Abstract:
BACKGROUND AND OBJECTIVES:Perioperative myocardial ischemia is commonly observed, and it can increase significantly postoperative morbidity and mortality. The cardioprotective properties of volatile anesthetics and opioids have been studied during several decades and currently constitute powerful tools in the management of patients with ischemic coronariopathy. The objective of this review was to provide the fundaments of myocardial protection by preconditioning. CONTENTS:The concepts of cellular damage secondary to ischemia and reperfusion, ischemic preconditioning (IPC), and anesthetic preconditioning (APC), as well as the mechanisms of myocardial protection, are discussed. Recent studies in cardiac surgery demonstrated that the use of short periods of ischemia during reperfusion can reduce the area of myocardial infarction. Volatile anesthetic can also have a protective effect in myocardial reperfusion. Independently of the signaling pathway that leads to preconditioning, both anesthetic and ischemic, mitochondrial dependent KATP channels are considered the final mediators of cardioprotection by controlling the mitochondrial influx of calcium and, therefore, preventing the induction of necrosis and apoptosis. Although IPC and APC effectively reduce the area of myocardial infarction and improve postoperative ventricular function, it is important to stress that those treatments should be instituted before ischemic events to justify their clinical applicability. CONCLUSIONS:Phenomena known as myocardial ischemic preconditioning and anesthetic preconditioning are well known, and the mechanism of protection is similar in both situations; however, not every step that leads to this protection has been fully explained. Further studies are necessary to increase the clinical applicability of the cardioprotective properties of anesthetics.
journal_name
Rev Bras Anestesioljournal_title
Revista brasileira de anestesiologiaauthors
Pasqualin RC,Auler JO Jrdoi
10.1590/s0034-70942008000500009subject
Has Abstractpub_date
2008-09-01 00:00:00pages
512-9, 506-12issue
5eissn
0034-7094issn
1806-907Xpii
S0034-70942008000500009journal_volume
58pub_type
杂志文章,评审abstract:PURPOSE:The i-gel™ is one of the second generation supraglottic airway devices. Our study was designed to compare the i-gel and the Laryngeal Mask Airway Classic™ with respect to the clinical performance. METHODS:We compared the performance of the i-gel with that of the Laryngeal Mask Airway Classic in 120 patients un...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2014.02.009
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Magnesium is predominantly an intracellular ion. Its blocking effects on NMDA receptors are responsible for the analgesic and sedative characteristics of this ion. The objective of this study was to review the physiology, pharmacology, and decreased plasma levels of magnesium, as well as its a...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/s0034-7094(10)70013-1
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Respiratory dysfunction is common in children with acyanotic congenital heart defects (ACHD) with pulmonary hyperflow; however, little is known about the pulmonary structure of those patients. The objective of this study was to quantify the volumes of air and tissue, as well as the distributio...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/s0034-7094(09)70079-0
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although acute and chronic pain are usually controlled with pharmacological interventions, 14 complementary methods of adjuvant and alternative analgesia (AAA) may reduce the abusive prescription of analgesics and the side effects that eventually compromise the patient's physiological status. ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942006000500012
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Sedative and analgesic treatment administered to critically ill patients need to be regularly assessed to ensure that previously stated goals are well achieved as the risk of complications of oversedation is minimized. We revised and prospectively tested the Ramsay Sedation Scale (RSS) for int...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2017.03.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Several studies were performed with bupivacaine isomers in the attempt to find a safer drug than racemic bupivacaine. This study aimed at evaluating the efficacy of 0.5% bupivacaine enantiomeric mixture (MEE50%) as compared to 0.5% racemic bupivacaine in brachial plexus block for upper limb or...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000200003
更新日期:2005-04-01 00:00:00
abstract::We presented a 39-year-old female patient with life-threatening hypoxemia after tricuspid valve replacement because of Ebstein's anomaly. And the severe cyanosis is due to bioprosthetic valve stenosis and atrial septal defect. Anesthetic management of a patient with severe obstructive prosthetic valve dysfunction can ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2018.06.010
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Due to the high incidence of systemic hypertension and the lack of consensus on pressure levels to be accepted before inducing anesthesia for elective procedures, literature associated to hypertension and anesthesia was reviewed. Considering that canceling a surgery implies expenses making Med...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000500014
更新日期:2005-10-01 00:00:00
abstract::Since the beginning of the COVID-19 pandemic, many questions have come up regarding safe anesthesia management of patients with the disease. Regional anesthesia, whether peripheral nerve or neuraxial, is a safe alternative for managing patients with COVID-19, by choosing modalities that mitigate pulmonary function inv...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/j.bjan.2020.05.002
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Postanesthetic Delirium (PAD) is a common acute mental disorder most commonly developed in elderly patients. Its pathophysiology is poorly understood and PAD is often confused with others psychiatric disorders. This study aimed at reviewing important features of this anesthetic complication in...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942002000200013
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Different oxygenation techniques aim at promoting denitrogenation before apnea during induction. The main reason why CIO2 = 100% cannot be reached is the lack of adequate face mask coupling, allowing the entry of room air. Although anesthesiologists know this principle, not all of them apply i...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000500004
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Clinical trials with local anesthetic levo-enantiomers have shown higher safety due to lower cardiotoxicity. This study aimed at evaluating quality of anesthesia and maternal/fetal repercussions of 0.5% bupivacaine, enantiomeric 0.5% bupivacaine (S75-R25) and 0.75% ropivacaine, all associated ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942003000200005
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Some studies showed that ketamine inhibits the production of cytokines. The objective of this study was to evaluate the preemptive analgesic effect of epidural S(+)-ketamine in hysterectomy and plasmatic cytokines (IL-6, TNF-α and IL-10). METHOD:A double-blinded study with 29 patients was con...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,随机对照试验
doi:10.1016/S0034-7094(12)70097-1
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Neuromuscular blockers (NMB) have been used for more than half of a century in anesthesia and have always been a challenge for anesthesiologists. Until recently, the reversal of nondepolarizing neuromuscular blockers had only one option: the use of anticholinesterase agents. However, in some s...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/S0034-7094(12)70153-8
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Porphyrias represent a group of inherited or acquired disorders that involve enzymes that participate in heme synthesis. Acute manifestations affect the nervous system resulting in abdominal pain, vomiting, acute neuropathy, seizures, and mental disorders. The physiopathogeny results from the ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/S0034-7094(10)70079-9
更新日期:2010-11-01 00:00:00
abstract::Female, 85 y.o., weighting 60kg, multiple trauma patient. After an initial laparotomy, an emergent thoracotomy was performed using a bronchial blocker for lung isolation (initial active suction was applied). During surgery, bronchial cuff was deflated, causing a self-limited tracheal blood flooding. A second lung isol...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2017.09.004
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The SAPS 3 (Simplified Acute Physiology Score 3) prognostic system is composed of 20 parameters, represented by an acute physiology score and assessment of the previous status, aimed at establishing a predictive mortality index for patients admitted to intensive care units (ICU). The objective...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Dexmedetomidine is a highly selective α-2 agonist which has recently revolutionized our anesthesia and intensive care practice. An obstetric patient presented for emergency cesarean delivery under general anesthesia, with pre-eclampsia and postpartum hemorrhage. In carefully selected cases with refractory hypertension...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2015.09.001
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration. OBJECTIVE:The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia. DESIGN:Prospective, randomized, placebo controlled, double blin...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2016.01.003
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Costoclavicular brachial plexus block is an anesthesia performed through the infraclavicular route described in the literature as a safe and effective route for upper limb anesthesia distal to the elbow. The following report describes the case of a patient whose traditional plexus blocking tec...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2019.01.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The objective of this report was to show the importance of pre-anesthetic assessment in reducing morbidity and mortality of surgical patients and alert to problems and anesthetic care associated with obstructive sleep apnea. CASE REPORT:This is a 28-year old male patient with class II obesity...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/S0034-7094(11)70088-5
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The inadequate use of basic statistics is the main responsible for scientific article misinterpretation. The purpose of this review article was to review some basic statistical topics to alert authors and readers about the importance of basic statistics proper reporting. CONTENT:A bibliographi...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/j.bjan.2017.01.003
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Postoperative delirium and postoperative cognitive dysfunction are some of the most common complications in older surgical patients and are associated with adverse outcomes. The aim of this study was to evaluate portuguese anesthesiologists' perspectives and knowledge about adverse postoperati...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2018.02.009
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Tremors can be an adverse effect of the surgical intervention and anesthesia. The incidence of postoperative tremors varies from 6.3% to 66%. Young age, male gender, the use of halogenated anesthetics, and prolonged anesthesia or surgical procedure are related with tremors. Tremors are involun...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942007000400012
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In this study, we aimed to investigate the effects of sevoflurane, desflurane and propofol maintenances on serum levels of selenium, copper, zinc, iron, malondialdehyde, and glutathion peroxidase measurements, and antioxidant capacity. METHODS:60 patients scheduled for unilateral lower extrem...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2014.04.001
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The analgesic effect of intraperitoneal administration of local anesthetics after laparoscopic cholecystectomy is a controversial issue, and the results described vary from considerable pain relief to little reduction in pain. The objective of this study was to evaluate the efficacy of the int...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942007000400002
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Minimum anesthetic volume (MAV) of local anesthetics corresponds to the effective volume for regional anesthesia in 50% of patients. In this study, MAV of 0.5% racemic bupivacaine, 0.5% levobupivacaine and enantiomeric S75/R25 bupivacaine were calculated and compared. METHODS:This study invol...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000300002
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The relationship between altered blood glucose levels and perioperative complications in elderly patients undergoing surgeries are not known. The objective of this study was to evaluate the association between fasting blood glucose levels and perioperative morbimortality in elderly surgical pa...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942007000600006
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Univentricular heart is a complex, rare, and severe cardiopathy, with no possibility of curative surgical treatment, associated with a high mortality in the first years of life. The objective of this article was to describe a rare case of an adult patient with uncorrected single ventricle who ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942008000300007
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Since the beginning, soda lime use has presented some complications which resulted in its difficult application. However major advantages such as decreasing fresh gas flow, anesthetic consumption and operating room pollution, and improving breathing system and airway humidity, have pushed rese...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942004000300015
更新日期:2004-06-01 00:00:00