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Comparison of the plasma levels of 50% enantiomeric excess (S75/R25) 0.5% bupivacaine combined with 1:200,000 epinephrine between the parasacral and infragluteal sciatic nerve blocks.

Abstract：

BACKGROUND AND OBJECTIVES:Local anesthetics (LA) are safe drugs when the proper dose and localization are used. The rate of absorption of the local anesthetic depends on its mass and blood flow at the site of the injection. The objective of this study was to analyze the plasma concentration of 50% enantiomeric excess (S75R25) 0.5% bupivacaine combined with 1:200,000 epinephrine in the parasacral (PS) and infragluteal (IG) sciatic nerve block (SNB). METHODS:Twenty-eight patients scheduled for ankle and foot surgeries were randomly divided into two groups in this prospective study. In Group 1, SNB was performed with IG neurostimulation, while in Group 2 the PS method was used. Both groups received 30 mL of 0.5% bupivacaine (S75/R25) with 1:200,000 epinephrine. Arterial blood samples, 5 mL, were drawn at 0, 15, 30, 60, and 90 minutes after the administration of the LA. High-performance liquid chromatography was used to analyze the serum concentrations. Demographic data of both groups were compared using the Student t test for independent samples and Fisher's Exact test. Bifactorial Analysis of Variance for repeated samples was used for the data concerning the plasma concentrations. RESULTS:Groups 1 and 2 showed no significant demographic differences. The maximal concentration (Cmax) in Group 1 (308 +/- 91 ng.mL(-1)) was obtained in samples number 5 (90 minutes), while in Group 2 (425 +/- 280 ng.mL(-1)) it was obtained in samples number 2 (15 minutes). Cases of systemic toxicity were not observed. CONCLUSIONS:Cmax of 0.5 % bupivacaine (S75/R25) with 1:200,000 in the parasacral approach was higher when compared with the infragluteal SNB.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Helayel PE,Bussman AR,da Conceição DB,de Oliveira Filho GR

doi

10.1590/s0034-70942008000400001

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

323-9

issue

eissn

0034-7094

issn

1806-907X

pii

S0034-70942008000400001

journal_volume

pub_type

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Comparison of the plasma levels of 50% enantiomeric excess (S75/R25) 0.5% bupivacaine combined with 1:200,000 epinephrine between the parasacral and infragluteal sciatic nerve blocks.