Abstract:
INTRODUCTION:Hepatic ischemia-reperfusion injury is a common pathophysiological process in liver surgery. Whether Propofol can reduce myocardial ischemia-reperfusion injury induced by hepatic ischemia-reperfusion injury in rats, together with related mechanisms, still needs further studies. OBJECTIVE:To investigate if propofol would protect the myocardial cells from apoptosis with hepatic ischemia-reperfusion injury. METHODS:Male Sprague-Dawley rats (n=18) were randomly allocated into three groups: Sham Group (Group S, n=6), Hepatic Ischemia-reperfusion Injury Group (Group IR, n=6) and Propofol Group (Group P, n=6). Group S was only subjected to laparotomy. Group IR was attained by ischemia for 30min and reperfusion for 4h. Group P was subjected identical insult as in Group IR with the administration of propofol started 10min before ischemia with 120mg.kg-1, following by continuous infusion at 20mg.kg-1.h-1. Cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay. Endoplasmic reticulum Ca2+-ATPase2 (SERCA2) and cysteine-containing aspartic acid cleaved-caspase3 (cleaved-caspase3) were assayed by western blot and Altimeter polymerase chain reaction. RESULTS:Apoptosis rate was increased, with mRNA and protein of SERCA2 down-regulated and cleaved-caspase3 up-regulated in Group IR compared with Group S (p<0.01). Apoptosis rate was decreased, with mRNA and protein of SERCA2 up-regulated and cleaved-caspase3 down-regulated in Group P compared with Group IR (p<0.01). CONCLUSIONS:Propofol can reduce hepatic ischemia-reperfusion injury-induced myocardial cell apoptosis, meanwhile, can up-regulate mRNA and protein of SERCA2 in rats.
journal_name
Rev Bras Anestesioljournal_title
Revista brasileira de anestesiologiaauthors
Yu S,Guo Y,Zhang W,Zheng L,Ren J,Jin J,Yu B,Zhang Y,Wang H,Zhang Ydoi
10.1016/j.bjan.2018.06.003subject
Has Abstractpub_date
2018-01-01 00:00:00pages
591-596issue
6eissn
0034-7094issn
1806-907Xpii
S0034-7094(16)30177-5journal_volume
68pub_type
杂志文章abstract::The use of analgesia techniques for labor has become increasingly frequent, with neuraxial techniques being the most commonly used and most effective. Labor pain entails a number of physiological consequences that may be negative for the mother and fetus, and therefore must be treated. This literature review was perfo...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/j.bjan.2018.12.001
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Several studies were performed with bupivacaine isomers in the attempt to find a safer drug than racemic bupivacaine. This study aimed at evaluating the efficacy of 0.5% bupivacaine enantiomeric mixture (MEE50%) as compared to 0.5% racemic bupivacaine in brachial plexus block for upper limb or...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000200003
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Combined spinal-epidural (CSE) has become an increasingly popular alternative to traditional labour epidural due to its rapid onset and reliable analgesia provided. This was a prospective, convenient sampling study to determine the effects of CSE analgesia on labour outcome. METHODS:One hundr...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2014.09.009
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Postoperative dysphonia is commonly associated to tracheal intubation and extubation complications, but other causal factors may be involved, including surgical procedures. This article aimed at reporting a late postoperative dysphonia as a consequence of left vocal cord paralysis secondary to...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Porphyrias represent a group of inherited or acquired disorders that involve enzymes that participate in heme synthesis. Acute manifestations affect the nervous system resulting in abdominal pain, vomiting, acute neuropathy, seizures, and mental disorders. The physiopathogeny results from the ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/S0034-7094(10)70079-9
更新日期:2010-11-01 00:00:00
abstract::Dexmedetomidine is a highly selective α-2 agonist which has recently revolutionized our anesthesia and intensive care practice. An obstetric patient presented for emergency cesarean delivery under general anesthesia, with pre-eclampsia and postpartum hemorrhage. In carefully selected cases with refractory hypertension...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2015.09.001
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Postanesthetic Delirium (PAD) is a common acute mental disorder most commonly developed in elderly patients. Its pathophysiology is poorly understood and PAD is often confused with others psychiatric disorders. This study aimed at reviewing important features of this anesthetic complication in...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942002000200013
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The adequate maintenance of inhaled gases temperature during anesthetic procedures is critical to prevent perioperative respiratory complications. This study aimed at comparing the ability to warm up inhaled gases of coaxial breathing system and conventional system, by varying fresh gas flows ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942005000100008
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Magnesium is predominantly an intracellular ion. Its blocking effects on NMDA receptors are responsible for the analgesic and sedative characteristics of this ion. The objective of this study was to review the physiology, pharmacology, and decreased plasma levels of magnesium, as well as its a...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/s0034-7094(10)70013-1
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Dural arteriovenous fistulas are anomalous shunts between dural arterial and venous channels whose nidus is located between the dural leaflets. For those circumstances when invasive treatment is mandatory, endovascular techniques have grown to become the mainstay of practice, choice attributab...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2016.09.002
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Intracranial subdural hematoma is a rare complication following spinal anesthesia. The diagnosis is usually difficult because initial symptoms are the same of post-dural puncture headache. The objective was to report a case of early diagnosed subdural hematoma after spinal anesthesia performed...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/S0034-7094(12)70107-1
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Problems with pediatric airways are among the greatest challenges an anesthesiologist can face. Laryngeal spasm, which is twice or three times more frequent in the pediatric population, is paramount. The objective of this work was to report the treatment of laryngeal spasm applying digital pre...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942008000600008
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:One-lung ventilation and selective intubation in neonates can be challenging due to intrinsic physiological specificities and material available. Ultrasound (US) is being increasingly used in many extents of anaesthesiology including confirmation of endotracheal tube position. CASE REPORT:We ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2019.06.014
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Costoclavicular brachial plexus block is an anesthesia performed through the infraclavicular route described in the literature as a safe and effective route for upper limb anesthesia distal to the elbow. The following report describes the case of a patient whose traditional plexus blocking tec...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2019.01.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Sedative and analgesic treatment administered to critically ill patients need to be regularly assessed to ensure that previously stated goals are well achieved as the risk of complications of oversedation is minimized. We revised and prospectively tested the Ramsay Sedation Scale (RSS) for int...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2017.03.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effects of spinal anesthesia using two different doses of fentanyl combined with low-dose levobupivacaine in anorectal surgery. METHODS:In this prospective, double-blind study, 52 American Society of Anaesthesiologists I-II patients scheduled for elective anorect...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2014.01.007
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Smoking is becoming very important for anesthetic morbidity. In spite of its widespread noxious effects on health, developing countries have increasing statistics on smoking population. This review aimed at showing action mechanisms and effects of cigarettes on different organs and systems, an...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:During an awake craniotomy in which the Aachen Aphasia test is performed, it is necessary to use the 'asleep-awake-asleep' anesthetic technique. The objective of this case report was to describe the anesthetic technique used in a patient with signs of difficult airway. CASE REPORT:The case of...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942006000600010
更新日期:2006-12-01 00:00:00
abstract:INTRODUCTION:Blood is an important resource in several lifesaving interventions, such as anemia correction and improvement of oxygen transport capacity. Despite advances, packed red blood cell (PRBC) transfusion still involves risks. The aim of this study was to describe the knowledge of anesthesiologists about the ind...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2016.09.011
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Deep analgesia of burned patients needing daily care of their injuries is a field where references are very scarce in the literature. This study aimed at evaluating balneotherapy anesthetic technique in 2852 procedures. METHODS:A one-year period prospective evaluation was performed on sedativ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942004000200010
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The harmful effects of workplace noise pollution are well known and described in the literature. The effects of prolonged exposure to noise in areas demanding high level of concentration, such as operating rooms, depend on the variability of individual responses and intensity of different gene...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1016/S0034-7094(12)70123-X
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Respiratory dysfunction is common in children with acyanotic congenital heart defects (ACHD) with pulmonary hyperflow; however, little is known about the pulmonary structure of those patients. The objective of this study was to quantify the volumes of air and tissue, as well as the distributio...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/s0034-7094(09)70079-0
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Aortic flow suppression and release during aortic procedures promote major hemodynamic disorders. This study aimed at evaluating these disorders in dogs anesthetized with isoflurane or sevoflurane. METHODS:This study involved 41 dogs divided in two groups according to the anesthetic agent use...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1590/s0034-70942006000300004
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Trigeminocardiac reflex is a physiological phenomenon that may occur in head and neck surgery, and is usually benign. However, it may present with exaggerated responses with severe morbidity. CASE REPORT:Male patient, 26 years old, candidate for surgical treatment of zygomatic-orbital complex fracture. The ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2018.11.003
更新日期:2019-01-01 00:00:00
abstract::Electrosurgery is a technology developed over the last few years and has become a very important tool in modern surgery. Most of the equipment is considered safe, although there are risks related to its use. Several lesions may be caused by electrocautery, and burns are the most common and feared. We report two cases ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2016.03.003
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Several locoregional techniques have been described for the management of acute and chronic pain after breast surgery. The optimal technique should be easy to perform, reproducible, with little discomfort to the patient, little complications, allowing good control of acute pain and a decreased incidence of c...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2015.12.002
更新日期:2016-09-01 00:00:00
abstract::The ex utero intrapartum treatment (EXIT) procedure consists of partial externalization of the fetus from the uterine cavity during delivery, allowing the maintenance of placental circulation. It is indicated in the presence of congenital malformation when difficulty in fetal airway access is anticipated, allowing it ...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章
doi:10.1016/j.bjan.2015.08.001
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Hemicorporectomy progresses with hemodynamic and ventilatory repercussions that make anesthesia management definitive to patient outcome. OBJECTIVE:Report anesthesia approach for a patient with squamous cell carcinoma submitted to urgent hemicorporectomy after an episode of hypovolemic shock. CASE REPORT...
journal_title:Revista brasileira de anestesiologia
pub_type:
doi:10.1016/j.bjan.2019.12.011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Perioperative myocardial ischemia is commonly observed, and it can increase significantly postoperative morbidity and mortality. The cardioprotective properties of volatile anesthetics and opioids have been studied during several decades and currently constitute powerful tools in the managemen...
journal_title:Revista brasileira de anestesiologia
pub_type: 杂志文章,评审
doi:10.1590/s0034-70942008000500009
更新日期:2008-09-01 00:00:00
abstract::Through the Life Cycle of Intraoperative Transesophageal Echocardiography (ETTI/SBA) the Brazilian Society of Anesthesiology, together with the Department of Cardiovascular Image of the Brazilian Society of Cardiology (DIC/SBC), createded a task force to standardize the use of intraoperative transesophageal echocardio...
journal_title:Revista brasileira de anestesiologia
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1016/j.bjan.2017.07.004
更新日期:2018-01-01 00:00:00