Abstract:
:A new procedure for kinetic determination of paracetamol in pharmaceuticals is proposed. The method is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system being in a stable non-equilibrium stationary state close to the bifurcation point. In the case considered as the matrix system, the Bray-Liebhafsky oscillatory reaction is used. The response of the matrix system to the perturbations by different concentrations of paracetamol is followed by a Pt-electrode. Proposed method relies on the linear relationship between maximal potential shift, DeltaEm, and the logarithm of added paracetamol amounts. It is obtained in optimized experimental conditions for variable amounts of paracetamol in the range 0.0085 and 1.5 micromol. The sensitivity and precision of proposed method were quite good (0.0027 micromol as the limit of detection and 2.4% as R.S.D.). Some aspects of possible chemical interactions between paracetamol and matrix are discussed. Applicability of the proposed method to the direct determination of paracetamol in pharmaceutical formulations was demonstrated.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Pejić N,Kolar-Anić L,Anić S,Stanisavljev Ddoi
10.1016/j.jpba.2005.11.043subject
Has Abstractpub_date
2006-05-03 00:00:00pages
610-5issue
2eissn
0731-7085issn
1873-264Xpii
S0731-7085(05)00758-2journal_volume
41pub_type
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