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[The effect of pheniramine on fentanyl-induced cough: a randomized, double blinded, placebo controlled clinical study].

Abstract：

BACKGROUND AND OBJECTIVES:There are many studies conducted on reducing the frequency and severity of fentayl-induced cough during anesthesia induction. We propose that pheniramine maleate, an antihistaminic, may suppress this cough. We aim to observe the effect of pheniramine on fentanyl-induced cough during anesthesia induction. METHODS:This is a double-blinded, prospective, three-arm parallel, randomized clinical trial of 120 patients with ASA (American Society of Anesthesiologists) physical status III and IV who aged ≥18 and scheduled for elective open heart surgery during general anesthesia. Patients were randomly assigned to three groups of 40 patients, using computer-generated random numbers: placebo group, pheniramine group, and lidocaine group. RESULTS:Cough incidence differed significantly between groups. In the placebo group, 37.5% of patients had cough, whereas the frequency was significantly decreased in pheniramine group (5%) and lidocaine group (15%) (Fischer exact test, p=0.0007 and p=0.0188, respectively). There was no significant change in cough incidence between pheniramine group (5%) and lidocaine group (15%) (Fischer exact test, p=0.4325). Cough severity did also change between groups. Post Hoc tests with Bonferroni showed that mean cough severity in placebo differed significantly than that of pheniramine group and lidocaine group (p<0.0001 and p=0.009, respectively). There was no significant change in cough severity between pheniramine group and lidocaine group (p=0.856). CONCLUSION:Intravenous pheniramine is as effective as lidocaine in preventing fentayl-induced cough. Our results emphasize that pheniramine is a convenient drug to decrease this cough.

journal_name

Rev Bras Anestesiol

journal_title

Revista brasileira de anestesiologia

authors

Arslan Z,Çalık ES,Kaplan B,Ahiskalioglu EO

doi

10.1016/j.bjan.2015.10.005

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

383-7

issue

4

eissn

0034-7094

issn

1806-907X

pii

S0034-7094(15)00107-5

journal_volume

66

pub_type

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