Abstract：
:A simple and sensitive method is proposed for the determination of boldine by first-derivative synchronous spectrofluorimetry based on its native fluorescence in 0.1 N sulphuric acid. The constant wavelength difference (delta lambda = lambda em--lambda ex) chosen to optimize the determination is 90 nm. The linear concentration range of application is between 2.0 and 50.0 micrograms l-1 of boldine, the detection limit 0.4 microgram l-1 and the relative standard deviation at a concentration of 25 microgram l-1 was 2.1%. The method has been satisfactorily applied to the determination of boldine in pharmaceutical formulations.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Vilchez JL,Sánchez-Palencia G,Avidad R,Navalón Adoi
10.1016/0731-7085(94)90005-1subject
Has Abstractpub_date
1994-03-01 00:00:00pages
313-7issue
3eissn
0731-7085issn
1873-264Xpii
0731-7085(94)90005-1journal_volume
12pub_type
杂志文章abstract：:The pathophysiological mechanism of depression is complex and its etiology remains unclear. Metabolomics can be used to monitor multiple metabolic pathways simultaneously, thereby investigating the mechanisms of depression onset and its regulation. Therefore, we studied the metabolic profile of urine samples from a ra...
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journal_title：Journal of pharmaceutical and biomedical analysis
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