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[Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study].

Abstract：

BACKGROUND:Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration. OBJECTIVE:The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia. DESIGN:Prospective, randomized, placebo controlled, double blinded study. MATERIALS AND METHODS:Patients of both genders undergoing elective spine surgery were randomly assigned to two groups. Patients in Group P (pregabalin group) received 150mg of pregabalin orally 1h prior to induction of anesthesia with sips of water and patients in Group C (control group) received placebo. Anesthesia was induced with fentanyl 1.5mcg/kg, propofol 1.5-2.0mg/kg followed by succinylcholine 1.5mg/kg. The intensity of fasciculations was assessed by an observer blinded to the group allotment of the patient on a 4-point scale. A blinded observer recorded postoperative myalgia grade after 24h of surgery. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief. RESULTS:Demographic data of both groups were comparable (p>0.05). The incidence of muscle fasciculation's was not significant between two groups (p=0.707), while more patients in group C had moderate to severe fasciculation's compared to group P (p=0.028). The incidence and severity of myalgia were significantly lower in group P (p<0.05). CONCLUSION:Pregabalin 150mg prevents succinylcholine-induced fasciculations and myalgia and also decreases the fentanyl consumption in elective sine surgery.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Srivastava VK,Agrawal S,Nimbhorkar VK,Mishra A,Sharma S,Panda PK

doi

10.1016/j.bjan.2016.01.003

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

165-70

issue

2

eissn

0034-7094

issn

1806-907X

pii

S0034-7094(16)00005-2

journal_volume

66

pub_type

杂志文章

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