Abstract:
:In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox of SO(3)(2-) with Ce(IV) in acidic medium. Under the optimized conditions, the proposed method allows the measurement of metoprolol tartrate over the range of 1.5 x 10(-8) to 7.3 x 10(-6)mol/L with a detection limit of 4.7 x 10(-9)mol/L (3sigma), and the relative standard deviation for 7.3 x 10(-7)mol/L metoprolol tartrate (n=11) is 2.20%. The utility of this method was demonstrated by determining metoprolol tartrate in tablets and human urine sample.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Liu H,Ren J,Hao Y,Ding H,He P,Fang Ydoi
10.1016/j.jpba.2006.04.008subject
Has Abstractpub_date
2006-09-26 00:00:00pages
384-8issue
3eissn
0731-7085issn
1873-264Xpii
S0731-7085(06)00315-3journal_volume
42pub_type
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