Abstract：
:This paper presents a facile and selective method for the determination of the pharmaceutical compound nafronyl using heavy atom induced room temperature phosphorimetry (HAI-RTP) as analytical technique. The determination was performed in potassium iodide 1.6 M and sodium sulphite 0.002 M at a measurement temperature of 20 degrees C. The phosphorescence intensity was then measured at lambda(exc) = 292 nm and lambda(em) = 524 nm. Phosphorescence was fully developed instantly, obtaining a linear concentration range between 2.7 and 250 ng ml(-1) with the detection limit of 2.7 ng ml(-1), an analytical sensitivity of 5.1 ng ml(-1) and a standard deviation of 2.17%, at a 150 ng ml (-1) concentration level. The proposed method has been satisfactorily applied to the unique Spanish commercial formulation containing nafronyl at a 100 mg level per capsule. The recovery was 108%, with a 1.7%, standard deviation of the analytical measurement. The method has been validated using standard addition methodology.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Cruces-Blanco C,Seguro Carretero A,Fernández Sánchez JF,Fernández Gutiérrez Adoi
10.1016/s0731-7085(00)00391-5subject
Has Abstractpub_date
2000-10-01 00:00:00pages
845-50issue
5eissn
0731-7085issn
1873-264Xpii
S0731708500003915journal_volume
23pub_type
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