Tranexamic acid in remote damage control resuscitation.

Abstract:

:With the advent of remote damage control resuscitation and far-forward surgery, a renewed emphasis has been placed on examining a variety of pharmacologic adjuncts to controlling blood loss before definitive operative intervention. In this paper, the authors review the current state of the art for tranexamic acid (TXA) and its potential benefits to those patients who are in need of a massive transfusion. Specifically addressed are its biologic and pharmacologic properties, as well the results of a number of recent studies. The 2010 CRASH-2 trial randomized in excess of 20,000 patients and demonstrated a reduction in all-cause mortality from 16.0 to 14.5% and death due to bleeding from 5.7 to 4.9%. The 2012 Military Application of Tranexamic Acid in Trauma Emergency Resuscitation study provided a retrospective analysis of 896 wounded cared for at a military hospital in Afghanistan. This study demonstrated a 23.9%-17.4% reduction in all-cause mortality. Finally, they discuss the potential complications associated with TXA use as well as areas of future research, which are needed to solidify our knowledge of TXA and its potential beneficial effects on controlling bleeding.

journal_name

Transfusion

journal_title

Transfusion

authors

Rappold JF,Pusateri AE

doi

10.1111/trf.12042

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

96S-99S

eissn

0041-1132

issn

1537-2995

journal_volume

53 Suppl 1

pub_type

杂志文章,评审
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  • Comparative evaluation of platelet counts in two hematology analyzers and potential effects on prophylactic platelet transfusion decisions.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/trf.14968

    authors: Vanspranghels R,Houfflin-Debarge V,Vaast P,Coulon C,Clouqueur E,Hanssens S,Rakza T,Subtil D,Garabedian C

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    journal_title:Transfusion

    pub_type: 杂志文章

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    journal_title:Transfusion

    pub_type: 杂志文章

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    authors: Daniels GL,Okubo Y,Yamaguchi H,Seno T,Ikuta M

    更新日期:1989-11-01 00:00:00

  • Development of a quality monitoring program for platelet components: a report of the first four years' experience at Canadian Blood Services.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03402.x

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    pub_type: 杂志文章

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  • Complement activation and adult respiratory distress syndrome during intermittent flow apheresis procedures.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26186124040.x

    authors: Boogaerts MA,Roelant C,Goossens W,Verwilghen RL

    更新日期:1986-01-01 00:00:00

  • Anti-Holley (hy): characterization of another example.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15676082238.x

    authors: Hsu TC,Jagathambal K,Sabo BH,Sawitsky A

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  • "Pseudo-hemolytic" transfusion reaction caused by intravenous iron-dextran therapy.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22482251227.x

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    更新日期:1982-07-01 00:00:00

  • Demonstration of gene dosage effects on antigens in the Duffy, Ss, and Rh systems using an enzyme-linked immunosorbent assay.

    abstract::Using a recently developed enzyme-linked immunosorbent assay, gene dosage effects were demonstrated for the Duffy, Ss, and Rh red blood cell antigen systems. We report a comparison by an antibody-binding assay of the relative amounts of Fya and Fyb antigens on FyaFya, FyaFyb, FybFyb, FyaFyx, and FyxFyx erthrocytes, an...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22683068606.x

    authors: Caren LD,Bellavance R,Grumet FC

    更新日期:1982-11-01 00:00:00

  • Effectiveness and cost analysis of "just-in-time" salvage plerixafor administration in autologous transplant patients with poor stem cell mobilization kinetics.

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    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03136.x

    authors: Li J,Hamilton E,Vaughn L,Graiser M,Renfroe H,Lechowicz MJ,Langston A,Prichard JM,Anderson D,Gleason C,Lonial S,Flowers CR,Kaufman JL,Waller EK

    更新日期:2011-10-01 00:00:00

  • Prevention of bedside errors in transfusion medicine (PROBE-TM) study: a cluster-randomized, matched-paired clinical areas trial of a simple intervention to reduce errors in the pretransfusion bedside check.

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    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1537-2995.2007.01189.x

    authors: Murphy MF,Casbard AC,Ballard S,Shulman IA,Heddle N,Aubuchon JP,Wendel S,Thomson A,Hervig T,Downes K,Carey PM,Dzik WH,BEST Research Collaborative.

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  • Absence of acute adverse in vitro effects on aged AS-1 red blood cells and thawed plasma after prolonged exposure to 13.56-MHz radio energy.

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    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03534.x

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    authors: Bryant NJ,Shanahan LS,Sutton DM

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    pub_type: 杂志文章

    doi:10.1111/trf.16112

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  • Implementing mass-scale red cell genotyping at a blood center.

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    doi:10.1111/trf.13168

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  • Vancomycin-induced red cell aggregation.

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    pub_type: 杂志文章

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    authors: Evans CS,Tobler L,Polito A,Stewart J,Chien D,Wilber J,Quan S,Delaney S,Kuo G,Busch MP

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    journal_title:Transfusion

    pub_type: 杂志文章

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    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2012.03840.x

    authors: de Almeida-Neto C,Sabino EC,Liu J,Blatyta PF,Mendrone-Junior A,Salles NA,Leão SC,Wright DJ,Basques FV,Ferreira JE,Busch MP,Murphy EL,NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component.

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    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.14185

    authors: Rabik CA,Atkinson MA,Sule S,Strouse JJ

    更新日期:2017-09-01 00:00:00