Abstract：
:The hydroxide-catalyzed non-enzymatic hydrolysis of cocaine is quantified in terms of ten site- and species-specific rate constants in connection with also ten site- and species-specific acid-base equilibrium constants, comprising all the twelve coexisting species in solution. This characterization involves the major and minor decomposition pathways via benzoylecgonine and ecgonine methyl ester, respectively, leading to ecgonine, the final product. Hydrolysis has been found to be 10-330 times faster at site 2 than at site 3, depending on the ionization status of the amino moiety and the rest of the molecule. Nitrogen protonation accelerates the hydrolyses approximately ten times both at site 2 and site 3.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Szöcs L,Völgyi G,Urai Á,Hosztafi S,Tóth G,Gergó L,Noszál Bdoi
10.1016/j.jpba.2017.07.005subject
Has Abstractpub_date
2017-10-25 00:00:00pages
372-378eissn
0731-7085issn
1873-264Xpii
S0731-7085(17)30849-Xjournal_volume
145pub_type
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