Obesity and influenza associated mortality: evidence from an elderly cohort in Hong Kong.

Abstract:

OBJECTIVE:Obesity was not identified as a risk factor for influenza until the recent 2009 H1N1 pandemic. Based on a cohort of 66,820 subjects aged 65 years and over with the follow-up period from July 1998 to December 2010 in Hong Kong, we assessed the modifying effect of obesity on mortality risks specifically attributable to influenza infections (termed as "influenza associated mortality risks"). METHODS:A Cox proportional model with time dependent covariates was adopted to assess the hazard ratio of mortality in each obesity group when influenza activity increased 10% in the community. RESULTS:Hazard ratio of influenza-associated all-cause mortality was 1.081 (95% confidence interval 1.013, 1.154), 1.047 (1.012, 1.084), 0.981 (0.936, 1.028), 1.018 (0.980, 1.058) and 1.062 (0.972, 1.162) in the underweight, normal, overweight, moderate obesity and severe obesity groups, respectively. A similar U shape pattern across the obesity groups was also observed in influenza associated mortality risks of respiratory diseases, pneumonia and influenza. This pattern was more evident among ever smokers, although the influenza effect estimates in each obesity group had overlapping confidence intervals. CONCLUSION:There is some but limited evidence to suggest that underweight and obesity were associated with higher mortality risks of influenza in old population.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Yang L,Chan KP,Lee RS,Chan WM,Lai HK,Thach TQ,Chan KH,Lam TH,Peiris JS,Wong CM

doi

10.1016/j.ypmed.2012.11.017

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

118-23

issue

2

eissn

0091-7435

issn

1096-0260

pii

S0091-7435(12)00594-4

journal_volume

56

pub_type

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