Abstract:
OBJECTIVE:To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic. DESIGN:Phase I trial for an intracortical BCI integrated with forearm functional electrical stimulation (FES). Data reported span postimplant days 137 to 1478. SETTING:Tertiary care outpatient rehabilitation center. PARTICIPANT:A 27-year-old man with C5 class A (on the American Spinal Injury Association Impairment Scale) traumatic spinal cord injury INTERVENTIONS: After array implantation in his left (dominant) motor cortex, the participant trained with BCI-FES to control dynamic, coordinated forearm, wrist, and hand movements. MAIN OUTCOME MEASURES:Performance on standardized tests of arm motor ability (Graded Redefined Assessment of Strength, Sensibility, and Prehension [GRASSP], Action Research Arm Test [ARAT], Grasp and Release Test [GRT], Box and Block Test), grip myometry, and functional activity measures (Capabilities of Upper Extremity Test [CUE-T], Quadriplegia Index of Function-Short Form [QIF-SF], Spinal Cord Independence Measure-Self-Report [SCIM-SR]) with and without the BCI-FES. RESULTS:With BCI-FES, scores improved from baseline on the following: Grip force (2.9 kg); ARAT cup, cylinders, ball, bar, and blocks; GRT can, fork, peg, weight, and tape; GRASSP strength and prehension (unscrewing lids, pouring from a bottle, transferring pegs); and CUE-T wrist and hand skills. QIF-SF and SCIM-SR eating, grooming, and toileting activities were expected to improve with home use of BCI-FES. Pincer grips and mobility were unaffected. BCI-FES grip skills enabled the participant to play an adapted "Battleship" game and manipulate household objects. CONCLUSIONS:Using BCI-FES, the participant performed skillful and coordinated grasps and made clinically significant gains in tests of upper limb function. Practice generalized from training objects to household items and leisure activities. Motor ability improved for palmar, lateral, and tip-to-tip grips. The expects eventual home use to confer greater independence for activities of daily living, consistent with observed neurologic level gains from C5-6 to C7-T1. This marks a critical translational step toward clinical viability for BCI neuroprosthetics.
journal_name
Arch Phys Med Rehabiljournal_title
Archives of physical medicine and rehabilitationauthors
Bockbrader M,Annetta N,Friedenberg D,Schwemmer M,Skomrock N,Colachis S 4th,Zhang M,Bouton C,Rezai A,Sharma G,Mysiw WJdoi
10.1016/j.apmr.2018.07.445subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1201-1217issue
7eissn
0003-9993issn
1532-821Xpii
S0003-9993(19)30163-7journal_volume
100pub_type
杂志文章abstract::This was a controlled study of the efficacy of two forms of therapy on upper limb functions of hemiparetic patients--one heavily behavioral and the other based on Bobath therapeutic exercises. It arose from an earlier pilot study comparing EMG biofeedback with physical therapy from which it was concluded that both the...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To investigate the therapeutic effect of functional exercise augmented by programmable implanted microstimulators on arm and hand function. DESIGN:Before and after study. SETTING:Implantation was performed in a neurosurgery unit, systems were programmed, and tests were conducted in a university laboratory a...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2008.01.030
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To examine whether gait and postures can accurately be detected with a single small body-fixed device in patients with mild to moderate Parkinson's disease (PD). DESIGN:Results of a triaxial accelerometer-based method were evaluated against video observation scores (criterion measure). Study 1: Subjects perf...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2010.05.004
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:To compare the effects of biofeedback with those of active exercise and passive treatment in treating work-related neck and shoulder pain. DESIGN:A randomized controlled trial with 3 intervention groups and a control group. SETTING:Participants were recruited from outpatient physiotherapy clinics and a loc...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2010.12.037
更新日期:2011-06-01 00:00:00
abstract::Stroke frequently results in psychologic distress and activity limitations across multiple domains of functioning. However, most stroke outcome measurement tools and clinical trial endpoints are narrowly focused on neurologic symptom status and physical aspects of functioning, and rarely assess other important compone...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.36838
更新日期:2002-12-01 00:00:00
abstract::This investigation focuses on the effect of vocational rehabilitation on persons with chronic disabilities who have epilepsy, heart disease, spinal cord injury, arthritis, or emphysema. A thesis is proposed that such rehabilitants might be more vulnerable to unemployment than others, and it is also hypothesized that t...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract::Positive sharp waves occur in a variety of neurogenic, myogenic, and metabolic disorders. Although not synonymous with denervation, their presence is usually associated with some type of pathology. The authors found only one reported series of patients who had diffuse insertional positive waves but no demonstrable und...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVES:To estimate the test-retest and interrater reliability of the center of pressure-center of mass (COP-COM) variable of postural control in the elderly. DESIGN:The biomechanic variable COP-COM, which represents the distance between the COP and the COM, was determined from 2 AMTI force platforms and 3 OPTOTRAK...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2001.18678
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To provide a quantitative synthesis of randomized controlled trials (RCTs) examining the effect of exercise training on muscular and cardiorespiratory fitness in persons with multiple sclerosis (MS). DATA SOURCES:Three electronic databases, PubMed, Google Scholar, and Web of Science, were searched for all re...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.apmr.2016.01.023
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To identify determinants for the use of a walking device in persons with Parkinson's disease (PD). DESIGN:Cross-sectional study of participants with PD. SETTING:Laboratory. PARTICIPANTS:Persons with PD (N=85; 60 men) were studied. Their mean age was 69.4±8.9 years. The average time since diagnosis was 7.9±...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2014.06.002
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of combination cathodal transcranial direct current stimulation (tDCS) and virtual reality (VR) therapy for upper extremity (UE) training in patients with subacute stroke. DESIGN:Pilot randomized controlled trial. Patients were randomly assigned to 1 of 3 groups: group A received c...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2013.10.027
更新日期:2014-03-01 00:00:00
abstract::The axial rotation and simultaneous lateral flexion of the cervical spine is kinesiologically related to the movements of the upper thoracic spine. Five brachialgia patients were found to have a hypomobile first rib on the painful side in a cineradiographic study. The kinesiologic finding was the following: when the n...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The symptoms of urinary incontinence, ataxia, and mental confusion are an integral part of the clinical presentation of normal pressure hydrocephalus (NPH). They are also common presentations in the rehabilitation setting of patients who have had a cerebral vascular accident. The concurrence of these entities challeng...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(97)90069-1
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVES:To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. DESIGN:Prospective cohort study with 6 years of follow-up. SETTING:Two university research clinics. PARTICIPANTS:Community-dwelling older adults enrolled in the Health...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2015.08.423
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To predict the place of discharge or discharge Functional Independence Measure (FIM) score for stroke survivors with moderate disability using neural network modeling. Our previous work demonstrated that the FIM predicts the level of recovery for stroke survivors with either severe or mild disabilities. DESI...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(97)90222-7
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:To determine content validity of the Muscle Power Sprint Test (MPST), and construct validity and reliability of the MPST, 10×5 Meter Sprint Test (10×5MST), slalom test, and One Stroke Push Test (1SPT) in wheelchair-using youth with spina bifida (SB). DESIGN:Clinimetric study. SETTING:Rehabilitation centers...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2016.08.469
更新日期:2017-06-01 00:00:00
abstract:UNLABELLED:This self-directed learning module highlights approaches to the investigation of selected lumbar spine conditions. It is part of the chapter on chronic pain management in the Self-Directed Physiatric Education Program for practitioners in physical medicine and rehabilitation. The first objective explores the...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,评审
doi:10.1016/j.apmr.2007.12.008
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:To investigate environmental barriers reported by stroke survivors in the rural areas of China and to determine the impact of environmental barriers on activity and participation relative to demographic characteristics and body functioning. DESIGN:Cross-sectional survey. SETTING:Structured interviews in th...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2015.01.024
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To determine whether alternating frequency transcutaneous electric nerve stimulation (TENS) at 2 and 100Hz (2/100Hz) has a more potent hypoalgesic effect than a fixed frequency at 2 or 100Hz in healthy participants. DESIGN:A single-blind randomized controlled trial with a convenience sample. SETTING:Univers...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2007.07.017
更新日期:2007-10-01 00:00:00
abstract::The purpose of this study was to determine the reliability of isokinetic and isometric measurement of strength for tests of knee extension and hip abduction on men with mental retardation (MR). In addition, the relationships between isokinetic measures of peak torque (PT) and total work (TW) and isometric peak torque ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/0003-9993(93)90012-y
更新日期:1993-08-01 00:00:00
abstract::Recordings of pressure within the bladder, urethra, rectum, and external anal sphincter with image intensification and videotaping were carried out in spinal cord injury patients with complete and incomplete lesions, during spinal shock and in the chronic stage. The behavior of the external urethral sphincter and the ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::A patient underwent tracheo-esophageal anastomosis following repeated episodes of aspiration pneumonia after the resection of a meningioma at foramen magnum. The surgery eliminated the intractable problem with aspiration. This procedure is reversible, and restoration of the laryngeal function can be accomplished when ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract:OBJECTIVE:We investigated the treatment effects of a home-based rehabilitation program compared with clinic-based rehabilitation in patients with stroke. DESIGN:A single-blinded, 2-sequence, 2-period, crossover-designed study. SETTING:Rehabilitation clinics and participant's home environment. PARTICIPANTS:Individual...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2018.03.017
更新日期:2018-12-01 00:00:00
abstract::This essay complements the scientific and practice scope of the American Academy of Neurology Guideline on Disorders of Consciousness by providing a discussion of the ethical, palliative, and policy aspects of the management of this group of patients. We endorse the renaming of "permanent" vegetative state to "chronic...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2018.07.003
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effectiveness of neuromuscular electrical stimulation (NMES) with or without other interventions in improving lower limb activity after chronic stroke. DATA SOURCES:Electronic databases, including PubMed, EMBase, Cochrane Library, PEDro (Physiotherapy Evidence Database), and PsycINFO, were...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2017.12.019
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the joint-angle-dependent neuromuscular functions at the affected wrist in hemiplegic subjects after stroke while doing isometric maximal voluntary wrist flexion and extension across different wrist angles. DESIGN:We investigated torques during isometric maximal voluntary wrist flexions and exten...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2006.02.003
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To gain greater insight into the lived experience of individuals with spinal cord injury (SCI) and neurogenic bowel dysfunction (NBD). DESIGN:Qualitative (phenomenologic) interviews and analysis. SETTING:Community. PARTICIPANTS:Individuals with SCI and NBD (N=19) residing in the community. INTERVENTIONS:N...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2014.07.417
更新日期:2015-01-01 00:00:00
abstract::This study included patients who presented with at least one chronic nonhealing ulcer and had been told by their referring physician that they would require amputation at the transmetatarsal level or higher. Hospital records of all patients seen in a comprehensive wound-healing clinic from August 1984 through January ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:To assess the long-term efficacy of selective tibial neurotomy in the treatment of spastic equinovarus foot in hemiplegic patients. DESIGN:Intervention study (before-after trial) with an observational design and 2-year follow-up. SETTING:Spasticity group in a university hospital. PARTICIPANTS:Hemiplegic pa...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1016/j.apmr.2010.04.010
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of long-term Tai Chi practice on balance control when healthy elderly Tai Chi practitioners stood under reduced or conflicting somatosensory, visual, and vestibular conditions, as compared with healthy elderly non-Tai Chi practitioners and young subjects. DESIGN:Cross-sectional stu...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2003.02.002
更新日期:2004-01-01 00:00:00