:BACKGROUND:The history of the development and implementation of the Brazilian nucleic acid testing (NAT) platform to detect and discriminate among human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) infections in blood donors is described here. The results for the sensitivity, repro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14478

    authors: Rocha D,Andrade E,Godoy DT,Fontana-Maurell M,Costa E,Ribeiro M,Ferreira AGP,Brindeiro R,Tanuri A,Alvarez P

    更新日期:2018-04-01 00:00:00

  • Red cell use during cesarean delivery.

    abstract::The transfusion of red cells (RBCs) was analyzed over a 4-year period (1984-1987), during which 9596 cesarean deliveries were performed. A total of 336 patients were identified as receiving RBC transfusions during or after cesarean delivery; 747 units of RBCs were administered. The overall incidence of transfusion in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31191096177.x

    authors: Camann WR,Datta S

    更新日期:1991-01-01 00:00:00

  • "Pseudo-hemolytic" transfusion reaction caused by intravenous iron-dextran therapy.

    abstract::Intravenous iron-dextran therapy can cause a red-brown discoloration of the plasma, simulating a hemolytic transfusion reaction. A rapid and simple test to differentiate between true hemolysis and plasma discoloration due to circulating iron-dextran complexes is described. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22482251227.x

    authors: Simon SD,Kuriyan MA,Kim HC

    更新日期:1982-07-01 00:00:00

  • Sickle Hb polymerization in RBC components from donors with sickle cell trait prevents effective WBC reduction by filtration.

    abstract:BACKGROUND:RBC components collected from donors with sickle cell trait frequently occlude WBC-reduction filters. In vitro, sickle trait RBCs have the potential for sickle Hb (Hb S) polymerization at low oxygen saturations and high Hb concentrations. STUDY DESIGN AND METHOD:To determine if the low pH and high osmolarit...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00206.x

    authors: Stroncek DF,Rainer T,Sharon V,Byrne KM,Noguchi CT,Klein HG,Schechter AN,Leitman SF

    更新日期:2002-11-01 00:00:00

  • Transfusion of ABO-nonidentical platelets is not associated with adverse clinical outcomes in cardiovascular surgery patients.

    abstract:BACKGROUND:Current blood transfusion standards in Canada and the United States permit transfusion of ABO-nonidentical platelets when ABO-identical platelets are not available. This practice increases the availability of platelets, a component in chronic shortage in Ontario, Canada because of the 5-day shelf-life. The i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00037.x

    authors: Lin Y,Callum JL,Coovadia AS,Murphy PM

    更新日期:2002-02-01 00:00:00

  • Role of glycoprotein Ibalpha in phagocytosis of platelets by macrophages.

    abstract:BACKGROUND:Platelet (PLT) storage at 0 to 4 degrees C suppresses bacterial multiplication, but induces clusters of glycoprotein (GP) Ibalpha that trigger their phagocytosis by macrophages and reduce their survival after transfusion. A method was sought that detects cold-induced changes in GPIbalpha involved in phagocyt...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.01034.x

    authors: Badlou BA,Spierenburg G,Ulrichts H,Deckmyn H,Smid WM,Akkerman JW

    更新日期:2006-12-01 00:00:00

  • Increasing the economic efficacy of peripheral blood progenitor cell collections by monitoring peripheral blood CD34+ concentrations.

    abstract:BACKGROUND:After mobilization, the collection of peripheral blood progenitor cells (PBPCs) can either be started a fixed number of days after having passed the white blood cell nadir (fixed-day scheme) or be based on monitoring of CD34+ cells. This study was conducted to compare both approaches and to assess possible f...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02466.x

    authors: Gutensohn K,Magens MM,Kuehnl P,Zeller W

    更新日期:2010-03-01 00:00:00

  • Acquisition of cytomegalovirus infection in infants following exchange transfusion: a prospective study.

    abstract::A prospective study of newborn infants who required exchange transfusion was undertaken to evaluate the risk of transmission of cytomegalovirus (CMV). Buffy coat-, urine- and saliva-saturated throat swabs for viral cultures and serum specimens for CMV complement-fixing (CF) antibody were obtained from 45 infant-mother...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1980.20380214901.x

    authors: Kumar A,Nankervis GA,Cooper AR,Gold E,Kumar ML

    更新日期:1980-05-01 00:00:00

  • Tranexamic acid in remote damage control resuscitation.

    abstract::With the advent of remote damage control resuscitation and far-forward surgery, a renewed emphasis has been placed on examining a variety of pharmacologic adjuncts to controlling blood loss before definitive operative intervention. In this paper, the authors review the current state of the art for tranexamic acid (TXA...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12042

    authors: Rappold JF,Pusateri AE

    更新日期:2013-01-01 00:00:00

  • Geographic exposure risk of variant Creutzfeldt-Jakob disease in US blood donors: a risk-ranking model to evaluate alternative donor-deferral policies.

    abstract:BACKGROUND:Variant Creutzfeldt-Jakob disease (vCJD) has been transmitted by blood transfusion (TTvCJD). The US Food and Drug Administration (FDA) recommends deferring blood donors who resided in or traveled to 30 European countries where they may have been exposed to bovine spongiform encephalopathy (BSE) through beef ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13971

    authors: Yang H,Huang Y,Gregori L,Asher DM,Bui T,Forshee RA,Anderson SA

    更新日期:2017-04-01 00:00:00

  • Validation of new real-time polymerase chain reaction assays for detection of hepatitis A virus RNA and parvovirus B19 DNA.

    abstract:BACKGROUND:To meet European guidelines for plasma for fractionation, plasma fractionators have implemented parvovirus B19 (B19V) and hepatitis A virus (HAV) nucleic acid test (NAT) screening on test pools. In this study we evaluate recently developed in-house NAT assays for B19V DNA and HAV RNA. The B19V NAT was design...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13334

    authors: Molenaar-de Backer MW,de Waal M,Sjerps MC,Koppelman MH

    更新日期:2016-02-01 00:00:00

  • Validation of simple prediction algorithms to consistently achieve CD3+ and postselection CD34+ targets with leukapheresis.

    abstract:BACKGROUND:Cellular therapies using engineered T cells, haploidentical transplants, and autologous gene therapy are increasing. Specified CD3+ or high CD34+ doses are typically required for subsequent manufacturing, manipulation, or CD34+ selection. Simple, practical, and reliable lymphocyte and hematopoietic progenito...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15576

    authors: Yoon EJ,Zhang J,Weinberg RS,Brochstein JA,Nandi V,Sachais BS,Shi PA

    更新日期:2020-01-01 00:00:00

  • AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections.

    abstract::Transfusion-transmitted cytomegalovirus (TT-CMV) is often asymptomatic, but certain patient populations, such as very low birth weight neonates, fetuses requiring intrauterine transfusion, pregnant women, patients with primary immunodeficiencies, transplant recipients, and patients receiving chemotherapy or transplant...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13503

    authors: AABB, Clinical Transfusion Medicine Committee.,Heddle NM,Boeckh M,Grossman B,Jacobson J,Kleinman S,Tobian AA,Webert K,Wong EC,Roback JD

    更新日期:2016-06-01 00:00:00

  • A highly specialized and motivated volunteer population: platelet donors.

    abstract::The plateletpheresis program of the M.D. Anderson Hospital was established in 1963. Approximately 20,000 units of platelet concentrates are produced per year. Credit for the nonreplacement fee generates the greatest number of donors. No organized recruitment campaign exists. Each donor becomes a recruiter for the prog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17377196353.x

    authors: Wendlandt GM,Lichtiger B

    更新日期:1977-05-01 00:00:00

  • Therapeutic plasma exchange and intravenous immunoglobulin as primary therapy for D alloimmunization in pregnancy precludes the need for intrauterine transfusion.

    abstract:BACKGROUND:Maternal D alloimmunization detected in early gestation requires aggressive intervention to prevent severe fetal anemia. An intrauterine transfusion (IUT) is indicated to prevent fetal death once severe fetal anemia has been detected, but is not without risk. Protocols combining therapeutic plasma exchange (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12633

    authors: Bellone M,Boctor FN

    更新日期:2014-08-01 00:00:00

  • Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities.

    abstract:BACKGROUND:Fresh-frozen plasma (FFP) is frequently transfused to patients with mild prolongation of coagulation values under the assumption that FFP will correct the coagulopathy. There is little evidence to support this practice, however. To determine the effect of FFP on coagulation variables and correlation with ble...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00891.x

    authors: Abdel-Wahab OI,Healy B,Dzik WH

    更新日期:2006-08-01 00:00:00

  • Evaluation and improvement of blood donor educational materials: results from a multicenter randomized controlled trial.

    abstract:BACKGROUND:Blood collection centers are charged with creating donor educational materials (DnEM) that are easily understood across all prospective donor populations, while addressing mandates and recommendations from regulatory agencies and professional standard setting organizations. Donors must have sufficient inform...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15866

    authors: Wehrli G,Rossmann SN,Waxman DA,Katz LM

    更新日期:2020-08-01 00:00:00

  • A nonenveloped virus with a lipid envelope: hepatitis A virus as used in virus-reduction studies.

    abstract:BACKGROUND:Recently, a quasi-lipid-enveloped (LE) form of the traditionally nonlipid-enveloped (NLE) hepatitis A virus (HAV) was described in human serum and cell culture-derived HAV stocks. This discovery challenges the understanding of HAV reduction in virus clearance studies of plasma products, which were performed ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14091

    authors: Kapsch AM,Farcet MR,Antoine G,Kreil TR

    更新日期:2017-06-01 00:00:00

  • Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome.

    abstract:BACKGROUND:There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting pa...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.1999.39101070.x

    authors: Bracey AW,Radovancevic R,Riggs SA,Houston S,Cozart H,Vaughn WK,Radovancevic B,McAllister HA Jr,Cooley DA

    更新日期:1999-10-01 00:00:00

  • Blood transfusion safety in sub-Saharan Africa: A literature review of changes and challenges in the 21st century.

    abstract:BACKGROUND:Access to a safe, adequate blood supply has proven challenging in sub-Saharan Africa, where systemic deficiencies spanning policy, collections, testing, and posttransfusion surveillance have long been recognized. Progress in transfusion safety in the early 2000s was in large part due to intervention by the W...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.14949

    authors: Weimer A,Tagny CT,Tapko JB,Gouws C,Tobian AAR,Ness PM,Bloch EM

    更新日期:2019-01-01 00:00:00

  • Prevalence of selected viral infections among temporarily deferred donors who returned to donate blood: American Red Cross blood donor study.

    abstract:BACKGROUND:Health history questions are introduced into the predonation interview to identify blood donors believed to pose a higher risk of infectious diseases to recipients. This study assesses the current impact of some of those questions. STUDY DESIGN AND METHODS:Donor deferral and donation data were extracted fro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00577.x

    authors: Zou S,Musavi F,Notari EP 4th,Fujii KE,Dodd RY,ARCNET Study Group.

    更新日期:2005-10-01 00:00:00

  • Improved removal of white cells with minimal platelet loss by filtration of apheresis platelets during collection.

    abstract:BACKGROUND:Filtration of apheresis platelets to remove white cells (WBCs) requires operator intervention after the collection procedure (postcollection filtration), which may cause variable and unsatisfactory filter performance (WBC removal and platelet loss). The MCS+ LN9000 apheresis system filters platelets through ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39199116898.x

    authors: Holme S,Andres M,Goermar N,Giordano GF

    更新日期:1999-01-01 00:00:00

  • Transfusion-acquired hepatitis C: the Danish lookback experience. The Danish HCV [hepatitis C virus] Lookback Group.

    abstract:BACKGROUND:In 1996, the Danish National Board of Health recommended hepatitis C virus (HCV) lookback to identify recipients of blood components from donors found to be positive since the implementation of anti-HCV screening in 1991. STUDY DESIGN AND METHODS:The aim was to accumulate results of the lookback at a nation...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39299154734.x

    authors: Christensen PB,Groenbaek K,Krarup HB

    更新日期:1999-02-01 00:00:00

  • Dynamics of shape recovery by stored red blood cells during washing at the single cell level.

    abstract:BACKGROUND:Hypothermic storage transforms red blood cells (RBC) from smooth biconcave discocytes into increasingly spherical spiculated echinocytes and, ultimately, fragile spherocytes (S). Individual cells undergo this transformation at different rates, producing a heterogeneous mixture of RBCs at all stages of echino...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15979

    authors: Lu M,Shevkoplyas SS

    更新日期:2020-08-04 00:00:00

  • Clotting factors in supernatant plasma following cryoprecipitation.

    abstract::The supernatant plasma which remains after cryoprecipitation is a useful component for transfusion therapy. However, from prior studies it was unclear how well plasma clotting factors were preserved following cryoprecipitation. Coagulation factor assays were performed on fresh plasma, supematant plasma after removal o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.1974.tb04509.x

    authors: Roth GJ,Tobias KI

    更新日期:1974-03-01 00:00:00

  • Ultrastructural localization of glycoprotein IIIa (GPIIIa, beta 3 integrin) on placental syncytiotrophoblast microvilli: implications for platelet alloimmunization during pregnancy.

    abstract:BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a more commonly occurs in first pregnancies, unlike hemolytic disease of the newborn. Anti-D is produced after D+ fetomaternal hemorrhage; this usually occurs at parturition. Anti-HPA-1a could develop during pregnancy if...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01832.x

    authors: Kumpel BM,Sibley K,Jackson DJ,White G,Soothill PW

    更新日期:2008-10-01 00:00:00

  • ADAMTS13: origins, applications, and prospects.

    abstract::ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF) multimers from the vasculature in a highly regulated manner. In pathologic states such as thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMAs), VWF can bind to the endothelium and form large multime...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.14804

    authors: Plautz WE,Raval JS,Dyer MR,Rollins-Raval MA,Zuckerbraun BS,Neal MD

    更新日期:2018-10-01 00:00:00

  • A new radioimmunoassay for the detection of small amounts of white cells and platelets in red cell concentrates: implications for blood transfusion.

    abstract::In the procedure for quality control of red cell concentrates, made white cell (WBC)-poor by filtration, the particle-counting technique was found to be insufficiently sensitive in detecting the remaining WBCs and platelets. Therefore, direct radioimmunoassays were developed using murine monoclonal antibodies specific...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30290162896.x

    authors: Webster MR,Prins HK,Huisman JG

    更新日期:1990-02-01 00:00:00

  • Platelet storage. Effects of leachable materials on morphology and function.

    abstract::A polyolefin plastic (PL 732) bag formulated without liquid plasticizer allows storage of platelets for 5 and, now, up to 7 days. In order to assess the leaching of compounds from this new plastic, extracts of the supernatant from platelet concentrates stored in these bags were analyzed by high-performance liquid chro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26486262743.x

    authors: Labow RS,Tocchi M,Rock G

    更新日期:1986-07-01 00:00:00