[Propofol infusion syndrome.].

Abstract:

BACKGROUND AND OBJECTIVES:Propofol infusion syndrome has been described as a rare, and frequently fatal, syndrome that occurs after prolonged infusion of this drug. It might result in severe metabolic acidosis, rhabdomyolysis, cardiovascular failure, and death. The objective of this report was to review the literature to present aspects related to the propofol infusion syndrome. CONTENTS:The physiopathology, clinical characteristics, and treatment, of the propofol infusion syndrome as well as dose recommendations for severely ill patients are presented here. CONCLUSIONS:Propofol should be used with caution when it is administered as continuous infusion for prolonged periods of time. The development of signs suggestive of the propofol infusion syndrome indicates the drug should be discontinued immediately and support measures instituted.

journal_name

Rev Bras Anestesiol

authors

Barbosa FT

doi

10.1590/s0034-70942007000500009

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

539-42

issue

5

eissn

0034-7094

issn

1806-907X

pii

S0034-70942007000500009

journal_volume

57

pub_type

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