Abstract：
:A selective method for the determination of sulphobutylether-beta-cyclodextrin (SBECD) in human plasma has been developed and validated over the range 4-200 microg ml(-1). SBECD is extracted from plasma using end-capped cyclohexyl solid phase extraction cartridges. This is followed by high performance size exclusion chromatography with a mobile phase consisting of 1-naphthol (0.1 mM) in methanol-potassium nitrate (0.2 M) (1:9 v/v), 1 ml min(-1). The high aqueous content of the mobile phase quenches the fluorescence of 1-naphthol. However, the naphthol forms an inclusion complex with SBECD. The non-polar 'bucket' environment of the inclusion region restores the fluorescence, which is measured at excitation and emission wavelengths of 290 and 360 nm, respectively, when SBECD elutes from the column.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Gage R,Venn RF,Bayliss MA,Edgington AM,Roffey SJ,Sorrell Bdoi
10.1016/s0731-7085(99)00283-6subject
Has Abstractpub_date
2000-06-01 00:00:00pages
773-80issue
5eissn
0731-7085issn
1873-264Xpii
S0731-7085(99)00283-6journal_volume
22pub_type
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