Abstract：
:Psoralea corylifolia L. (Fabaceae) is a traditional Chinese medicine with many beneficial effects in medical therapies. Bakuchiol was the main active ingredient of Psoralea corylifolia L. In this study, a novel method of pre-column derivatization with dansyl chloride followed by analysis of ultra high-performance liquid chromatographic-tandem mass spectrometry (UHPLC-MS/MS) was established and validated for quantification of bakuchiol in rat plasma. The linearity of this approach was confirmed to be within the concentration range of 0.5-1000 ng/mL and the lower limit of quantification was at 0.5 ng/mL. The total analysis time was 1.5 min for each pretreated sample. Also, the precision, accuracy, stability, recovery and matrix effect of this method were proved to meet the requirements for bioanalysis. The intravenous and oral pharmacokinetic profiles of bakuchiol were obtained by utilizing this approach. The oral bioavailability of bakuchiol in rats (3.2%) was identified.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Zhuang X,Zhong Y,Yuan M,Li Hdoi
10.1016/j.jpba.2012.11.001subject
Has Abstractpub_date
2013-03-05 00:00:00pages
18-24eissn
0731-7085issn
1873-264Xpii
S0731-7085(12)00591-2journal_volume
75pub_type
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