A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer.

Abstract:

:Ernst Wynder did not believe that environmental tobacco smoke (ETS), also known as secondhand smoke, was a cause of lung cancer because his own data did not support this. His view on the issue may have begun to change with our initial studies, carried out at the American Health Foundation, showing that metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were present in the urine of non-smokers exposed to ETS. The metabolites - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Glucs) - have now emerged as leading biomarkers for the study of carcinogen exposure in non-smokers exposed to ETS. Subsequent work has consistently demonstrated elevated levels of NNAL plus NNAL-Glucs in the urine of people exposed to ETS in various field studies and throughout life. These studies strongly support the epidemiologic data demonstrating that ETS exposure causes lung cancer in non-smokers and have likely had an impact on tobacco control.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Hecht SS

doi

10.1016/j.ypmed.2006.07.020

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

256-60

issue

4

eissn

0091-7435

issn

1096-0260

pii

S0091-7435(06)00326-4

journal_volume

43

pub_type

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