Abstract：
CONTENT:Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disorder that affects genetically predisposed individuals. It manifests in susceptible individuals in response to exposure to Inhalant anesthetics, depolarizing muscle relaxants or extreme physical activity in hot environments. During exposure to these triggering agents, there is a rapid and sustained increase of myoplasmic calcium (Ca(2+)) concentration induced by hyperactivation of ryanodine receptor of skeletal muscle (RyR1), causing a profound change in Ca(2+) homeostasis, featuring a hypermetabolic state. RyR1, Ca(2+) release channels of sarcoplasmic reticulum, is the primary locus for MH susceptibility. Several mutations in the gene encoding the protein RyR1 have been identified; however, other genes may be involved. Actually, the standard method for diagnosing MH susceptibility is the muscle contracture test for exposure to halothane-caffeine (CHCT) and the only treatment is the use of dantrolene. However, with advances in molecular genetics, a full understanding of the disease etiology may be provided, favoring the development of an accurate diagnosis, less invasive, with DNA test, and also will provide the development of new therapeutic strategies for treatment of MH. Thus, this brief review aims to integrate molecular and clinical aspects of MH, gathering input for a better understanding of this channelopathy.
journal_name
Rev Bras Anestesioljournal_title
Revista brasileira de anestesiologiaauthors
Correia AC,Silva PC,da Silva BAdoi
10.1016/S0034-7094(12)70182-4subject
Has Abstractpub_date
2012-11-01 00:00:00pages
820-37issue
6eissn
0034-7094issn
1806-907Xpii
S0034-7094(12)70182-4journal_volume
62pub_type
杂志文章,评审abstract：BACKGROUND AND OBJECTIVES:Due to the high incidence of systemic hypertension and the lack of consensus on pressure levels to be accepted before inducing anesthesia for elective procedures, literature associated to hypertension and anesthesia was reviewed. Considering that canceling a surgery implies expenses making Med...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942005000500014
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Although acute and chronic pain are usually controlled with pharmacological interventions, 14 complementary methods of adjuvant and alternative analgesia (AAA) may reduce the abusive prescription of analgesics and the side effects that eventually compromise the patient's physiological status. ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942006000500012
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:There are no statistical data on the use of neuromuscular blockers in Brazil. This study aimed at statistically analyzing this topic. METHODS:Our study has compiled 831 answers to a questionnaire filled by anesthesiologists attending the 48th Brazilian Congress of Anesthesiology in Recife, 20...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942004000600016
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The analgesic effect of intraperitoneal administration of local anesthetics after laparoscopic cholecystectomy is a controversial issue, and the results described vary from considerable pain relief to little reduction in pain. The objective of this study was to evaluate the efficacy of the int...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942007000400002
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Different oxygenation techniques aim at promoting denitrogenation before apnea during induction. The main reason why CIO2 = 100% cannot be reached is the lack of adequate face mask coupling, allowing the entry of room air. Although anesthesiologists know this principle, not all of them apply i...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942005000500004
更新日期：2005-10-01 00:00:00
abstract：:The use of analgesia techniques for labor has become increasingly frequent, with neuraxial techniques being the most commonly used and most effective. Labor pain entails a number of physiological consequences that may be negative for the mother and fetus, and therefore must be treated. This literature review was perfo...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章,评审
doi：10.1016/j.bjan.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The discontinuation of drugs such as angiotensin-converting enzyme inhibitors (ACE inhibitors) has been suggested based on reports of hypotension during anesthesia. This may imply on a higher risk of intraoperative hypertensive peaks with deleterious consequences for the patient. The objective...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Ischemia-reperfusion injury is one of the consequences of tourniquet application for extremity surgery. The aim of the study was to establish the effect of dexmedetomidine on the acute lung injury following lower extremity experimental ischemia-reperfusion model in rats. METHODS:Twenty-eight Wistar-Albino bree...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2016.09.004
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the effects of spinal anesthesia using two different doses of fentanyl combined with low-dose levobupivacaine in anorectal surgery. METHODS:In this prospective, double-blind study, 52 American Society of Anaesthesiologists I-II patients scheduled for elective anorect...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2014.01.007
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Clinical trials with local anesthetic levo-enantiomers have shown higher safety due to lower cardiotoxicity. This study aimed at evaluating quality of anesthesia and maternal/fetal repercussions of 0.5% bupivacaine, enantiomeric 0.5% bupivacaine (S75-R25) and 0.75% ropivacaine, all associated ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942003000200005
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Systemic arterial hypertension affects approximately 20% of the world population, depending on the interaction between genetic predisposition and environmental factors. Stresses inherent to the anesthesiologists work might reflect in the cardiovascular system, influencing professionals blood p...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942002000500010
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Neuromuscular blockers (NMB) have been used for more than half of a century in anesthesia and have always been a challenge for anesthesiologists. Until recently, the reversal of nondepolarizing neuromuscular blockers had only one option: the use of anticholinesterase agents. However, in some s...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/S0034-7094(12)70153-8
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Anesthesiologists have traditionally developed and mastered regional anesthetic techniques over the years. To help treating chronic pain, they need to transfer acquired know-how in addition to surgical indications, recommending procedures at the right time in a multidisciplinary approach. This...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942003000500013
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:There are several approaches to the brachial plexus depending on the experience of the anesthesiologist and the site of the surgery. Posterior brachial plexus block may be an alternative for shoulder, clavicle and proximal humerus surgery. This study aims at presenting the results of patients ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942005000400006
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Postoperative delirium and postoperative cognitive dysfunction are some of the most common complications in older surgical patients and are associated with adverse outcomes. The aim of this study was to evaluate portuguese anesthesiologists' perspectives and knowledge about adverse postoperati...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2018.02.009
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:One-lung ventilation and selective intubation in neonates can be challenging due to intrinsic physiological specificities and material available. Ultrasound (US) is being increasingly used in many extents of anaesthesiology including confirmation of endotracheal tube position. CASE REPORT:We ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2019.06.014
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:A prospective, randomized and double-blind study was planned to identify the optimum dose of esmolol infusion to suppress the increase in bispectral index values and the movement and hemodynamic responses to tracheal intubation. MATERIALS AND METHODS:120 patients were randomly allocated to one of three group...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2013.09.008
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Klippel-Trenaunay syndrome is a rare congenital vascular disease characterized by cutaneous hemangiomas, varicosities, and limb asymmetry, which may evolve with coagulation disorders and hemorrhage as those more frequent complications in pregnant patients. Pregnancy is not advised in women with this syndro...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2018.01.015
更新日期：2018-01-01 00:00:00
abstract：:Dexmedetomidine is a highly selective α-2 agonist which has recently revolutionized our anesthesia and intensive care practice. An obstetric patient presented for emergency cesarean delivery under general anesthesia, with pre-eclampsia and postpartum hemorrhage. In carefully selected cases with refractory hypertension...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2015.09.001
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:The i-gel™ is one of the second generation supraglottic airway devices. Our study was designed to compare the i-gel and the Laryngeal Mask Airway Classic™ with respect to the clinical performance. METHODS:We compared the performance of the i-gel with that of the Laryngeal Mask Airway Classic in 120 patients un...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2014.02.009
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:The primary purpose of this study was to compare the effect of high fidelity simulation versus a computer-based case solving self-study, in skills acquisition about malignant hyperthermia on first year anesthesiology residents. METHODS:After institutional ethical committee approval, 31 first year anesthes...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2018.01.005
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The relationship between altered blood glucose levels and perioperative complications in elderly patients undergoing surgeries are not known. The objective of this study was to evaluate the association between fasting blood glucose levels and perioperative morbimortality in elderly surgical pa...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942007000600006
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Residual postoperative paralysis impairs airway patency increasing the risk for postoperative complications. Anti-cholinesterase agents improve neuromuscular transmission by acetylcholine build up in the endplate. However, when there is no longer neostigmine effect, 'recurarization' is theoret...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1590/s0034-70942004000400008
更新日期：2004-08-01 00:00:00
abstract：:The ex utero intrapartum treatment (EXIT) procedure consists of partial externalization of the fetus from the uterine cavity during delivery, allowing the maintenance of placental circulation. It is indicated in the presence of congenital malformation when difficulty in fetal airway access is anticipated, allowing it ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2015.08.001
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Urinary retention is a common condition in the post-anesthetic care unit (PACU). Vesical overdistension and consequent damage of the detrusor muscle of the urinary bladder represent situations that can be prevented. The ultrasound allows the reliable measurement of the urinary volume, determin...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/S0034-7094(10)70047-7
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Sevoflurane is an inhalational agent of choice in paediatric anaesthesia. For management of airways in children a suitable alternative to ETT is a paediatric proseal laryngeal mask airway (benchmark second generation SAD). Various studies have shown that less sevoflurane concentration is required for LMA ins...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2014.07.012
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The perioperative cardiac arrest (CA) and mortality rates in Brazil, a developing country, are higher than in developed countries. The hypothesis of this review was that knowledge of the epidemiology of perioperative CA and mortality in Brazil enables the comparison with developed countries. T...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章,评审
doi：10.1016/j.bjan.2020.02.004
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Ketamine S(+) is important in pain modulation in surgical patients. The objective of the present study was to evaluate the relationship between the levels of sedation produced by low doses of ketamine S(+), as well as encephalographic variables: BIS, SEF 95%, pEMG, suppression rate, and presen...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章,随机对照试验
doi：10.1016/S0034-7094(11)70036-8
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Tramadol hydrochloride is a centrally-acting synthetic opioid analgesic binding to specific opioid receptors. It is used in the management of chronic pain and is recommended as first line drug in the treatment of postoperative or orthopedic injury induced acute pain. The present work is design...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2016.10.006
更新日期：2017-01-01 00:00:00
abstract：:Electrosurgery is a technology developed over the last few years and has become a very important tool in modern surgery. Most of the equipment is considered safe, although there are risks related to its use. Several lesions may be caused by electrocautery, and burns are the most common and feared. We report two cases ...
journal_title：Revista brasileira de anestesiologia
pub_type： 杂志文章
doi：10.1016/j.bjan.2016.03.003
更新日期：2017-01-01 00:00:00
