Abstract:
OBJECTIVE:A prospective, randomized and double-blind study was planned to identify the optimum dose of esmolol infusion to suppress the increase in bispectral index values and the movement and hemodynamic responses to tracheal intubation. MATERIALS AND METHODS:120 patients were randomly allocated to one of three groups in a double-blind fashion. 2.5mgkg(-1) propofol was administered for anesthesia induction. After loss of consciousness, and before administration of 0.6mgkg(-1) rocuronium, a tourniquet was applied to one arm and inflated to 50mmHg greater than systolic pressure. The patients were divided into 3 groups; 1mgkg(-1)h(-1) esmolol was given as the loading dose and in Group Es50 50μgkg(-1)min(-1), in Group Es150 150μgkg(-1)min(-1), and in Group Es250 250μgkg(-1)min(-1) esmolol infusion was started. Five minutes after the esmolol has been begun, the trachea was intubated; gross movement within the first minute after orotracheal intubation was recorded. RESULTS:Incidence of movement response and the ΔBIS max values were comparable in Group Es250 and Group Es150, but these values were significantly higher in Group Es50 than in the other two groups. In all three groups in the 1st minute after tracheal intubation heart rate and mean arterial pressure were significantly higher compared to values from before intubation (p<0.05). In the study period there was no significant difference between the groups in terms of heart rate and mean arterial pressure. CONCLUSION:In clinical practise we believe that after 1mgkg(-1) loading dose, 150μgkg(-1)min(-1) iv esmolol dose is sufficient to suppress responses to tracheal intubation without increasing side effects.
journal_name
Rev Bras Anestesioljournal_title
Revista brasileira de anestesiologiaauthors
Cakırgöz MY,Taşdöğen A,Olguner C,Korkmaz H,Oğün E,Küçükebe B,Duran Edoi
10.1016/j.bjan.2013.09.008subject
Has Abstractpub_date
2014-11-01 00:00:00pages
425-32issue
6eissn
0034-7094issn
1806-907Xpii
S0034-7094(13)00117-7journal_volume
64pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The discontinuation of drugs such as angiotensin-converting enzyme inhibitors (ACE inhibitors) has been suggested based on reports of hypotension during anesthesia. This may imply on a higher risk of intraoperative hypertensive peaks with deleterious consequences for the patient. The objective...
journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
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journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942004000500002
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journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00