Abstract：
:Schistosomiasis caused by different species of schistosome parasites is one of the most debilitating helminthic diseases of humans worldwide. For decades, chemotherapy is the main method of controlling schistosomiasis. However, the fear of drug resistance has motivated the search for alternatives. It has been demonstrated that the ABL kinase inhibitor imatinib affected the development and survival of Schistosoma mansoni in vitro; however, there is still lack of information on whether imatinib also affects other schistosome species such as Schistosoma japonicum. In the present study, the anti-schistosomal potency of imatinib on adult S. japonicum was investigated in vitro, and the results showed that imatinib had a significant impact on various physiological processes of S. japonicum adult worms. Besides its negative effects on worm motility, pairing stability, and gonad development, imatinib caused pathological changes in the gastrodermis as well as the death of the parasite. Our findings suggest that imatinib is an intriguing candidate for further development as an option to fight S. japonicum.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Li X,Haeberlein S,Zhao L,Mughal MN,Zhu T,Liu L,Fang R,Zhou Y,Zhao J,Grevelding CG,Hu Mdoi
10.1007/s00436-019-06224-xsubject
Has Abstractpub_date
2019-03-01 00:00:00pages
881-890issue
3eissn
0932-0113issn
1432-1955pii
10.1007/s00436-019-06224-xjournal_volume
118pub_type
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