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50% enantiomeric excess hyperbaric bupivacaine (S75:R25) for infraumbilical surgeries. Study with different volumes.

Abstract：

BACKGROUND AND OBJECTIVES:Hyperbaric bupivacaine is commercially available in its racemic form. In Brazil, 50% enantiomeric excess bupivacaine (S75:R25) was introduced as an isobaric presentation. The objective of this study was to evaluate different volumes of hyperbaric S75:R25 bupivacaine in spinal blocks for infraumbilical surgeries. METHODS:Forty patients, ages 20 to 60 years, physical status ASA I and II, scheduled for infraumbilical surgeries under spinal block participated in this study. Patients were randomly divided in four groups of 10 patients: Group 2.5--received 2.5 ml of the solution (10 mg), Group 3--3 ml (12 mg), Group 4--4 ml (16 mg), and Group 5--5 ml (20 mg). The following parameters were evaluated and compared: latency, cephalad dispersion, motor blockade, cardiovascular changes, and neurologic complications. RESULTS:The study showed a latency of 1:33 +/- 0:26 (min:sec) without significant differences among the different doses. Motor blockade was dose-dependent. The incidence of bradycardia or hypotension was related with the increase in the dose. Anesthetic failures were not observed. CONCLUSIONS:0.4% hyperbaric 50% enantiomeric excess bupivacaine (S75:R25) with D5W provided fast onset of the blockade and the level of sensitive and motor blockades as well as the duration of the blockade were dose-dependent.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Imbelloni LE,Cordeiro JA

doi

10.1590/s0034-70942009000100002

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

3-10

issue

1

eissn

0034-7094

issn

1806-907X

pii

S0034-70942009000100002

journal_volume

59

pub_type

杂志文章,随机对照试验

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